Protein Alignment GABBR1 and gabbr1b

DIOPT Version :10

• Sequence 1: XP_005249039.1
• Gene: GABBR1 / 2550
• HGNCID: 4070
• Length: 966
• Species: Homo sapiens
• Sequence 2: XP_005170159.1
• Gene: gabbr1b / 558708
• ZFINID: ZDB-GENE-060503-5
• Length: 994
• Species: Danio rerio
• Alignment Length: 998
• Identity: 703/998 - (70%)
• Similarity: 814/998 - (81%)
• Gaps: 48/998 - (4%)

Human     6 MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEY 70
            ::||.||....|       |......:.||.||.||.:|||||||||::|::::..|||||||||
Zfish     5 LVLLFLLGSFSL-------AMASRNITAGCAIIRPPRDGGIRYRGLTQEQIRSVQVLPVDYEIEY 62

Human    71 VCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFL--TGGDLPALDGARVD 133
            :|||.|.:|||||||||.:|:|||::..|:|:..|.:.:.:||||:|.:  .|   ||::|..:.
Zfish    63 ICRGSRVIVGPKVRKCLPDGTWTDLNQRSKCLLPCPRVWTSLENGRVTVHPPG---PAVEGTILH 124

Human   134 FRCDPDFHLVGSSRSICSQ-GQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAV 197
            :.|...|.|||.:.:.|:: |:|.:|||.|..:| .::.::.:||||||||||||||||||.||.
Zfish   125 YSCLEGFILVGRNSTQCNKLGKWDSPKPVCHYDR-HYTGKKKLYIGALFPMSGGWPGGQACLPAA 188

Human   198 EMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAA 262
            :|||:.||.|.||||||||:|||:||.||||:|||.||:|||.:||||:||||||||||||||||
Zfish   189 QMALDLVNKRTDILPDYELELIHYDSMCDPGEATKLLYDLLYTEPIKIVLMPGCSSVSTLVAEAA 253

Human   263 RMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTST 327
            |||||||||||||||||||||||||||||||||||||||||:||:||.|.|||||||||||||||
Zfish   254 RMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVQLFQKWKWTKIATIQQTTEVFTST 318

Human   328 LDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKK 392
            |||||:|||||||||:.||||.:||||.|||||||||||||||||||||||||||||||:|:|||
Zfish   319 LDDLEQRVKEAGIEISVRQSFLTDPAVAVKNLKRQDARIIVGLFYETEARKVFCEVYKEKLYGKK 383

Human   393 YVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTK 457
            ||||||||||||||||.||||||||::||||||||:|||||||||...|..||:|||||:.:|..
Zfish   384 YVWFLIGWYADNWFKIKDPSINCTVEQMTEAVEGHVTTEIVMLNPETVRGASNLTSQEFLAQLMS 448

Human   458 RL-KRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSS 521
            :| .::||||||||||||||||:||||||||||.|.....|.|||||||||:.||.:||||:|:|
Zfish   449 KLGGKNPEETGGFQEAPLAYDAVWALALALNKTVGPLKAKGRRLEDFNYNNKDITAEIYRALNTS 513

Human   522 SFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVI 586
            |||||||||||||.||||||||||||||||||||||||.||.:|||...|:|||..||||||:||
Zfish   514 SFEGVSGHVVFDAQGSRMAWTLIEQLQGGSYKKIGYYDMTKGNLSWYGNDRWIGSGPPADQTVVI 578

Human   587 KTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFP 651
            :.||:||||||:||||.:.|||::.:|||:||||||:|||||||||.|||:|||||.:|||||||
Zfish   579 QKFRYLSQKLFVSVSVFAGLGILMGIVCLTFNIYNSNVRYIQNSQPYLNNMTAVGCMMALAAVFP 643

Human   652 LGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKT-LEPWKL 715
            ||:||.|:..:|||.|||.|||||||||||.||||||||||||||||||:|||:.||. ||||||
Zfish   644 LGIDGLHVRNSQFPVVCQFRLWLLGLGFSLAYGSMFTKIWWVHTVFTKKDEKKDKRKQHLEPWKL 708

Human   716 YATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYG 780
            |||||:|:.:|:|:|.|||||||||.|:|.|.||.||.|:|..|.|.|:||||.|||||||:.||
Zfish   709 YATVGVLLVIDILSLMIWQIVDPLHITVEKFTKEAPKGDVDELIEPLLQHCSSEKMNTWLGVVYG 773

Human   781 YKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLA 845
            |||||||||||||||||||||||||||||||||||||:|||:|||||||||||:|||:|||||||
Zfish   774 YKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVSVLCMITAPVTMILSSKQDASFAFASLA 838

Human   846 IVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEK 910
            |:||.|||||||||||||||||||||||:.|:|||||||||||:|||||.||:||:||:|||.||
Zfish   839 IIFSVYITLVVLFVPKMRRLITRGEWQSDQQETMKTGSSTNNNDEEKSRQLERENKELQKIIQEK 903

Human   911 EERVSELRHQLQSRQQLRSRRHP-----------PTP--------PEPSGGLP---------RGP 947
            ||||||||:||..||.||||:.|           |||        |.|...||         ..|
Zfish   904 EERVSELRNQLSERQALRSRKRPTSNQNHSSPSIPTPQNDPKSLLPPPGYPLPSSDNHSFSNSSP 968

Human   948 PEPPD----RLSCDGSRVHLLYK 966
            ...||    |.:|...|:.||||
Zfish   969 LYQPDGKINRNNCHPGRLQLLYK 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABBR1	XP_005249039.1	Sushi	112..162	CDD:459664	20/52 (38%)
		PBP1_GABAb_receptor	176..575	CDD:380589	329/399 (82%)
		7tmC_GABA-B-R1	595..867	CDD:320418	216/272 (79%)
		TM helix 1	595..620	CDD:320418	15/24 (63%)
		TM helix 2	632..653	CDD:320418	16/20 (80%)
		TM helix 3	669..693	CDD:320418	21/23 (91%)
		TM helix 4	715..735	CDD:320418	12/19 (63%)
		TM helix 5	771..797	CDD:320418	23/25 (92%)
		TM helix 6	806..829	CDD:320418	20/22 (91%)
		TM helix 7	836..861	CDD:320418	21/24 (88%)
gabbr1b	XP_005170159.1	CCP	97..154	CDD:214478	21/59 (36%)
		PBP1_GABAb_receptor	167..567	CDD:380589	329/399 (82%)
		7tmC_GABA-B-R1	587..860	CDD:320418	216/272 (79%)
		TM helix 1	587..612	CDD:320418	15/24 (63%)
		TM helix 2	624..645	CDD:320418	16/20 (80%)
		TM helix 3	661..685	CDD:320418	21/23 (91%)
		TM helix 4	708..728	CDD:320418	12/19 (63%)
		TM helix 5	764..790	CDD:320418	23/25 (92%)
		TM helix 6	799..822	CDD:320418	20/22 (91%)
		TM helix 7	829..854	CDD:320418	21/24 (88%)
		DD_cGKI	895..>923	CDD:473057	21/27 (78%)