DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo1e and Mhc

DIOPT Version :9

Sequence 1:	NP_775124.1	Gene:	Myo1e / 25484	RGDID:	3144	Length:	1107	Species:	Rattus norvegicus
Sequence 2:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster

Alignment Length:	920	Identity:	287/920 - (31%)
Similarity:	471/920 - (51%)	Gaps:	94/920 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat    17 KHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQ 81
            |...::||..::.:....::.||::||....|:||.|...:::||:|:.|.:..:..:||:|..:
  Fly    84 KFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRR 148

  Rat    82 YENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQH----- 141
            .|.||||:|::|..|.:|:.:..||.::|:||||||||...|.:::|.:.| |...|...
  Fly   149 NEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-GASKKTDEAAKSK 212

  Rat   142 --VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNP 204
              ::|.::|:||:||||||||||||:|||||||:..|.|.|.|:..|..|..:||||:||:.:..
  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277

  Rat   205 GERSFHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFS 269
            .|||:|||||::.|:.|..|....:|...|.|::...|...|..|||..:|..|..|.:::|...
  Fly   278 LERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTK 342

  Rat   270 EEQTLVLQIVAGILHLGNINFKEVG--NYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKW 332
            :|:..|.:|.|.::|:|.:.||:.|  ..|..:.||.....:.|.|.:...|.:.|...::  |.
  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRI--KV 405

  Rat   333 GGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAME-KDHEEYNIGVLDIYGFEIFQ 396
            |  :|.:....||:|...:..||.|.:..|:|.:||...|:.:: :...::.||||||.|||||:
  Fly   406 G--NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFE 468

  Rat   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVC-DLIESKVNPPGIM 460
            .|||||.||||.||||||.|.......|||||.:|||.|..|::..:.:.| ||||   .|.||:
  Fly   469 YNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE---KPMGIL 530

  Rat   461 SILDDVCATMHAVGEGADQTLLQKL-QMQIGSHEHFNS------WNQG--FIIHHYAGKVSYDMD 516
            |||::......|    .|||..:|| ...:|....|..      ..|.  |.|.||||.|||::.
  Fly   531 SILEEESMFPKA----TDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNIT 591

  Rat   517 GFCERNRDVLFMDLIELMQSSELPFIKSLFPENL------------QADKKGRPTTAGSKIKKQA 569
            |:.|:|:|.|...:::..:.|:...:..:|.::.            :..|.|...|..|..|:|.
  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQL 656

  Rat   570 NDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQ 634
            |.|::||....||::|||.|||.|:|...:...|.||:...|:.|.||:.|.|:..|.::..|..
  Fly   657 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKM 721

  Rat   635 RYAILTKATWPVWRGDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYA 699
            ||.|:..........|:|...: :::.:::..||::||.:|||.:| ..|..:||.|:.:.....
  Fly   722 RYKIMCPKLLQGVEKDKKATEI-IIKFIDLPEDQYRLGNTKVFFRA-GVLGQMEEFRDERLGKIM 784

  Rat   700 RVIQKTWRKFVARKKYVQMREDASDLLLNKKERR-----------------RNSINRNFIGDYIG 747
            ..:|...|.:::||.:.:::|....|.:.::..|                 :..:|.:.|.|.|.
  Fly   785 SWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIA 849

  Rat   748 MEEHPELQQFVGKREKIDFADIVTKYDRRFKGVKRDLLLTPKCLY--LIGREKVKQGPDKGLVKE 810
                 .|::...|.|::..|::  |..:..:.:...||.....|.  |.|        :||.:::
  Fly   850 -----RLEEKAKKAEELHAAEV--KVRKELEALNAKLLAEKTALLDSLSG--------EKGALQD 899

  Rat   811 VLKRKIEVERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLTKRYEEKTQKQLP--LKF 873
            ..:|        :..|:..::|:    |.:...:.|.:.:.|.......:.::|..:::.  .|.
  Fly   900 YQER--------NAKLTAQKNDL----ENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKD 952

  Rat   874 SNTLELKLKK 883
            ...|||.::|
  Fly   953 IEDLELNVQK 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo1e	NP_775124.1	MYSc	14..692	CDD:214580	251/706 (36%)
		MYSc_Myo1	33..679	CDD:276829	244/677 (36%)
		Actin-binding. /evidence=ECO:0000255	581..591		6/9 (67%)
		Myosin_TH1	719..899	CDD:283635	31/186 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	920..1052
		SH3_MyoIe_If_like	1055..1106	CDD:212761
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	251/706 (36%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	244/677 (36%)
		Myosin_tail_1	842..1897	CDD:279860	27/148 (18%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000