Protein Alignment GABRA1 and nAChRbeta3

DIOPT Version :10

• Sequence 1: NP_000797.2
• Gene: GABRA1 / 2554
• HGNCID: 4075
• Length: 456
• Species: Homo sapiens
• Sequence 2: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Alignment Length: 474
• Identity: 101/474 - (21%)
• Similarity: 174/474 - (36%)
• Gaps: 102/474 - (21%)

Human     5 PGLSDCLWAWILLLSTLTGRSY-------GQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLG 62
            |||.       |||..|.|...       |..:..|....|.....|:...|...||:.::|...
  Fly    14 PGLP-------LLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQ 71

Human    63 ERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLN--NLMASKIWTPD 125
            ...|.|..::.|| :..:.:.:.:.|...:....|:||...:: |.....:.  .|.:|::|||.
  Fly    72 GTPTNVSLEMVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQ-PSQYDNITQITLKSSEVWTPQ 134

Human   126 TFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYT 190
            ....||.:    ...|....:.::.||...:.......|.|.:::.::|.|..:|.||.||:..
  Fly   135 ITLFNGDE----GGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSWGL- 194

Human   191 RAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVD-SGIVQSSTGEYVVMTTHFHLKRKIGYF- 253
                          .||:.|:|:      ..|:::| ..:|||...|.|....||..:...||.
  Fly   195 --------------KVVLPENGT------ARGESLDHDDLVQSPEWEIVDSRAHFVSQDYYGYME 239

Human   254 --------------VIQTYLPCIMTVILSQVSFWL----NRESVPARTVFGVTTVLTMTTLSISA 300
                          ||.|...||  |||:..:|||    ..|.:   .:.|:..::....|...|
  Fly   240 YTLTAQRRSSMYTAVIYTPASCI--VILALSAFWLPPHMGGEKI---MINGLLIIVIAAFLMYFA 299

Human   301 R------NSLPKVA--YATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKV 357
            :      |:.|.|.  |:|:: .:::|      |.::|...:...|.:     .|..:||..:|
  Fly   300 QLLPVLSNNTPLVVIFYSTSL-LYLSV------STIVEVLVLYLATGK-----HKRRLPEALRK- 351

Human   358 KDPLIKKN-------NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFN- 414
               |:..:       :.::.|..|........|......|......|..:.....|......|:
  Fly   352 ---LLHGHLGTWLLLSVFSTTGESQAEKTKEMDEHPYEEADEQESSPLGINHTEVPGAKANQFDW 413

Human   415 --SVSKIDRLSRIAFPLLF 431
              ..:.:||:|.::|.|.|
  Fly   414 ALLATAVDRISFVSFSLAF 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA1	NP_000797.2	LIC	14..442	CDD:455710	98/465 (21%)
		LGIC_ECD_GABAAR_A1	56..249	CDD:349835	42/195 (22%)
		Cys-loop	166..180	CDD:349835	3/13 (23%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	92/442 (21%)