Protein Alignment GABBR1 and Gabbr1

DIOPT Version :10

• Sequence 1: XP_005249039.1
• Gene: GABBR1 / 2550
• HGNCID: 4070
• Length: 966
• Species: Homo sapiens
• Sequence 2: XP_006255941.1
• Gene: Gabbr1 / 81657
• RGDID: 621537
• Length: 991
• Species: Rattus norvegicus
• Alignment Length: 991
• Identity: 948/991 - (95%)
• Similarity: 955/991 - (96%)
• Gaps: 31/991 - (3%)

Human     7 LLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYV 71
            :|||||.||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYV 65

Human    72 CRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRC 136
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat    66 CRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRC 130

Human   137 DPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMAL 201
            ||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 DPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMAL 195

Human   202 EDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWN 266
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 EDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWN 260

Human   267 LIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDL 331
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 LIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDL 325

Human   332 EERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWF 396
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 EERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWF 390

Human   397 LIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKR 461
            |||||||||||.|||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat   391 LIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKR 455

Human   462 HPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGV 526
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 HPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGV 520

Human   527 SGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRF 591
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 SGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRF 585

Human   592 LSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDG 656
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 LSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDG 650

Human   657 YHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 721
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   651 YHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 715

Human   722 LVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLG---------- 776
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||
  Rat   716 LVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSD 780

Human   777 ---------------------IFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVL 820
                                 ||||||||||||||||||||||||||||||||||||||||||||
  Rat   781 VQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVL 845

Human   821 CLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSST 885
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
  Rat   846 CLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSST 910

Human   886 NNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEP 950
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||.||
  Rat   911 NNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEP 975

Human   951 PDRLSCDGSRVHLLYK 966
            ||||||||||||||||
  Rat   976 PDRLSCDGSRVHLLYK 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABBR1	XP_005249039.1	Sushi	112..162	CDD:459664	47/49 (96%)
		PBP1_GABAb_receptor	176..575	CDD:380589	396/398 (99%)
		7tmC_GABA-B-R1	595..867	CDD:320418	269/302 (89%)
		TM helix 1	595..620	CDD:320418	24/24 (100%)
		TM helix 2	632..653	CDD:320418	20/20 (100%)
		TM helix 3	669..693	CDD:320418	23/23 (100%)
		TM helix 4	715..735	CDD:320418	19/19 (100%)
		TM helix 5	771..797	CDD:320418	25/56 (45%)
		TM helix 6	806..829	CDD:320418	22/22 (100%)
		TM helix 7	836..861	CDD:320418	24/24 (100%)
Gabbr1	XP_006255941.1	Sushi	106..156	CDD:459664	47/49 (96%)
		PBP1_GABAb_receptor	170..569	CDD:380589	396/398 (99%)
		7tmC_GABA-B-R1	589..892	CDD:320418	269/302 (89%)
		TM helix 1	589..614	CDD:320418	24/24 (100%)
		TM helix 2	626..647	CDD:320418	20/20 (100%)
		TM helix 3	663..687	CDD:320418	23/23 (100%)
		TM helix 4	709..729	CDD:320418	19/19 (100%)
		TM helix 5	765..822	CDD:320418	25/56 (45%)
		TM helix 6	831..854	CDD:320418	22/22 (100%)
		TM helix 7	861..886	CDD:320418	24/24 (100%)