Protein Alignment Slc6a4 and CG15279

DIOPT Version :10

• Sequence 1: NP_037166.2
• Gene: Slc6a4 / 25553
• RGDID: 3714
• Length: 630
• Species: Rattus norvegicus
• Sequence 2: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 212/641 - (33%)
• Similarity: 348/641 - (54%)
• Gaps: 68/641 - (10%)

  Rat     1 METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPA 65
            |:||..|.|.:.....|..             :||...|   ||....|:...|...||: .:|.
  Fly     1 MDTTQRNHQNLAFVGDDGR-------------STASTVE---ISTNSPALRDNSDDQEAA-KVPE 48

  Rat    66 ATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGI 130
                        ||.||||.::||:|.|..:|.|||:||||:....|||||||:||.|:....|.
  Fly    49 ------------ERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGK 101

  Rat   131 PLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRL 195
            |::|:|:.:||:...|.:.:: .:||..||:|.......|.:::||..::|....|.|.|..:.|
  Fly   102 PIYYLEMVIGQFSSRGSVKVF-DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPL 165

  Rat   196 PWTSCTNSWNTGNCTNYFAQDNITW-------------TLHS-----TSPAEEFYLRHVLQIHQS 242
            ||::|...|.. :|.| .|.|...|             |:.|     .:.:|.::::.||  |:.
  Fly   166 PWSTCRAEWGI-HCIN-SAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFVKEVL--HEK 226

  Rat   243 KGLQD-LGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAW 306
            ..::: :|..:|:|.:.:.:.::.::|.|.:|||:|||..:..|.|||:::.|||||..||||:.
  Fly   227 PNIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSI 291

  Rat   307 RGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMT 371
            .|:.:::||.|.|:|:..||..|..|.|:||...||.::.::|:|||.:|.::||.:.:.::.||
  Fly   292 DGIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMT 356

  Rat   372 SFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAGPSLLFITYAEAIA---NMPASTFFAIIFFLMLI 432
            |.::||.||.:||::| |:..:|:..|.| .|..|.||:|.:|||   |:|  ..|:::|||||.
  Fly   357 SLLAGFTIFGILGHLAHEIGTDDIGSVVK-GGAGLAFISYPDAIAKFKNLP--QIFSVLFFLMLF 418

  Rat   433 TLGLDSTFAGLEGVITAVLDEFPHI--WAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEY 495
            .||:.|..|.....:||:.|.||:.  |    :..:||.|::..:| |:.:|.||.|::||::.:
  Fly   419 VLGIGSNIAMTSCSVTAIRDRFPNFGQW----QCSLLIAVVSFFIG-LMYITPGGQYMLTLVDFF 478

  Rat   496 ATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSP 560
            ......|.:.:.|...:.|.||..:.|.|::.|||...|.:||:||..|:||.:..|:..|..:.
  Fly   479 GASMIALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATY 543

  Rat   561 PQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPG-TLKERIIKSITPE 615
            ..|......||:||..:|:.|....::.:|.::|..::..|| ||..:|..:.||:
  Fly   544 QPLTYNNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPK 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..60		8/36 (22%)
		5HT_transport_N	24..64	CDD:397524	9/39 (23%)
		SLC6sbd_SERT	79..615	CDD:271399	194/561 (35%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		212/641 (33%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:444915	193/560 (34%)