Protein Alignment Myo1e and Mhc

DIOPT Version :10

• Sequence 1: NP_775124.1
• Gene: Myo1e / 25484
• RGDID: 3144
• Length: 1107
• Species: Rattus norvegicus
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 920
• Identity: 290/920 - (31%)
• Similarity: 476/920 - (51%)
• Gaps: 94/920 - (10%)

  Rat    17 KHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQ 81
            |:...:||..|:.:.::|::.||::||.:..|:||.|...:::||:|:.|.:..:..:||:|..:
  Fly    84 KYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRR 148

  Rat    82 YENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQH----- 141
            .|.||||:|::|..|.:|:.:..||.::|:||||||||...|.:::|.:.| |...|...
  Fly   149 NEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-GASKKTDEAAKSK 212

  Rat   142 --VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNP 204
              ::|.::|:||:||||||||||||:|||||||:..|.|.|.|:..|..|..:||||:||:.:..
  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277

  Rat   205 GERSFHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFS 269
            .|||:|||||::.|:.|..|....:|...|.|::...|...|..|||..:|..|..|.:::|...
  Fly   278 LERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTK 342

  Rat   270 EEQTLVLQIVAGILHLGNINFKEVG--NYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKW 332
            :|:..|.:|.|.::|:|.:.||:.|  ..|..:.||.....:.|.|.:...|.:.|...::  |.
  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRI--KV 405

  Rat   333 GGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAME-KDHEEYNIGVLDIYGFEIFQ 396
            |  :|.:....||:|...:..||.|.:..|:|.:||...|:.:: :...::.||||||.|||||:
  Fly   406 G--NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFE 468

  Rat   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVC-DLIESKVNPPGIM 460
            .|||||.||||.||||||.|.......|||||.:|||.||.|::..:..:| ||||   .|.||:
  Fly   469 YNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE---KPMGIL 530

  Rat   461 SILDDVCATMHAVGEGADQTLLQKL-QMQIGSHEHFNS------WNQG--FIIHHYAGKVSYDMD 516
            |||::......|    .|||..:|| ...:|....|..      ..|.  |.|.||||.|||::.
  Fly   531 SILEEESMFPKA----TDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNIT 591

  Rat   517 GFCERNRDVLFMDLIELMQSSELPFIKSLFPENL------------QADKKGRPTTAGSKIKKQA 569
            |:.|:|:|.|...:::..:.|:...:..:|.::.            :..|.|...|..|..|:|.
  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQL 656

  Rat   570 NDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQ 634
            |.|::||....||::|||.|||.|:|...:...|.||:...|:.|.||:.|.|:..|.::..|..
  Fly   657 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKM 721

  Rat   635 RYAILTKATWPVWRGDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYA 699
            ||.|:..........|:|...: :::.:::..||::||.:|||.:| ..|..:||.|:.:.....
  Fly   722 RYKIMCPKLLQGVEKDKKATEI-IIKFIDLPEDQYRLGNTKVFFRA-GVLGQMEEFRDERLGKIM 784

  Rat   700 RVIQKTWRKFVARKKYVQMREDASDLLLNKKERR-----------------RNSINRNFIGDYIG 747
            ..:|...|.:::||.:.:::|....|.:.::..|                 :..:|.:.|.|.|.
  Fly   785 SWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIA 849

  Rat   748 MEEHPELQQFVGKREKIDFADIVTKYDRRFKGVKRDLLLTPKCLY--LIGREKVKQGPDKGLVKE 810
                 .|::...|.|::..|::  |..:..:.:...||.....|.  |.|        :||.:::
  Fly   850 -----RLEEKAKKAEELHAAEV--KVRKELEALNAKLLAEKTALLDSLSG--------EKGALQD 899

  Rat   811 VLKRKIEVERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLTKRYEEKTQKQLP--LKF 873
            ..:|        :..|:..::|:    |.:...:.|.:.:.|.......:.::|..:::.  .|.
  Fly   900 YQER--------NAKLTAQKNDL----ENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKD 952

  Rat   874 SNTLELKLKK 883
            ...|||.::|
  Fly   953 IEDLELNVQK 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo1e	NP_775124.1	MYSc_Myo1	33..679	CDD:276829	246/677 (36%)
		Actin-binding. /evidence=ECO:0000255	581..591		6/9 (67%)
		Myosin_TH1	719..920	CDD:461801	31/186 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	920..1052
		SH3_MyoIe_If_like	1055..1106	CDD:212761
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	246/677 (36%)
		Myosin_tail_1	842..1922	CDD:460256	27/148 (18%)