DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAB1 and pico

DIOPT Version :9

Sequence 1:	XP_016863455.1	Gene:	GAB1 / 2549	HGNCID:	4066	Length:	738	Species:	Homo sapiens
Sequence 2:	NP_608363.1	Gene:	pico / 33003	FlyBaseID:	FBgn0261811	Length:	1162	Species:	Drosophila melanogaster

Alignment Length:	751	Identity:	152/751 - (20%)
Similarity:	223/751 - (29%)	Gaps:	294/751 - (39%)

- Green bases have known domain annotations that are detailed below.

Human     6 LYKK---KKAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLC--QQVDAGLTFNKK- 64
            ||.|   ||.|||..|||||..       |.|:..:..|....:..|||.  ..|..||.:.||
  Fly   500 LYMKADPKKGWKRYHFVLRSSG-------LYYFPKEKTKNTRDLACLNLFHGHNVYTGLGWRKKW 557

Human    65 EFENSYIFDINTID---------RIFYLVADSEEEMNKWVRCI--C---------------DICG 103
            :....|.|....:.         .:..|.|:....:::|:..|  |               |:|
  Fly   558 KSPTDYTFGFKAVGDSSLGKSCRSLKMLCAEDLPTLDRWLTAIRVCKYGKQLWDSHKSLLEDLC- 621

Human   104 FNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQ 168
              .:.:|.|.....:....::...:|::|.||.....|||.
  Fly   622 --LSRDDAVSQSSFAASMRSESISSISSAVPSQCGSVSSAI------------------------ 660

Human   169 DYLLLINCQSKKPEPTSQGSSFVSEEGEEYLLLED---FESK--------------TIPLQTHAD 216
                     |.....||..:|..|.......|.:|   |:|:              .:||.|...
  Fly   661 ---------SSMSNSTSGRTSRASSSSSSGCLSDDNNAFDSEFTTGTIKRKPSMKPNLPLTTMTR 716

Human   217 SAKSTSSETDCNDNVPSHKNP------------ASSQSKHGMNGFFQQQMIYDSPPSRAPSASVD 269
            ..|.....|.|........:|            ..||..:| :|..:::      |...|.|:|
  Fly   717 QLKEVGEITICESAGGDASSPERSGTLTRRHSRRKSQESNG-SGTLKRR------PIAVPVATV- 773

Human   270 SSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIP 334
                      .....|..|.|||.:...    :||:.|.|:..:           |.||::..:
  Fly   774 ----------VKQTEPMGSASSTSSSSN----STPTPTPSICAK-----------PPPGDSASL- 812

Human   335 RTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDR----SPVETCSIPRTASDTD---SSYCIPTA 392
                  ....|..||::|  |||.||....:.|:    |.:...|:|......|   .:|..|:
  Fly   813 ------MCSSTLSLDSLP--PPPPPPALDGSEDQDVYGSQLSLASLPPPPPPEDVLAMNYAEPS- 868

Human   393 GMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEEL 457
              |||....:||                  |...|:..                   ||:...
  Fly   869 --SPSTPTPMST------------------PMIMPNSN-------------------GSLPPA-- 892

Human   458 DENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVP---PPAHMGFRSSPKTPP 519
                ||..|..|..:         |.|..:...|            |   ||.::|    |...|
  Fly   893 ----VPAKPMKPAVK---------QAAGGLKAAP------------PYKAPPDYVG----PALLP 928

Human   520 RRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLP 584
            ..|:|    .|||..:.:.   ...||.:||                   |:...|.|:
  Fly   929 GPPLP----PPPPAQKKVS---FADSPVLLR-------------------RKMCSPEPV------ 961

Human   585 EWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFG 649
                  .|.|||.|..               |.||::|:..::   :.|.| .|.|.........
  Fly   962 ------LPQRSPSTTL---------------SCHSSSSAGSAY---QTYAP-GPMLPPRADVARL 1001

Human   650 SNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPR 685
            |:..:|.||.:..||          .|....|.|||
  Fly  1002 SSLSNGSSSEVTSPK----------RLQESASNPPR 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAB1	XP_016863455.1	None
pico	NP_608363.1	GRB7_RA	364..451	CDD:176382
		PH_APBB1IP	489..614	CDD:269961	31/120 (26%)
		PH	494..605	CDD:278594	31/111 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900