Protein Alignment GABRA1 and Lcch3

DIOPT Version :10

• Sequence 1: NP_000797.2
• Gene: GABRA1 / 2554
• HGNCID: 4075
• Length: 456
• Species: Homo sapiens
• Sequence 2: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 479
• Identity: 170/479 - (35%)
• Similarity: 239/479 - (49%)
• Gaps: 81/479 - (16%)

Human    32 QDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQS 96
            :|.|.......|:.:..:|.|||.||||..|.....|..|:.:.||..:|:.:|:|||.::..|.
  Fly    30 KDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQY 94

Human    97 WKDERLKFK------------GPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIT 149
            |:||||.|.            |...||.|:...|.|||.|||||.|.|.|..|::|..|||:|:.
  Fly    95 WRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLG 159

Human   150 EDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSR 214
            .||.:.|.||.|....|.|.|..:|:|:..|.::..||.||.::||..|...|.|.|..||
  Fly   160 GDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAE---- 220

Human   215 LNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 279
            |.|:.::|...:....:.:||.|..::..|.|:|.|||||.|||||.|:.|:||.||||:|.|:.
  Fly   221 LPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEAT 285

Human   280 PARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAW 344
            .||...|:||||||||:|...|:|||:::|..|:|.::.:|:.|||:||:|:|.||      |.:
  Fly   286 SARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVN------YTY 344

Human   345 DGKSVVPEKPKKVKD--------------------------------PLIKKNNTYAPTATSY-- 375
            .||. ..:|.||||:                                |.::: .||..|..|.
  Fly   345 WGKR-AKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRR-GTYNATLDSIGT 407

Human   376 -TPNLARGDP----------GLATIAKSA----TIEP------KEVKPETKPPEPKKTFNSVSKI 419
             |.||.:..|          |.:.:.:.|    :..|      |......|...||  ...|:.|
  Fly   408 ETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPK--IKDVNII 470

Human   420 DRLSRIAFPLLFGIFNLVYWATYL 443
            |:.||:.||:.|..|||.||..|:
  Fly   471 DKYSRMIFPISFLAFNLGYWLFYI 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA1	NP_000797.2	LIC	14..442	CDD:455710	169/476 (36%)
		LGIC_ECD_GABAAR_A1	56..249	CDD:349835	75/204 (37%)
		Cys-loop	166..180	CDD:349835	5/13 (38%)
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	169/476 (36%)