Protein Alignment GABRA1 and GluClalpha

DIOPT Version :10

• Sequence 1: NP_000797.2
• Gene: GABRA1 / 2554
• HGNCID: 4075
• Length: 456
• Species: Homo sapiens
• Sequence 2: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 169/487 - (34%)
• Similarity: 250/487 - (51%)
• Gaps: 71/487 - (14%)

Human     6 GLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTR-----ILDRLLDG--YDNRLRPGLGE 63
            |.....|| ||..::|...|         |.:|..:..|     :||::|..  ||.|:||. |.
  Fly     2 GSGHYFWA-ILYFASLCSAS---------LANNAKINFREKEKKVLDQILGAGKYDARIRPS-GI 55

Human    64 RVTE----VKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKF---KGPMTVLRLNNLMASKI 121
            ..|:    |:.:|||.|...:.|..|||::.:.||:.|.||||||   :|.:..|.|..  |:::
  Fly    56 NGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTE--ANRV 118

Human   122 WTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGS 186
            |.||.||.|.|:...||:.|||..:||..:|::||::|:::...|||:|:.:|:|...|.|:..|
  Fly   119 WMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMAS 183

Human   187 YAYTRAEVVYEWTR-EPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
            |.:|..::|:.|.. :|.:.|    ....|.::.|.....|....:::||||..:......||:.
  Fly   184 YGWTTNDLVFLWKEGDPVQVV----KNLHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREF 244

Human   251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDW 315
            .|::||.|:||.|.||:|.|||||::.:||||...||||:|||.|.:.....|||.|:|..|:|.
  Fly   245 SYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDV 309

Human   316 FIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLA 380
            :..||..|||.||:|||.|||.::.|         ..|....|:.:.||.......:.....:|.
  Fly   310 WTGVCLTFVFGALLEFALVNYASRSG---------SNKANMHKENMKKKRRDLEQASLDAASDLL 365

Human   381 RGDPGLATIAKSATI---------------EP----KEVKPETKPPEPK-----KTFNS-----V 416
            ..|.. ||.|.::..               :|    |.::.|.....||     ||:.|     .
  Fly   366 DTDSN-ATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRS 429

Human   417 SKIDRLSRIAFPLLFGIFNLVYWATYLNREPQ 448
            .:||.:|||.|||:|.:||||||:|||.||.:
  Fly   430 KRIDVISRITFPLVFALFNLVYWSTYLFREEE 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA1	NP_000797.2	LIC	14..442	CDD:455710	161/471 (34%)
		LGIC_ECD_GABAAR_A1	56..249	CDD:349835	68/200 (34%)
		Cys-loop	166..180	CDD:349835	6/13 (46%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	163/478 (34%)