DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phex and Nepl4

DIOPT Version :9

Sequence 1:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus
Sequence 2:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	754	Identity:	158/754 - (20%)
Similarity:	256/754 - (33%)	Gaps:	221/754 - (29%)

- Green bases have known domain annotations that are detailed below.

  Rat    66 IMSKVNLSVDPCENFFRFACDGW------------ISNNPIP---EDM----------PSYGVYP 105
            :||.|:...:|||:|:.:||..|            ||.:.|.   ||:          |.|| ||
  Fly    50 LMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYG-YP 113

  Rat   106 WLRHNVDLKLKALLEKSVSRRRDTEAVQKAKIL--YSSCMNEKAIEKADAKPLLHILRH------ 162
            ..                           ||:|  |.||:   |:||.|.:..:.:|..
  Fly   114 MF---------------------------AKVLAHYQSCI---ALEKPDLRRYIELLDRDLLASL 148

  Rat   163 SPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKL-DQAT 226
            :...|..|.|.:|..|               :.|.|. .|.:|.|     .|::..|..| ....
  Fly   149 NSTHWMHLLAALGRYG---------------YHGHYV-QVEVRWY-----NATHHMIFLLPHNRH 192

  Rat   227 LSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLR-LEIKIAEIMIPHEN 290
            |:|::.:|..|..::..|....|                   |.::...| ||..:..:..||
  Fly   193 LNLSLTQDIYDALSQDGSSWPPL-------------------HQLQEQFRSLEQNLVRLAKPH-- 236

  Rat   291 RTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILG 355
             :::..:...::.::...:|...|        |..|...|....|..:|.     ...||..|.|
  Fly   237 -SADDTFRNYSLDQIRTEVPGLHW--------DEALRTQLGRSVPGNHVF-----QVDDLDAIEG 287

  Rat   356 -AERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWD--------KCVNFIE 411
             .|...|:...|:.|...:|.             .|.:::.....|..|:        .|:..:.
  Fly   288 LVEYLNTVDTLLLNRYSLARF-------------LSHLLELPHNPLATWESGQRSRGRNCIRHMR 339

  Rat   412 SA--LP--YVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAV 472
            .:  ||  ||..:.|.:      ::...:||:  :...|..:..:....:.......:|:..:::
  Fly   340 RSVYLPMNYVYERSFYS------RRRHADELV--IHSVFQQLQSQLELRVQHNAFNLSQDLVKSL 396

  Rat   473 LAKV--------GYPEFIMNDTYVNEDLKAIKFSES-DYFGNVLQTRKYL--------AQSD--- 517
            .|||        ..|..:....|.:.|.   ::|.. |::.|.|.:..|.        :.||
  Fly   397 QAKVHQMRINVGNLPPNVTEQFYWDSDR---RWSVGRDFYENHLNSLLYYYTLVADLESSSDQEE 458

  Rat   518 -FFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHE 581
             ..|....:...|:..|......||... |.|..|...:::|||....:| :|.||.:...:|||
  Fly   459 RDIWYSFNMHTPEFPDNIDATPYFYCLG-NIIFVPYSYVKRPFFDANFWP-ALLYGDLANTLGHE 521

  Rat   582 FTHGFDNNGRKYDKNGNLDPWWSVDSEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIAD 646
            ..|.||.:...||..|||         ..|.::    :.:...|......|| .....|.|..:|
  Fly   522 IMHAFDTDLVDYDAQGNL---------RNFSDQ----LGEVELYNGAVGCLN-SSAVMLNERTSD 572

  Rat   647 NGGLREAFRAY-RKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAH 710
            ..|.|.|.:.| ..|:.  |.|            |.:|:||.:||..|.....:         .|
  Fly   573 VSGSRLAMQTYGGDWLT--RSG------------NGRLYFLQFAHFFCGDEGDQ---------YH 614

  Rat   711 SPPQFRVNGAISNFEEFQKAFNCPANSTMNRGADSCRLW 749
            .....|:|.|:....:|.:.|.|...|.|. .||.|..|
  Fly   615 DSGSQRLNYALGQVPQFAEVFRCHVGSGMT-SADQCPFW 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phex	NP_037136.2	M13	74..740	CDD:341056	150/735 (20%)
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	153/741 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	153/740 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920