DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc5a1 and CG31668

DIOPT Version :9

Sequence 1:	NP_037165.1	Gene:	Slc5a1 / 25552	RGDID:	3713	Length:	665	Species:	Rattus norvegicus
Sequence 2:	NP_001097055.2	Gene:	CG31668 / 33395	FlyBaseID:	FBgn0051668	Length:	590	Species:	Drosophila melanogaster

Alignment Length:	649	Identity:	140/649 - (21%)
Similarity:	248/649 - (38%)	Gaps:	162/649 - (24%)

- Green bases have known domain annotations that are detailed below.

  Rat    28 DISVIVIYFVVVMAVGLWAMF------------STNRG-----------TVGGFFLAGRSMVWWP 69
            |.:|.:...::.:|:||:..|            .||..           .:..:.:..|::..:|
  Fly    10 DYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMMGSRNLRVFP 74

  Rat    70 IGASLFASNIGSGHFVGLAGTGAAAGIAMGGFEWNALVFVVVL-----GWLFVPIYIKAGVVTMP 129
            :|.||.||.|.:   |.:.||  .:.|...|.::..:|..:||     .::::|::....|.:..
  Fly    75 VGMSLIASCISA---VAIIGT--PSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQVTSSY 134

  Rat   130 EYLRKRFGG--KRIQIYLSVLSLLLYI-FTKISADIFSGAIFINLALGLDIYLAIFILLAITALY 191
            |||..||..  :.|...:.:|.::||: |.     .:..|:.:|...|:::||....::.|..:|
  Fly   135 EYLEMRFHSAIRSIVSIIFILDVVLYLPFL-----AYLPALALNQVSGMNMYLIEAFIIVICVIY 194

  Rat   192 TITGGLAAVIYTDTLQTAIMLVGSFILTGFAFREVGGYEAFMDKYMKAIPTLVSDGNITVKEECY 256
            |:.|||.||::||..|..||......:...|       ..::|.....:..||..|.:...|...
  Fly   195 TVLGGLKAVVHTDIWQVVIMFASVLTIVVLA-------TCYIDDQADFLEGLVRGGRLIFSETNP 252

  Rat   257 TPRADSFHIFRDPITGDMPWPGLIFGLSILALWYW----CTDQVIVQRCLSAKNMSHVKAGCTLC 317
            :|.|.  |.....:.|:              .:||    ...|.:|.|.:|...:...:|...
  Fly   253 SPFAR--HTVWSVVIGN--------------TFYWTSLNAVHQTVVHRYMSLPTLKMARASIA-- 299

  Rat   318 GYLKLLPMFLMVMPG-MISRILYTDKIACVLPSECKKYCGTPVGCTNIAYPTLVVELMPN--GLR 379
                    ||:|... .||.:.|...:......:|.......:...:...|..||..:.:  |:.
  Fly   300 --------FLVVGAAFFISLLCYLGLLIFHAYRDCDPLSAGLIMNDDQLVPLFVVNSLGHVYGMP 356

  Rat   380 GLMLSVMMASLMSSLTSIFNSASTLFTMDIYT---KIRKGASEKELMIAGRLFILVLIGISIAWV 441
            ||.::.:..:.:|||:...||.|.:...|:..   |:..|.....:::.|.:.:|.|:..::.:
  Fly   357 GLFIAGIFGASLSSLSVYLNSTSLVILQDLVRGCFKMELGEWASTIVVKGSIVVLGLLAFAMVF- 420

  Rat   442 PIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLILGFLIG--ISRMIT-- 502
              |....||.|     ||:..|. .|||.....||...:..|   |...:|..:|  .|.::|
  Fly   421 --VLEKVSGVL-----SISVSLA-AIAASSTFGIFTVGMLVP---WANTVGTAVGGIASVLLTGW 474

  Rat   503 -----EFAYGTG------------SCM------------EPSNCPKIICGVHYLYFAIILFAISV 538
                 :||..:|            .|:            |....|......|:      :..|.|
  Fly   475 ISFGSQFAAASGQLGSQRLPVSVEGCLANASVAENAWVAEEEVFPLYRLSYHW------ISPIGV 533

  Rat   539 VTVLV----ISLLTKP-----------IPDVH--LYRLCWSLRNSTEERIDLDAGEEEPVEEDP 585
            :||:|    :||:|||           .|.:|  |.:.|:...|:          ||..|:::|
  Fly   534 LTVVVVGSLVSLVTKPTDIKSLDSDLITPVIHRFLPKECFEQGNA----------EENSVKDNP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a1	NP_037165.1	SLC5-6-like_sbd	27..665	CDD:382020	140/649 (22%)
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	121/581 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340236
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750