DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and Nedd4

DIOPT Version :9

Sequence 1:	XP_017450968.1	Gene:	Nedd4 / 25489	RGDID:	3157	Length:	1223	Species:	Rattus norvegicus
Sequence 2:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster

Alignment Length:	1045	Identity:	446/1045 - (42%)
Similarity:	552/1045 - (52%)	Gaps:	263/1045 - (25%)

- Green bases have known domain annotations that are detailed below.

  Rat   395 ASPCLPTTPDTDSHVNIRGELERPNSQRSRGRAALQRSV--SLGGTYPNVSCLSSLKHSCSKGGP 457
            |:..|| .|.:.|.| ..|::.||..:|.....|.|:..  ..|..|.....|:::..|   |..
  Fly    10 AAAALP-VPSSSSSV-AGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDS---GDS 69

  Rat   458 SQLLIKFASG------------------------NDGKVDSF------------WRE----RDLT 482
            ..|.|...:|                        .|..:||.            |.|    |...
  Fly    70 CHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKP 134

  Rat   483 NELSGV-------RKTRDDFLGQVDVPLYPLPTENPRM---ERPYTFKDFVLHPR---SHKSRVK 534
            :|...|       |.|||||||.|::.|..||||....   |:.||     |.||   ..|||:|
  Fly   135 SEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIK 194

  Rat   535 GYLRLKMTYL--------PKNGSDDENADQAEELEPGWVVLDQPDAATHLQHPPEPSP------L 585
            |.||:...::        |.:|:.|...:..|....|         .|..|  |.|.|      |
  Fly   195 GTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAG---------ETSAQ--PHPFPTGGHDAL 248

  Rat   586 PPGWEERQDVLGRTYYVNHESRTTQWKRP---------SPEDDLTDD------------ENG--- 626
            |.|||||||..||||||||.:|||||.||         |.:|.|..|            |:|
  Fly   249 PAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSA 313

  Rat   627 ---------DIQLQAQRAFTTR-------------------RQIS------EDVD---------- 647
                     |....|..|:|.:                   .||:      ||.|
  Fly   314 DSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVY 378

  Rat   648 ----GPDNHESPE----------------------------------------NW---------- 658
                .|..|..||                                        .|
  Fly   379 NSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQ 443

  Rat   659 --------------------EIVREDENTMYSGQAVQSPPSGHPDVQVRLAEELDTRLTMYGNPA 703
                                ::....:...:.||..|.        |.|.:.| ||..|...||:
  Fly   444 LHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQ--------QHRPSNE-DTDHTDSHNPS 499

  Rat   704 -TSQPVTSSNHSSRGGSSQTCIFEEQPTLPVLLPTSSG----LPPGWEEKQDDRGRSYYVDHNSK 763
             .|.|.|..|..           |:...:|.:...:.|    |||.|..:....||::::||.|:
  Fly   500 DISAPSTRRNSE-----------EDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASR 553

  Rat   764 TTTWSKPTMQDDPRSKIPAHLRGKTPVDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPR 828
            .|||.      |||:...:.:..:|....:||||||.|||||.|||||||:|:||.:.|||||||
  Fly   554 RTTWI------DPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPR 612

  Rat   829 MQNVAITGPAVPYSRDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADFLK 893
            :.|..|.|.|||||||||:|||:|:..::|.|::|||||:::||.:|||||||.|..|.:.|.||
  Fly   613 LSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLK 677

  Rat   894 ARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF 958
            .:||:||:||.||||||:|||||:|:||||||||||||||||.||||||||..||||||:|||||
  Fly   678 TKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYF 742

  Rat   959 KFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRF 1023
            |||||:||||||||||||.|||||||||||||.|.|.||||||:|||:||.||.||||..|:|.|
  Fly   743 KFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTF 807

  Rat  1024 IIDEELFGQTHQHELKTGGSEVVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 1088
            .:||::|||..|||||.||:.:.|||:||.|||.|||:||||.|:::||::|.:||..:||.:||
  Fly   808 CLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLI 872

  Rat  1089 KIFDENELELLMCGLGDVDVNDWREHTKYKNGYSLNHQVIHWFWKAVLMMDSEKRIRLLQFVTGT 1153
            |||||:||||||||:.::||.||||:|.||..|.:||.:|.|||:|||...:|.|.|||||||||
  Fly   873 KIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGT 937

  Rat  1154 SRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQG 1218
            ||||||||.|||||||||.||:|:||||:..||||||||||||||||.:.:|.|||..|||.:||
  Fly   938 SRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQG 1002

  Rat  1219 FDGVD 1223
            |.|||
  Fly  1003 FAGVD 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	XP_017450968.1	None
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	50/199 (25%)
		WW	248..277	CDD:278809	12/137 (9%)
		WW	531..560	CDD:278809	25/28 (89%)
		WW	581..613	CDD:197736	27/31 (87%)
		HECTc	650..1003	CDD:238033	128/189 (68%)
		HECTc	674..1003	CDD:214523	112/165 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	463	1.000	Domainoid score	I454
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	866	1.000	Inparanoid score	I397
OMA	1	1.010	-	-		QHG49869
OrthoDB	1	1.010	-	-		D142537at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm45750
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1682
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980