Protein Alignment GABRA1 and HisCl1

DIOPT Version :10

• Sequence 1: NP_000797.2
• Gene: GABRA1 / 2554
• HGNCID: 4075
• Length: 456
• Species: Homo sapiens
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 404
• Identity: 126/404 - (31%)
• Similarity: 195/404 - (48%)
• Gaps: 57/404 - (14%)

Human    53 YDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMT----VLRL 113
            ||....|.|..:.|.|...:.|.|...:::..|.|..|:|..|||:|.||:....|:    :|.:
  Fly    67 YDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIFLAQSWRDPRLRLPENMSEQYRILDV 131

Human   114 NNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAH 178
            :.|  ..||.||.||.|.||...|.|::||..|.:..|.||||..:||:...|.|..|.:|.|..
  Fly   132 DWL--HSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQ 194

Human   179 ACPLKFGSYAYTRAEVVYEWT-REPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTT 242
            .|.:...|.::|..::|:.|. .:|    :|......|.|.|:.........::.|||.:..:..
  Fly   195 ICSMMIESLSHTVEDLVFIWNMTDP----LVVNTEIELPQLDISNNYTTDCTIEYSTGNFTCLAI 255

Human   243 HFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKV 307
            .|:|:|::||.:..||:|..:.|::|.:|||:..|::|||...|||::||:.|.:..::.|||.|
  Fly   256 VFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPV 320

Human   308 AYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTA 372
            :|..|:|.:::.|..|||.:|:|||.|                              ||...|.|
  Fly   321 SYVKAIDVWMSSCSVFVFLSLMEFAVV------------------------------NNFMGPVA 355

Human   373 TSYTPNLARGDPGLATI--AKSATIEPKE--VKPETKPPEPKKTF----NSVSKIDRLSRIAFPL 429
            |......:  |..::.:  .|||....:|  ::|:      ..||    .:...||:.||..||.
  Fly   356 TKAMKGYS--DENISDLDDLKSALQHHRESIIEPQ------YDTFCHGHATAIYIDKFSRFFFPF 412

Human   430 LFGIFNLVYWATYL 443
            .|.|.|:|||.|:|
  Fly   413 SFFILNIVYWTTFL 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA1	NP_000797.2	LIC	14..442	CDD:455710	124/401 (31%)
		LGIC_ECD_GABAAR_A1	56..249	CDD:349835	60/197 (30%)
		Cys-loop	166..180	CDD:349835	5/13 (38%)
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	58/189 (31%)
		Cys-loop	182..196	CDD:349793	5/13 (38%)
		LGIC_TM_anion	265..>351	CDD:349851	37/115 (32%)
		TM1 helix	265..288	CDD:349851	9/22 (41%)
		TM2 helix	292..316	CDD:349851	9/23 (39%)
		TM3 helix	324..350	CDD:349851	12/55 (22%)