Protein Alignment GABRA2 and Rdl

DIOPT Version :9

• Sequence 1: NP_001317619.1
• Gene: GABRA2 / 2555
• HGNCID: 4076
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 163/583 - (27%)
• Similarity: 242/583 - (41%)
• Gaps: 166/583 - (28%)

Human    45 ILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKF-KGP- 107
            |||.....||.|:||..|....||...:||.|...:|:..|::|:|.:|||.|.|.||.: |.|
  Fly    62 ILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG 126

Human   108 MNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLED 172
            :..|.:.:.....||.|||||.|.|:|..|..|..|:.:|:...|::..::|||:.|.|||:|:.
  Fly   127 VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQY 191

Human   173 FPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEY 237
            ||||...|.::..|:.||..::.|.|....| ||.::.: ..|.|:.:||.......|..:||.|
  Fly   192 FPMDRQLCHIEIESFGYTMRDIRYFWRDGLS-SVGMSSE-VELPQFRVLGHRQRATEINLTTGNY 254

Human   238 TVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARN 302
            :.:.......|.:||::||.|:|..:.||:|.|||||||.:.|||...|||||||||||..|...
  Fly   255 SRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNA 319

Human   303 SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKSPSIKAEGITLTYN 367
            :|||::|..::|.::..|:..||::|:|:|||.|..||
  Fly   320 ALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKR--------------------------- 357

Human   368 SVKAILQGAKLIWSKYIAFSWPSLFQEKTLEYLEKWMDCLTFKQSSKKEKASV------------ 420
                 :|..|   .:::|.       :|..|..::.:|....:|::....|:|
  Fly   358 -----IQMRK---QRFMAI-------QKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGG 407

Human   421 ---------------------------------------MIQNNAYAVAVANYAPNLSK------ 440
                                                   .:.|.  .:..:|...|:..
  Fly   408 PGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNR--PIGFSNIQQNVGTRGCSIV 470

Human   441 DPVLSTI----------SKSAT-------------------------------------TPEPNK 458
            .|:...:          ||..|                                     .||...
  Fly   471 GPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGG 535

Human   459 KPEN-------KPAEAKKT--FNSV-----SKIDRMSRIVFPVLFGTFNLVYWATYLNREPVL 507
            .||.       .|.:.||.  .|.:     |.||:.|||||||.|..|||:||..||:...|:
  Fly   536 DPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSDVV 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	160/574 (28%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	70/203 (34%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	63/184 (34%)
		Neur_chan_memb	274..588	CDD:397193	81/357 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010