Protein Alignment GABRA1 and CG6927

DIOPT Version :10

• Sequence 1: NP_000797.2
• Gene: GABRA1 / 2554
• HGNCID: 4075
• Length: 456
• Species: Homo sapiens
• Sequence 2: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 130/540 - (24%)
• Similarity: 212/540 - (39%)
• Gaps: 138/540 - (25%)

Human    14 WILLLSTLTGRSYGQPSLQDE----LKDNTTVF-TRILDRLLDG--YDNRLRP----GLGERVTE 67
            |.|::|.|....|...|..||    |.|..::. |::||||..|  ||...||    ..|:|
  Fly     3 WSLIISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITYSETGQR--- 64

Human    68 VKTDIFVTSF----GPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNL----MASKIWTP 124
            :..|:::.::    ..:..||:::.|....:..:.|.||.|:......|...|    :.:.:|.|
  Fly    65 LPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRNSLWMP 129

Human   125 DTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAY 189
            ..|..|.:.|....:|..:.|..|:.|||::.:.|:.....|.::|:.||.|...|.....|:.|
  Fly   130 HIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMY 194

Human   190 TRAEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIVQSS---------TGEYVVMTTHF 244
            ..:|:|..|  |..|.:..  ||: .|.::.|.....:..::.:.         .|.|..::...
  Fly   195 NTSELVLHW--EQKRPITY--DGALHLTEFVLQRSWSNETVINADLSDLRHGAFAGNYSSLSFTV 255

Human   245 HLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAY 309
            ||.|.:|::::..:||.::.|.:|.|||||..:..|.|...|.:|:||..||:.:...:||||:|
  Fly   256 HLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSY 320

Human   310 ATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTAT 373
            ....: ||:. |..|:|.:::|||.||..      |..|..||          :||.|:.....:
  Fly   321 IKVSEVWFLG-CTIFIFGSMVEFAFVNTI------WRRKKSVP----------VKKLNSKHILKS 368

Human   374 SYTPNLAR---------------------GDPGLATIAKSATIE-PKEVKPETKPPEPKKTFNSV 416
            :.:|||.|                     |..|.|......|:. |.....|.:..:.::|...|
  Fly   369 TLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVV 433

Human   417 SK--------------------------------------------------------------I 419
            .|                                                              |
  Fly   434 QKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWI 498

Human   420 DRLSRIAFPLLFGIFNLVYW 439
            |..:|..|||.|.:|||.:|
  Fly   499 DSRARFVFPLSFLVFNLFFW 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABRA1	NP_000797.2	LIC	14..442	CDD:455710	130/540 (24%)
		LGIC_ECD_GABAAR_A1	56..249	CDD:349835	47/214 (22%)
		Cys-loop	166..180	CDD:349835	5/13 (38%)
CG6927	NP_572194.1	LIC	3..520	CDD:455710	130/540 (24%)