Protein Alignment Man2a1 and LManI

DIOPT Version :10

• Sequence 1: NP_037111.2
• Gene: Man2a1 / 25478
• RGDID: 3038
• Length: 1148
• Species: Rattus norvegicus
• Sequence 2: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Alignment Length: 1089
• Identity: 277/1089 - (25%)
• Similarity: 452/1089 - (41%)
• Gaps: 261/1089 - (23%)

  Rat   165 LQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSSRKFIWSEISYLAKW 221
            :.|.:|||||:|.|||||.:.|:   ::|     .|||.:.:|.:|.:||||:||..|..:.|||
  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66

  Rat   222 WDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKNLG--VKPRSG 284
            :.......:.|||.|:..|:||...|.|.|.||||.||.:::||...|.::|:...|  .:|..|
  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131

  Rat   285 WAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLGSTTDILCHMMP 349
            |.|||||||..|..:..:..|:.....|:.|..||...|...:|..|:.:..| ..::|...|:
  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESL-KNSNIFTGML- 194

  Rat   350 FYSYDIPHTCGPDPKICCQFDFKRLP---GGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSK 411
            :..|..|      |..|...:.:..|   |..|            ..||.:|....:|..:..||
  Fly   195 YNHYSAP------PGFCFDINCEDAPIIDGESY------------DNNVDARVSEFIDYVKNMSK 241

  Rat   412 LFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQPHL--KVKIQFGTLSDYFDALEKSV 474
            .:|:..::.|:||||   :|.:..:.::|.::|..|:|.:...  :|.:.:.|.|.|...|.:.
  Fly   242 SYRSTHIMVPMGDDF---QYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQL- 302

  Rat   475 AAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRLRTAEILYHLALKQAQ 539
                   :..:|..:.|||.|:.....||:|||||||..||..|......:|.:.|..||.....
  Fly   303 -------KQTWPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGT 360

  Rat   540 KYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFL 604
            :|       |.....|::|   :|:.|||||:|||.|..|..||...||:::...|....|:
  Fly   361 QY-------SEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDA--- 412

  Rat   605 LILKDKKLYQSDPSKAFLEMDTKQSSQDSLPKKNIIQLSAQEPRYLVVYNPFEQERHSVVSVRVN 669
              |:......|...::.||::....:.......|:|         :.:.||........|.|...
  Fly   413 --LRSLTNLTSGEFESCLELNISVCAFTQDTANNVI---------VTLVNPLAHSSTQYVRVPAK 466

  Rat   670 SATVKVLSDLGKAVEVQVSAV-WKDM---RTTSQAAYEVAFLAHLPPLGLKVYKILESQSSSSHL 730
            :....|..:.|:.|..:|..| |:.:   ...:...:|:.|.|.:..:...:.::|.|.
  Fly   467 NENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKIANFLIRVLPSP------ 525

  Rat   731 ADYFLYNNDGQAESGIFHMKNMVD---------SGDAITIENSFLTLGFDRS--GLME-KVRRKE 783
                               ||:.:         |.|.:|:|.|.:.|.||.:  ||.. |:....
  Fly   526 -------------------KNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGLKTVKMNGFT 571

  Rat   784 DNKQQELKVQFLWYGTT--NKRDKSGAYLFLPDGQGQPYVSLRTPFVRVTRGRIYSDVTCFLEHV 846
            :|.||...:...:.|..  :|...||||:|.|                      |.|:    |.|
  Fly   572 ENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP----------------------YGDI----EIV 610

  Rat   847 THKVRLYHIQGIEGQSME------VSNIVDIRSVHNR------------------EIVMRISSKI 887
            .:||.|....|.:.:.:.      :|.::.|....||                  ||:.|.||.|
  Fly   611 NNKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNI 675

  Rat   888 NNQNRYYTDLNGYQIQPRR---------TMAKLPLQANVYPMSTMAYIQDAAHRLTLLSAQSLGA 943
            :::.::|||.||.:|..|.         .|:: .:..|.||::....:||...|:|||:.::.|.
  Fly   676 SSKGKFYTDSNGREILERERNQREHFTPDMSE-AISGNYYPVTGQISLQDDEKRITLLNDRAQGG 739

  Rat   944 SSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLFR-----ILLEKRNGMNMEEDKKSPVSY 1003
            :|:..|::|:.:.|||:.||..|:|:.:::.:....|..     ::|:..:|...:.
  Fly   740 TSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILDAVDGKPNQR-------- 796

  Rat  1004 PSLLSHMTS-------------AFLNHPFLPMVLSGQLPSPAIELL-----SEFRLLQSSLPCDI 1050
              ||.|...             |.:|...:|....  :|. ::|||     |:.::|       |
  Fly   797 --LLQHQLDQHFWKFFSKSNGVASVNRNMIPDFFG--IPE-SVELLSLEPYSKDQIL-------I 849

  Rat  1051 HLVNLRTIQSKVG----------KGYSDEAALILHRKVFDCQLSSRAMGLPCSTTQGKMSIP--K 1103
            .|.|..|..:.|.          .||          ::::            :|..|.|.:.  |
  Fly   850 RLENFNTEGNVVSFNIYPLFESLDGY----------QIWE------------TTLDGNMLLEDVK 892

  Rat  1104 LFNNFAVE--SFIPSSLSLMHSP--PDAQNTS------EVSLSPMEIST 1142
            .| .||.:  ..||||:...|:|  |...|::      .|:|.||:|.|
  Fly   893 RF-KFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRT 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Man2a1	NP_037111.2	PLN02701	127..1148	CDD:178304	277/1089 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1148		10/30 (33%)
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	95/296 (32%)
		PLN02701	4..765	CDD:178304	233/867 (27%)