Protein Alignment GABBR1 and Gabbr1

DIOPT Version :10

• Sequence 1: XP_005249039.1
• Gene: GABBR1 / 2550
• HGNCID: 4070
• Length: 966
• Species: Homo sapiens
• Sequence 2: NP_062312.3
• Gene: Gabbr1 / 54393
• MGIID: 1860139
• Length: 960
• Species: Mus musculus
• Alignment Length: 960
• Identity: 948/960 - (98%)
• Similarity: 955/960 - (99%)
• Gaps: 0/960 - (0%)

Human     7 LLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYV 71
            :|||||.||||||.|||||||||.|||||||||||||||||||||||||||||||||||||||||
Mouse     1 MLLLLLVPLFLRPLGAGGAQTPNVTSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYV 65

Human    72 CRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRC 136
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 CRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRC 130

Human   137 DPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMAL 201
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 DPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMAL 195

Human   202 EDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWN 266
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 EDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWN 260

Human   267 LIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDL 331
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 LIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDL 325

Human   332 EERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWF 396
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 EERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWF 390

Human   397 LIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKR 461
            |||||||||||.|||||||||:|||||||||||||||||||||||||||||||||||||||||||
Mouse   391 LIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKR 455

Human   462 HPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGV 526
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 HPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGV 520

Human   527 SGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRF 591
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 SGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRF 585

Human   592 LSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDG 656
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 LSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDG 650

Human   657 YHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 721
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 YHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGL 715

Human   722 LVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLL 786
            |||||:|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Mouse   716 LVGMDILTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLL 780

Human   787 LLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSY 851
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   781 LLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSY 845

Human   852 ITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSE 916
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   846 ITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSE 910

Human   917 LRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK 966
            ||||||||||:||||||||||:|||||||||.||||||||||||||||||
Mouse   911 LRHQLQSRQQIRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABBR1	XP_005249039.1	Sushi	112..162	CDD:459664	49/49 (100%)
		PBP1_GABAb_receptor	176..575	CDD:380589	396/398 (99%)
		7tmC_GABA-B-R1	595..867	CDD:320418	268/271 (99%)
		TM helix 1	595..620	CDD:320418	24/24 (100%)
		TM helix 2	632..653	CDD:320418	20/20 (100%)
		TM helix 3	669..693	CDD:320418	23/23 (100%)
		TM helix 4	715..735	CDD:320418	18/19 (95%)
		TM helix 5	771..797	CDD:320418	25/25 (100%)
		TM helix 6	806..829	CDD:320418	22/22 (100%)
		TM helix 7	836..861	CDD:320418	24/24 (100%)
Gabbr1	NP_062312.3	Sushi	106..156	CDD:459664	49/49 (100%)
		PBP1_GABAb_receptor	170..569	CDD:380589	396/398 (99%)
		7tmC_GABA-B-R1	589..861	CDD:320418	268/271 (99%)
		TM helix 1	589..614	CDD:320418	24/24 (100%)
		TM helix 2	626..647	CDD:320418	20/20 (100%)
		TM helix 3	663..687	CDD:320418	23/23 (100%)
		TM helix 4	709..729	CDD:320418	18/19 (95%)
		TM helix 5	765..791	CDD:320418	25/25 (100%)
		TM helix 6	800..823	CDD:320418	22/22 (100%)
		TM helix 7	830..855	CDD:320418	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..891		24/24 (100%)
		Interaction with ATF4. /evidence=ECO:0000250	887..915		27/27 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..960		48/51 (94%)