DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Man2a1 and LManI

DIOPT Version :9

Sequence 1:	NP_037111.2	Gene:	Man2a1 / 25478	RGDID:	3038	Length:	1148	Species:	Rattus norvegicus
Sequence 2:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster

Alignment Length:	1089	Identity:	277/1089 - (25%)
Similarity:	452/1089 - (41%)	Gaps:	261/1089 - (23%)

- Green bases have known domain annotations that are detailed below.

  Rat   165 LQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSSRKFIWSEISYLAKW 221
            :.|.:|||||:|.|||||.:.|:   ::|     .|||.:.:|.:|.:||||:||..|..:.|||
  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66

  Rat   222 WDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKNLG--VKPRSG 284
            :.......:.|||.|:..|:||...|.|.|.||||.||.:::||...|.::|:...|  .:|..|
  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131

  Rat   285 WAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLGSTTDILCHMMP 349
            |.|||||||..|..:..:..|:.....|:.|..||...|...:|..|:.:..| ..::|...|:
  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESL-KNSNIFTGML- 194

  Rat   350 FYSYDIPHTCGPDPKICCQFDFKRLP---GGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSK 411
            :..|..|      |..|...:.:..|   |..|            ..||.:|....:|..:..||
  Fly   195 YNHYSAP------PGFCFDINCEDAPIIDGESY------------DNNVDARVSEFIDYVKNMSK 241

  Rat   412 LFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQPHL--KVKIQFGTLSDYFDALEKSV 474
            .:|:..::.|:||||   :|.:..:.::|.::|..|:|.:...  :|.:.:.|.|.|...|.:.
  Fly   242 SYRSTHIMVPMGDDF---QYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQL- 302

  Rat   475 AAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRLRTAEILYHLALKQAQ 539
                   :..:|..:.|||.|:.....||:|||||||..||..|......:|.:.|..||.....
  Fly   303 -------KQTWPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGT 360

  Rat   540 KYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFL 604
            :|       |.....|::|   :|:.|||||:|||.|..|..||...||:::...|....|:
  Fly   361 QY-------SEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDA--- 412

  Rat   605 LILKDKKLYQSDPSKAFLEMDTKQSSQDSLPKKNIIQLSAQEPRYLVVYNPFEQERHSVVSVRVN 669
              |:......|...::.||::....:.......|:|         :.:.||........|.|...
  Fly   413 --LRSLTNLTSGEFESCLELNISVCAFTQDTANNVI---------VTLVNPLAHSSTQYVRVPAK 466

  Rat   670 SATVKVLSDLGKAVEVQVSAV-WKDM---RTTSQAAYEVAFLAHLPPLGLKVYKILESQSSSSHL 730
            :....|..:.|:.|..:|..| |:.:   ...:...:|:.|.|.:..:...:.::|.|.
  Fly   467 NENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKIANFLIRVLPSP------ 525

  Rat   731 ADYFLYNNDGQAESGIFHMKNMVD---------SGDAITIENSFLTLGFDRS--GLME-KVRRKE 783
                               ||:.:         |.|.:|:|.|.:.|.||.:  ||.. |:....
  Fly   526 -------------------KNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGLKTVKMNGFT 571

  Rat   784 DNKQQELKVQFLWYGTT--NKRDKSGAYLFLPDGQGQPYVSLRTPFVRVTRGRIYSDVTCFLEHV 846
            :|.||...:...:.|..  :|...||||:|.|                      |.|:    |.|
  Fly   572 ENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP----------------------YGDI----EIV 610

  Rat   847 THKVRLYHIQGIEGQSME------VSNIVDIRSVHNR------------------EIVMRISSKI 887
            .:||.|....|.:.:.:.      :|.::.|....||                  ||:.|.||.|
  Fly   611 NNKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNI 675

  Rat   888 NNQNRYYTDLNGYQIQPRR---------TMAKLPLQANVYPMSTMAYIQDAAHRLTLLSAQSLGA 943
            :::.::|||.||.:|..|.         .|:: .:..|.||::....:||...|:|||:.::.|.
  Fly   676 SSKGKFYTDSNGREILERERNQREHFTPDMSE-AISGNYYPVTGQISLQDDEKRITLLNDRAQGG 739

  Rat   944 SSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLFR-----ILLEKRNGMNMEEDKKSPVSY 1003
            :|:..|::|:.:.|||:.||..|:|:.:::.:....|..     ::|:..:|...:.
  Fly   740 TSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILDAVDGKPNQR-------- 796

  Rat  1004 PSLLSHMTS-------------AFLNHPFLPMVLSGQLPSPAIELL-----SEFRLLQSSLPCDI 1050
              ||.|...             |.:|...:|....  :|. ::|||     |:.::|       |
  Fly   797 --LLQHQLDQHFWKFFSKSNGVASVNRNMIPDFFG--IPE-SVELLSLEPYSKDQIL-------I 849

  Rat  1051 HLVNLRTIQSKVG----------KGYSDEAALILHRKVFDCQLSSRAMGLPCSTTQGKMSIP--K 1103
            .|.|..|..:.|.          .||          ::::            :|..|.|.:.  |
  Fly   850 RLENFNTEGNVVSFNIYPLFESLDGY----------QIWE------------TTLDGNMLLEDVK 892

  Rat  1104 LFNNFAVE--SFIPSSLSLMHSP--PDAQNTS------EVSLSPMEIST 1142
            .| .||.:  ..||||:...|:|  |...|::      .|:|.||:|.|
  Fly   893 RF-KFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRT 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Man2a1	NP_037111.2	PLN02701	127..1148	CDD:178304	277/1089 (25%)
		GH38N_Man2A1	164..507	CDD:212131	109/356 (31%)
		Alpha-mann_mid	502..587	CDD:214875	33/84 (39%)
		Glyco_hydro_38C	733..1142	CDD:285047	112/500 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1148		10/30 (33%)
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	95/296 (32%)
		Alpha-mann_mid	323..398	CDD:286360	33/84 (39%)
		Glyco_hydro_38C	536..941	CDD:285047	111/475 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810