Protein Alignment GABBR1 and gabbr1

DIOPT Version :10

• Sequence 1: XP_005249039.1
• Gene: GABBR1 / 2550
• HGNCID: 4070
• Length: 966
• Species: Homo sapiens
• Sequence 2: XP_012823396.1
• Gene: gabbr1 / 100135080
• XenbaseID: XB-GENE-956617
• Length: 987
• Species: Xenopus tropicalis
• Alignment Length: 997
• Identity: 768/997 - (77%)
• Similarity: 844/997 - (84%)
• Gaps: 52/997 - (5%)

Human     6 MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEY 70
            :|..|.|.|:|    |:|.:.|     .||:|||||.:|||||||||..||||:..||||||||:
 Frog     7 LLFALWLTPVF----GSGQSNT-----TGCRIIHPPRDGGIRYRGLTLTQVKAVEVLPVDYEIEF 62

Human    71 VCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTG-GDLPALDGARVDF 134
            |||||||:.|||||||..||:|||||.||||:..||:.:|.||||:..:.| |.:| ::|..|.|
 Frog    63 VCRGEREISGPKVRKCQRNGTWTDMDKPSRCLHTCSRMHLKLENGRADVRGMGRVP-MEGTSVQF 126

Human   135 RCDPDFHLVGSSRSICSQ-GQWSTPKPHCQVNRT------PHSER-RAVYIGALFPMSGGWPGGQ 191
            .|||.|.|||||.|:|:: |:|..|||.|||.|.      |.|.| ||:::||||||||||||||
 Frog   127 ACDPGFLLVGSSHSLCTKSGKWDHPKPICQVRRPDTSIRHPESSRKRALHVGALFPMSGGWPGGQ 191

Human   192 ACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVST 256
            |||||.:|||||||:||||||:|||:||||||:|||||||:|||||||||||||:||||||||||
 Frog   192 ACQPAAQMALEDVNNRRDILPEYELRLIHHDSQCDPGQATRYLYELLYNDPIKIMLMPGCSSVST 256

Human   257 LVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTT 321
            |||||||||:|||||||||||||||||||||||||||||||||||||:||:||||.|||||||||
 Frog   257 LVAEAARMWHLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVQLFKKWGWTKIATIQQTT 321

Human   322 EVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKE 386
            ||||||||||||||||||||||||||||||||:|||||||||||:||||||||||||||||||||
 Frog   322 EVFTSTLDDLEERVKEAGIEITFRQSFFSDPAIPVKNLKRQDARVIVGLFYETEARKVFCEVYKE 386

Human   387 RLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEF 451
            ||||||||||||||||||||||.||:|||||:|||:|||||:|||||||||.|||.|||||||||
 Frog   387 RLFGKKYVWFLIGWYADNWFKIPDPAINCTVEEMTQAVEGHVTTEIVMLNPENTRGISNMTSQEF 451

Human   452 VEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYR 516
            :|||.|||..:||.|||.||||||||||||||||||||:....:.|.|||||||||:.|:::|||
 Frog   452 MEKLKKRLGENPEMTGGLQEAPLAYDAIWALALALNKTAYELSKKGRRLEDFNYNNKMISEEIYR 516

Human   517 AMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPAD 581
            |||||||:||||||||||||||||||||||||||.||||||||||||:|||...|||||||||||
 Frog   517 AMNSSSFDGVSGHVVFDASGSRMAWTLIEQLQGGVYKKIGYYDSTKDNLSWYNNDKWIGGSPPAD 581

Human   582 QTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLAL 646
            .|.||.|||::|||||||||||:.|||:|..||||||||||||||||||||:||::||.||.|:|
 Frog   582 HTKVIITFRYVSQKLFISVSVLAGLGILLGFVCLSFNIYNSHVRYIQNSQPHLNDVTAAGCILSL 646

Human   647 AAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRK--- 708
            ||||||||||.||....||.|||||||||||||||.||||||||||:||.||||::|||.||
 Frog   647 AAVFPLGLDGRHIETWHFPLVCQARLWLLGLGFSLAYGSMFTKIWWIHTAFTKKDDKKERRKQSQ 711

Human   709 TLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNT 773
            ||||||||.||.||:|:||:||.||||||||.|:||.|.||||:.|:||.||||||||||.||||
 Frog   712 TLEPWKLYTTVSLLLGLDVITLGIWQIVDPLQRSIEEFTKEEPRGDLDVLILPQLEHCSSLKMNT 776

Human   774 WLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAA 838
            ||||.||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
 Frog   777 WLGIVYGSKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAS 841

Human   839 FAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENREL 903
            |||:|||||||:||||||||||||||||||||||||.|||:||||||||||||||||||:||:||
 Frog   842 FAFSSLAIVFSAYITLVVLFVPKMRRLITRGEWQSEQQDTLKTGSSTNNNEEEKSRLLERENQEL 906

Human   904 EKIIAEKEERVSELRHQLQSRQQLRSRRHPPTP----------PEPSG--------GLPRG---P 947
            .:|||||||||.||      ||||||||.|..|          |..||        |||..   .
 Frog   907 GRIIAEKEERVMEL------RQQLRSRRRPSVPARDNCSDNHFPNSSGAVSSLYQPGLPLARCLV 965

Human   948 PEPPDRL---SCDGSRVHLLYK 966
            .|..|:|   ||||||||||||
 Frog   966 AEGGDKLGRNSCDGSRVHLLYK 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABBR1	XP_005249039.1	Sushi	112..162	CDD:459664	26/51 (51%)
		PBP1_GABAb_receptor	176..575	CDD:380589	349/398 (88%)
		7tmC_GABA-B-R1	595..867	CDD:320418	228/274 (83%)
		TM helix 1	595..620	CDD:320418	19/24 (79%)
		TM helix 2	632..653	CDD:320418	14/20 (70%)
		TM helix 3	669..693	CDD:320418	22/23 (96%)
		TM helix 4	715..735	CDD:320418	13/19 (68%)
		TM helix 5	771..797	CDD:320418	23/25 (92%)
		TM helix 6	806..829	CDD:320418	22/22 (100%)
		TM helix 7	836..861	CDD:320418	21/24 (88%)
gabbr1	XP_012823396.1	CCP	104..156	CDD:153056	26/52 (50%)
		PBP1_GABAb_receptor	176..575	CDD:380589	349/398 (88%)
		7tmC_GABA-B-R1	595..870	CDD:320418	228/274 (83%)
		TM helix 1	595..620	CDD:320418	19/24 (79%)
		TM helix 2	632..653	CDD:320418	14/20 (70%)
		TM helix 3	669..693	CDD:320418	22/23 (96%)
		TM helix 4	718..738	CDD:320418	13/19 (68%)
		TM helix 5	774..800	CDD:320418	23/25 (92%)
		TM helix 6	809..832	CDD:320418	22/22 (100%)
		TM helix 7	839..864	CDD:320418	21/24 (88%)