Protein Alignment GABRA2 and GluClalpha

DIOPT Version :9

• Sequence 1: NP_001317619.1
• Gene: GABRA2 / 2555
• HGNCID: 4076
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Alignment Length: 510
• Identity: 176/510 - (34%)
• Similarity: 258/510 - (50%)
• Gaps: 83/510 - (16%)

Human    20 WDPARLVLANIQEDEAKNNITIFTR-----ILDRLLDG--YDNRLRP-GLG--DSITEVFTNIYV 74
            |  |.|..|::......||..|..|     :||::|..  ||.|:|| |:.  |....|..||:|
  Fly     8 W--AILYFASLCSASLANNAKINFREKEKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFV 70

Human    75 TSFGPVSDTDMEYTIDVFFRQKWKDERLKF---KGPMNILRLNNLMASKIWTPDTFFHNGKKSVA 136
            .|...:.|..|||::.:.||::|.||||||   :|.:..|.|..  |:::|.||.||.|.|:...
  Fly    71 RSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHF 133

Human   137 HNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYN 201
            ||:.|||..:||..:|::||::|:::...|||:|:.:|:|...|.|:..||.:||:::.::|  .
  Fly   134 HNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLW--K 196

Human   202 ASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVI 266
            ..|.|||..: ..|.::.|..........|::||||:.:......||:..|::||.|:||.|.||
  Fly   197 EGDPVQVVKN-LHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVI 260

Human   267 LSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEF 331
            :|.|||||::.:||||...||||:|||.|.:.....|||.|:|..|:|.:..||..|||.||:||
  Fly   261 VSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEF 325

Human   332 ATVNYFTKRGWAWDGKSVVNDKSPSIKAEGITLTYNSVKAILQGAKLIWSKYIAFSWPSLF---- 392
            |.|||.::     .|.:..|....::|.:...|...|:.|  ....|.......|:..|.|
  Fly   326 ALVNYASR-----SGSNKANMHKENMKKKRRDLEQASLDA--ASDLLDTDSNATFAMASQFARGG 383

Human   393 -QEKTLE-------YLEKWMDCLTFKQSSKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISK 449
             |:|.|.       .|||.:.|....|:.|:                    ||..|    :.:||
  Fly   384 GQQKPLVRHPGDPLALEKRLQCEVHMQAPKR--------------------PNCCK----TWLSK 424

Human   450 SATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNRE 504
            .             |..:|       :||.:|||.||::|..||||||:|||.||
  Fly   425 F-------------PTRSK-------RIDVISRITFPLVFALFNLVYWSTYLFRE 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	169/499 (34%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	74/209 (35%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	171/504 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910