DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps35 and Vps35

DIOPT Version :9

Sequence 1:	NP_001099188.2	Gene:	Vps35 / 25479	RGDID:	1589784	Length:	796	Species:	Rattus norvegicus
Sequence 2:	NP_726175.3	Gene:	Vps35 / 37536	FlyBaseID:	FBgn0034708	Length:	822	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	492/809 - (60%)
Similarity:	635/809 - (78%)	Gaps:	24/809 - (2%)

- Green bases have known domain annotations that are detailed below.

  Rat     4 TQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYM 68
            |..:..|:|||||.|||...:.|:|||...|||.:::|:||.||.||||||||:|||||||||||
  Fly    21 TMPNGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYM 85

  Rat    69 AISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDL 133
            |:::||.:||:||::   |..|..||||||||:..|:||||||||||:||:|:.|..::.|||||
  Fly    86 AVTNELCHLELYLSE---KIDKKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDL 147

  Rat   134 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQ 198
            ||||||||||||||||||||||||||||||. ...:.|..|::.|::||||.|||||||||||||
  Fly   148 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDV-MVEENEHEGNVYDAIDFVLTNFAEMNKLWVRMQ 211

  Rat   199 HQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLM 263
            |||||.::.:||:||:||:||||||||||||||...:|.|::::|.|||||||:||||:||||||
  Fly   212 HQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQEYLM 276

  Rat   264 ECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPG-------IPAE 321
            |||||||||||||:||:|||::||:|...||||||||:||:|||.:..|.....       ||||
  Fly   277 ECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDAIIPAE 341

  Rat   322 IKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLE 386
            ::||::||.|||.::|:|.|||.||.:||||:|::||.|.||||||||||||.||.:|..::|:.
  Fly   342 VELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQRMNMN 406

  Rat   387 HIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTEI 451
            :|:...:|::||:|||:|.:|.|||.||:::|::|.||.|.|||.||||::.|::.|:||..|.:
  Fly   407 NISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLVMNILDNETLV 471

  Rat   452 VSQDQVDSIMNLVSTLIQDQPDQPVED--------PDPEDFADEQSLVGRFIHLLRSEDPDQQYL 508
            .:.||.||::.:::.||:|. |...|:        ||.|:||:||.:|.|||||:||::||.||.
  Fly   472 PTADQADSLLTIITPLIKDD-DTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMRSDEPDMQYK 535

  Rat   509 ILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSQMDDKWEKKCQKIFSFAHQTISALIK 573
            :|.|||||.|.||.||::..|||||||||||||:||..::.|:.|:||||||..:.|.|||||.|
  Fly   536 MLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQKIVQYCHSTISALAK 600

  Rat   574 AELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDELSDSKAQLAAITLIIGTFERM 638
            |:||:|.|||:|||||..||||:.||||||||||:|||||||||:|||||||||||||:.|||:|
  Fly   601 ADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITLIMSTFEQM 665

  Rat   639 KCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKA 703
            .||.|||.|||||.||||||||||||||.|.|..||.|||||:   :||||:...||.::||||.
  Fly   666 SCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGK---QNGEEMRDEKRTLDCLKKG 727

  Rat   704 LKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINK 768
            .:||:||:|..:||||::|:||.|::::|:.|..:|:.:|||||.|:.|:|||||.||||:||..
  Fly   728 ARIASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKVNEELPNLEPSEETKQIES 792

  Rat   769 HFHNTLEHLRSRRESPESEGPI-YEGLIL 796
            |:.|||.|:|||.||.:|...: :.|:.|
  Fly   793 HYKNTLAHIRSRMESNDSSLEVSFAGITL 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_001099188.2	Vps35	15..752	CDD:397615	462/751 (62%)
Vps35	NP_726175.3	Vps35	32..777	CDD:281615	468/759 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354096
Domainoid	1	1.000	930	1.000	Domainoid score	I36
eggNOG	1	0.900	-	-		E1_KOG1107
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6221
Inparanoid	1	1.050	982	1.000	Inparanoid score	I295
OMA	1	1.010	-	-		QHG54026
OrthoDB	1	1.010	-	-		D115466at33208
OrthoFinder	1	1.000	-	-		FOG0003201
OrthoInspector	1	1.000	-	-		oto97487
orthoMCL	1	0.900	-	-		OOG6_101945
Panther	1	1.100	-	-	LDO	PTHR11099
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2604
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770