Protein Alignment GABPA and pnt

DIOPT Version :9

• Sequence 1: NP_001184226.1
• Gene: GABPA / 2551
• HGNCID: 4071
• Length: 454
• Species: Homo sapiens
• Sequence 2: NP_524461.2
• Gene: pnt / 42757
• FlyBaseID: FBgn0003118
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 596
• Identity: 128/596 - (21%)
• Similarity: 181/596 - (30%)
• Gaps: 318/596 - (53%)

Human   137 LVEEAQVI----TLDGTKHITTISD----ETSEQVTR----------------WAAALEGYRKEQ 177
            |||...:.    .:.|.|.:.::||    |.|.:|..                ..|:...:.||.
  Fly   109 LVESKNIFIKEEPIHGCKDLCSLSDISDHEASLEVPTALPPLTPGTNRKVNEVLKASFASWEKEV 173

Human   178 ERLGIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTL-NISGRELCSLNQEDFFQRVP--RGEI 239
            ::..|..||.:|:.:.|::|:.|...|||:..::|... .:.||.:..|.:|.|....|  .|:|
  Fly   174 QKCNITKDPREWTEEHVIYWLNWAKNEFSLVSMNLDPFYKMKGRAMVDLGKEKFLAITPPFTGDI 238

Human   240 LWSHLELLRK---------------------YVLASQEQ---------------QMNEIVTID-- 266
            ||.||::|:|                     .|..|..|               .:|..:::|
  Fly   239 LWEHLDILQKDCEKPNEDIVHGNSFESATTASVCGSDHQVANYPNETHANSNNSSINSRLSMDYV 303

Human   267 -------------------------------------------QPV-------------QIIPAS 275
                                                       ||.             .::|.:
  Fly   304 TSAGNSDNKNFHRATPHSHNGYNTSNTHDRINNSTPPQQQQSQQPTVNGSGSASSNNNNSMLPPA 368

Human   276 VQSA----TPTTIKVINSSAK-----------------------------AAKV----------- 296
            ||.:    ..|:....|:|:.                             ||.:
  Fly   369 VQQSNNENNNTSSSNTNNSSNNNNNSGGSNNSNAGSNNNNNNNNNINFMAAAAIFQHHLKEEPGT 433

Human   297 --------------QRAP----------------------------------------RISGED- 306
                          |..|                                        .||.:|
  Fly   434 QNGNIGGYGGGSNSQNDPTDLSSYGLPAHLAAYGGGSGSGPTGGRSSGGGGDESDYHSTISAQDH 498

Human   307 ---RSSPGN--------RTGN-------------------------------------------- 316
               :||.||        .|||
  Fly   499 QSQQSSGGNGSGGASGGSTGNSNGYLDSSSEFYGSYAGRNRFHDGYPPEFTPYDAQSFQSMGPQP 563

Human   317 -------------------------------------------NGQIQLWQFLLELLTDKDARDC 338
                                                       :|.|||||||||||.||..:..
  Fly   564 TAMDQWGAAHAHQHPAAYMSTLGLDKGLLGGYTTQGGVPCFTGSGPIQLWQFLLELLLDKTCQSF 628

Human   339 ISWVGDEGEFKLNQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDL 403
            |||.||..||||..|:.||::||.|||||.||||||||.||||||.::|.|..|||:||:|||||
  Fly   629 ISWTGDGWEFKLTDPDEVARRWGIRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDL 693

Human   404 KTLIGYSAAEL 414
            :.|:|::..||
  Fly   694 QNLVGHTPEEL 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABPA	NP_001184226.1	GABP-alpha	40..119	CDD:402975
		SAM_PNT-GABP-alpha	168..254	CDD:176084	29/109 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..316		10/70 (14%)
		ETS	319..403	CDD:197710	56/83 (67%)
pnt	NP_524461.2	SAM_PNT-ETS-1,2	179..250	CDD:188879	24/70 (34%)
		ETS	609..693	CDD:197710	56/83 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243757at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820