DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GABBR1 and gbb-1

DIOPT Version :10

Sequence 1:XP_005249039.1 Gene:GABBR1 / 2550 HGNCID:4070 Length:966 Species:Homo sapiens
Sequence 2:NP_741740.3 Gene:gbb-1 / 189837 WormBaseID:WBGene00021528 Length:899 Species:Caenorhabditis elegans


Alignment Length:328 Identity:68/328 - (20%)
Similarity:114/328 - (34%) Gaps:94/328 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     4 GTMTAWRGMR-PEVTLACLLLATAGCFADLNEVPQVTVQPA--------STVQKPGGTVILGCVV 59
            |.::||..:: |.:|  |..||::.....:.|.|:...|..        :.:|:....:.||..|
 Worm   180 GALSAWFRLKFPHLT--CGSLASSAVVRAVYEFPEFDQQIGESAGPECKAALQETNKLLELGLKV 242

Human    60 EPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTL 124
            ....:...:  |..||:...|.|.::.....:.|...|...:    ||..:.|............
 Worm   243 NNRAVKALF--NATELDVDADFLYLIADAEVMAIQYGNPDKL----CVPLVEAQKNRDDLVEAYA 301

Human   125 ANLQDFKLDV----------QHVIEVDEGNTAVIACHLPESHPK-------AQVRY--------S 164
            ..:::|.:.|          :|:::     |||    .|||..:       .:|.|        |
 Worm   302 KYVREFCVGVFGLSSKTYSRKHLLD-----TAV----TPESADRLWWFQVCTEVAYFQVAPANDS 357

Human   165 VKQEWLEA-----------SRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDR 218
            ::...:..           .:|.|..:.:.||..        |..:.||    |:.:.|:||.|.
 Worm   358 IRSHQINTEYHLDLCKSLFGKGVYPEVDATNLYY--------GSDRIAA----TKIIFTNGSQDP 410

Human   219 LRVRRSTAEAARIIYPPEAQTIIVT-----KGQSLILECVASGIP-PPRVTW--AKDGSSVTGYN 275
            .|      .|::....||..:.|||     .|..|      .|.| .|.|..  :|:.||....|
 Worm   411 WR------HASKQTSSPELPSYIVTCHNCGHGSDL------RGCPQSPMVIGGDSKNCSSPDAVN 463

Human   276 KTR 278
            |.|
 Worm   464 KVR 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABBR1XP_005249039.1 Sushi 112..162 CDD:459664 10/66 (15%)
PBP1_GABAb_receptor 176..575 CDD:380589 30/111 (27%)
7tmC_GABA-B-R1 595..867 CDD:320418
TM helix 1 595..620 CDD:320418
TM helix 2 632..653 CDD:320418
TM helix 3 669..693 CDD:320418
TM helix 4 715..735 CDD:320418
TM helix 5 771..797 CDD:320418
TM helix 6 806..829 CDD:320418
TM helix 7 836..861 CDD:320418
gbb-1NP_741740.3 PBP1_GABAb_receptor 25..426 CDD:380589 53/280 (19%)
7tmC_GABA-B-R1 447..770 CDD:320418 7/20 (35%)
TM helix 1 447..472 CDD:320418 7/20 (35%)
TM helix 2 484..505 CDD:320418
TM helix 3 523..547 CDD:320418
TM helix 4 616..636 CDD:320418
TM helix 5 673..699 CDD:320418
TM helix 6 708..731 CDD:320418
TM helix 7 739..764 CDD:320418
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.