DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Map3k12 and wnd

DIOPT Version :9

Sequence 1:	NP_037187.1	Gene:	Map3k12 / 25579	RGDID:	3988	Length:	888	Species:	Rattus norvegicus
Sequence 2:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	351/928 - (37%)
Similarity:	455/928 - (49%)	Gaps:	221/928 - (23%)

- Green bases have known domain annotations that are detailed below.

  Rat    78 NSVLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTE 142
            |:..|......||.|.|.|.|:...                |::.||.||::||.:.|||....|
  Fly    97 NTCQQRWPPHVGGAGAAFGHPDKPI----------------GWMYGLLGCMKPVLSFIGKTGVIE 145

  Rat   143 HKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNII 207
            .|.|:.:.|::|||.|.:|:|:|||||||||.||...|.||||||::||||||||||||.|.|||
  Fly   146 VKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHLRKLDHENII 210

  Rat   208 TFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKS 272
            .|||||||:|.:||:||||..|.|..:|:..:.:.||.||.||..||.||.|||.||||||||||
  Fly   211 KFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKS 275

  Rat   273 PNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 337
            ||:||:.::||||||||||:|.::.||||||||||||||||||||||.||||||||:||||||:|
  Fly   276 PNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEML 340

  Rat   338 TGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSFRQILLHLDIASA 402
            |.|||||||||||||||||:|||.|.|||:||:|||:|::.||..||||||||||||.|||||..
  Fly   341 TCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGP 405

  Rat   403 DVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLE 467
            ::|...::.||::|..|:|||:.|.::|...||.:|:.|::|:.||..|.|||.|||..||.||:
  Fly   406 ELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDIRMVYEDKLQ 470

  Rat   468 RANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHTSRSLLHGNTMEKLIKKRN----V 528
            :.|.|:.||:..|.||:.||:|:..|    ||:.||   |....:...|||:.|:...|.    .
  Fly   471 KTNQLFFELSECMSQLQEKEKEIAER----ERKLPG---SGYKPNRRFGNTIRKMQHYRRRLNPA 528

  Rat   529 PQKLSPHSKRPDILKT-ES-----LLPKLDA------------ALSGVGLP-------------- 561
            |..:...|..||...| ||     |..:||:            ..||:|.|
  Fly   529 PAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLANIIPSSGLGAPMPNKNKKVFRHRRN 593

  Rat   562 --GCPKAPP--SPGRSRR--GKTRHRKA---------------------SAKGSCG---DLPGLR 596
              |...|||  ||.|.||  .:..:||.                     ||:....   |:|
  Fly   594 ASGSFGAPPKYSPTRDRRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPRSQPIDVP--- 655

  Rat   597 AALPPH--------------------EPGGLGSPGGLGVGPTAWDASPPALRGLHHDLLLRKMSS 641
              :|.|                    ..|...|..| .|.|    |.|.....|....|..:.:.
  Fly   656 --VPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAG-AVNP----ACPSNGNSLSTSELTYQDAC 713

  Rat   642 SSPDLL-------------------SAALGARGR------------------------GATGGA- 662
            ||||.|                   :..|...||                        ...|||
  Fly   714 SSPDQLIDDVMNSNERLDMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNGGAS 778

  Rat   663 ----RDPGSPP--------------PPQGDTP--PSEGSAPG-STSPDSPGGAKGEPPPPVGPGE 706
                |:.|:.|              .|.||.|  .|.|:|.| |...||....:||   ......
  Fly   779 PLELRESGNSPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWSDEEGE---TTDYKY 840

  Rat   707 GVGLLGTGREGTTGRGGSRAGYQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRW 771
            .:.....||:........|..|:    |.|..:.|:   .||.:....:|.|..||....||.:.
  Fly   841 ALRRRSIGRQPIARGMRPRRSYK----APLSQKIAI---HKRNVVIVSDEEENTSEYSHSPSSQH 898

  Rat   772 ------PQGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSE 830
                  ....:|:::.:|.:|.|       :.|||.     :..|.::||....|..:..::|..
  Fly   899 STLESNTDIADMKKTQATSTSSN-------SYSEPE-----DDSSDSSDEEQGNRPTEAKAEGPA 951

  Rat   831 IP---------LDLPTSE 839
            :|         :.:||.|
  Fly   952 LPMGAVRSSDIISIPTFE 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Map3k12	NP_037187.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..104		8/25 (32%)
		STKc_MAP3K12_13	164..400	CDD:270961	174/235 (74%)
		TyrKc	165..397	CDD:197581	171/231 (74%)
		Leucine-zipper 1	423..444		7/20 (35%)
		Leucine-zipper 2	476..497		8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..620		25/126 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..731		25/122 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	743..888		24/112 (21%)
wnd	NP_649137.3	STYKc	161..400	CDD:214568	174/238 (73%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	174/235 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344416
Domainoid	1	1.000	356	1.000	Domainoid score	I952
eggNOG	1	0.900	-	-		E1_KOG4721
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1295
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003049
OrthoInspector	1	1.000	-	-		otm44868
orthoMCL	1	0.900	-	-		OOG6_105153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.650