Protein Alignment Slc1a1 and Eaat2

DIOPT Version :10

• Sequence 1: NP_037164.3
• Gene: Slc1a1 / 25550
• RGDID: 3696
• Length: 523
• Species: Rattus norvegicus
• Sequence 2: NP_001162844.1
• Gene: Eaat2 / 33247
• FlyBaseID: FBgn0026438
• Length: 579
• Species: Drosophila melanogaster
• Alignment Length: 506
• Identity: 224/506 - (44%)
• Similarity: 326/506 - (64%)
• Gaps: 41/506 - (8%)

  Rat     1 MGKPTS-------SGCD--------WRRFLRNHWLLLSTVAAVVLGIVVGVLVRG---HSELSNL 47
            ||.|||       :.|.        :||:|..:.:||.|::.|:||:::|:.:|.   |.:...|
  Fly    17 MGPPTSTELPPKTTECSDAPVELTGYRRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIML 81

  Rat    48 DKFYFAFPGEILMRMLKLVILPLIISSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVL 112
                .::|||:.||:|||:||||:|||:|.|.|:|::.::|||.||.:||:.||:.....|||.|
  Fly    82 ----ISYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIAL 142

  Rat   113 VVSIKPGVTQKVNEINRTGKTPEVSTVDAMLDLIRNMFPENLVQACFQQYKT---KREEVKPASD 174
            |:.|.||.....|..:|:.....|:.:|::|||.||:||:||.||..||..|   .:..:....:
  Fly   143 VLLIHPGNPDLHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFN 207

  Rat   175 PGGNQTEVSVTTAMTTMSENKTKEYKIVG--LYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVD 237
            ...|.|..|.:.|. .:||:.|::..:|.  .|..|.|.||::.||||||..:|.:|:|||::||
  Fly   208 ETMNDTLASGSEAQ-RLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVD 271

  Rat   238 FFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMA-------TVLSGLAIH 295
            ||.|:.:..||:|..:|...|:||..:|||||:.|.|      |||.|:       ||..|:.|:
  Fly   272 FFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGD------LGLVMSQLMWFIVTVAIGVFIY 330

  Rat   296 SLVVLPLIYFIVVRKNPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPV 360
            ..||:..|||:|||:|||:|..|:.||:|||...:|::|.||:||||..||..||.||||||||:
  Fly   331 QFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPI 395

  Rat   361 GATINMDGTALYEAVAAVFIAQLNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIVLSAV 425
            |..|||||||||.|||::||||::||.|..|:::|:.:|:||||:.:|.||.|.||.:::||:|:
  Fly   396 GCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAI 460

  Rat   426 GLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQVDVSS 476
            ..|.:||||:.||||.:||.||..|:|||.:...:||:||:|||..:|.:|
  Fly   461 DAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRKELMALDAAS 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc1a1	NP_037164.3	GltP	51..467	CDD:440912	200/427 (47%)
Eaat2	NP_001162844.1	SDF	51..499	CDD:425646	208/458 (45%)