DRSC/TRiP Functional Genomics Resources

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Protein Alignment Slc6a4 and List

DIOPT Version :10

Sequence 1:NP_037166.2 Gene:Slc6a4 / 25553 RGDID:3714 Length:630 Species:Rattus norvegicus
Sequence 2:NP_611364.2 Gene:List / 37157 FlyBaseID:FBgn0034381 Length:564 Species:Drosophila melanogaster


Alignment Length:548 Identity:196/548 - (35%)
Similarity:306/548 - (55%) Gaps:30/548 - (5%)


- Green bases have known domain annotations that are detailed below.


  Rat    80 ETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHR 144
            |.||..::||.|.|..:|.||||||||||.:|||||.|::||.|..:..|.|::|:|::|||:..
  Fly    19 EQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTG 83

  Rat   145 NGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNC 209
            .|.:..: .:.|:.||:.....:......:||::|:|..|.:.::|....|||:.|..||.| :|
  Fly    84 RGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGT-DC 146

  Rat   210 TNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQD-LGTISWQLTLCIVLIFTVIYFSIWKG 273
            .:..||:    :....|||:.::.|.:|  |:...:.: |...:|||..|:.:.:.||...:.:|
  Fly   147 HDGNAQN----SSGKMSPAQLYFEREIL--HEVPNIDNGLSLPNWQLVACLAIAWLVIGGVLIRG 205

  Rat   274 VKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLG 338
            :|:|||..:....|||:||.:||:|..|||||..|::::.||.|::||...||..|..|:||||.
  Fly   206 IKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLA 270

  Rat   339 PGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAG 402
            ..||.|:.:||||.||.|.|.|.::.:.::..:|.::|.:.|.:||.:| |..|.|:..|.| .|
  Fly   271 ICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVK-GG 334

  Rat   403 PSLLFITYAEAIANMP-ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEF----PHIWAKRR 462
            ..|.||:|.||||... ....||::|||||..||:.||......::..:.|:|    |.||.   
  Fly   335 AGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWK--- 396

  Rat   463 EWFVLIVVITCVLG---SLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSD 524
                |...:| |||   |::.:|.||.:::.|::.|......|.:|:.|.|||:|.||:.:||.|
  Fly   397 ----LASGLT-VLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCED 456

  Rat   525 VKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICI 589
            :|.|:|...||:||:||..|:|..:..::...|:....|......||..:.|.|..:....:|.:
  Fly   457 IKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQL 521

  Rat   590 P---TYIIYRLISTPGTLKERIIKSITP 614
            |   .|.||:.....|:..:||..:..|
  Fly   522 PGWAIYAIYKKRGHNGSFWQRIRAACKP 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Slc6a4NP_037166.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 23..60
5HT_transport_N 24..64 CDD:397524
SLC6sbd_SERT 79..615 CDD:271399 196/548 (36%)
Interaction with RAB4A. /evidence=ECO:0000250 616..624
ListNP_611364.2 SLC6sbd 19..489 CDD:271359 181/486 (37%)
Blue background indicates that the domain is not in the aligned region.

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