DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc1a1 and Eaat2

DIOPT Version :9

Sequence 1:	XP_038957786.1	Gene:	Slc1a1 / 25550	RGDID:	3696	Length:	527	Species:	Rattus norvegicus
Sequence 2:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	224/510 - (43%)
Similarity:	326/510 - (63%)	Gaps:	45/510 - (8%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MGKPTS-------SGCD--------WRRFLRNHWLLLSTVAAVVLGESRAIVVGVLVRG---HSE 47
            ||.|||       :.|.        :||:|..:.:||.|::.|:||    :::|:.:|.   |.:
  Fly    17 MGPPTSTELPPKTTECSDAPVELTGYRRWLSENLMLLVTLSGVLLG----VILGLSLRPLNLHGD 77

  Rat    48 LSNLDKFYFAFPGEILMRMLKLVILPLIISSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVIL 112
            ...|    .::|||:.||:|||:||||:|||:|.|.|:|::.::|||.||.:||:.||:.....|
  Fly    78 SIML----ISYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAAL 138

  Rat   113 GIVLVVSIKPGVTQKVNEINRTGKTPEVSTVDAMLDLIRNMFPENLVQACFQQYKT---KREEVK 174
            ||.||:.|.||.....|..:|:.....|:.:|::|||.||:||:||.||..||..|   .:..:.
  Fly   139 GIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSIL 203

  Rat   175 PASDPGGNQTEVSVTTAMTTMSENKTKEYKIVG--LYSDGINVLGLIIFCLVFGLVIGKMGEKGQ 237
            ...:...|.|..|.:.|. .:||:.|::..:|.  .|..|.|.||::.||||||..:|.:|:|||
  Fly   204 HVFNETMNDTLASGSEAQ-RLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQ 267

  Rat   238 ILVDFFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMA-------TVLSG 295
            ::||||.|:.:..||:|..:|...|:||..:|||||:.|.|      |||.|:       ||..|
  Fly   268 VVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGD------LGLVMSQLMWFIVTVAIG 326

  Rat   296 LAIHSLVVLPLIYFIVVRKNPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRF 360
            :.|:..||:..|||:|||:|||:|..|:.||:|||...:|::|.||:||||..||..||.|||||
  Fly   327 VFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRF 391

  Rat   361 VLPVGATINMDGTALYEAVAAVFIAQLNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIV 425
            |||:|..|||||||||.|||::||||::||.|..|:::|:.:|:||||:.:|.||.|.||.:::|
  Fly   392 VLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVV 456

  Rat   426 LSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQVDVSS 480
            |:|:..|.:||||:.||||.:||.||..|:|||.:...:||:||:|||..:|.:|
  Fly   457 LTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRKELMALDAAS 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc1a1	XP_038957786.1	SDF	20..468	CDD:395299	208/462 (45%)
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	206/459 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm44906
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.730