DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lhcgr and Lgr4

DIOPT Version :9

Sequence 1:	NP_037110.1	Gene:	Lhcgr / 25477	RGDID:	3007	Length:	700	Species:	Rattus norvegicus
Sequence 2:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	698	Identity:	162/698 - (23%)
Similarity:	271/698 - (38%)	Gaps:	150/698 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    38 CDCAPDGALRC--------PG--PRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSL-- 90
            |.|..|..| |        |.  |:..||.|.||        ...|..::|....|:...|||
  Fly   162 CPCRGDEIL-CRFQQLTDIPERLPQHDLATLDLT--------GNNFETIHETFFSELPDVDSLVL 217

  Rat    91 -----ERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISS 150
                 ..|.::|||.|.:       |....||::.....:||.           ...|:..::|
  Fly   218 KFCSIREIASHAFDRLAD-------NPLRTLYMDDNKLPHLPE-----------HFFPEGNQLS- 263

  Rat   151 SEFNFILEICDNLHITTIPGNAFQGMNNESV-TLKLYGNGFEEVQSHAFNGTTLISLELKENIYL 214
                 ||.:..| |:..:..:.|  :|.:.: .|.|.||.....::..|  ..|.:||:   :||
  Fly   264 -----ILILARN-HLHHLKRSDF--LNLQKLQELDLRGNRIGNFEAEVF--ARLPNLEV---LYL 315

  Rat   215 EKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTY 279
            .:.|.........|                     :||:.|.:.||    :..:...:...|..:
  Fly   316 NENHLKRLDPDRFP---------------------RTLLNLHTLSL----AYNQIEDIAANTFPF 355

  Rat   280 P------------SHC-----CAFRNL------PKKEQNF---SFSIFENFSKQCESTVRKADNE 318
            |            ||.     |...||      ..:.:.|   :|:..:|.|....:..|   .:
  Fly   356 PRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNR---FQ 417

  Rat   319 TLYSAIFEENELSGWDYDY----GFCSP--KTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILA 377
            ||.|.:.:  .|:..||.|    ..||.  ....|.|..|..:....::....||..:|::..:|
  Fly   418 TLDSRVLK--NLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIA 480

  Rat   378 IFGNLTVLFVLLTSRYKLTVPRFL-MCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGS 441
            :.|||.||......:.:..|...| :.:|:.:||.||:||.|||..|...:|:|..:...|:...
  Fly   481 VVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSG 545

  Rat   442 GCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPL 506
            .|..|||.:.|:.:.|...||::|.:|..::|..::.....::|..:.::| .|..|..:|..||
  Fly   546 VCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLL-LWGISFGLAAAPL 609

  Rat   507 V-----GISNYMKVSICLPMDVESTLSQVY---ILSILILNVVAFVVICACYIRIYFAVQNP--- 560
            :     |...|....:||.:.:....::.:   .|..:::|.::.:.|...|||:..|:::.
  Fly   610 LPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGG 674

  Rat   561 -ELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKI-------LLVLFYP 617
             ..|...::..:|.:.||::.||..|..||        ..|.|..::..:|       |.||..|
  Fly   675 MRSTHSGRENVVATRFAIIVTTDCACWLPI--------IVVKLAALSGCEISPDLYAWLAVLVLP 731

  Rat   618 VNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTS 665
            |||..||.||.:.|.||::...........|.......|.:..:||.|
  Fly   732 VNSALNPVLYTLTTAAFKQQLRRYCHTLPSCSLVNNETRSQTQTAYES 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lhcgr	NP_037110.1	leucine-rich repeat	55..78	CDD:275380	6/22 (27%)
		LRR_5	66..204	CDD:404228	29/145 (20%)
		leucine-rich repeat	79..103	CDD:275380	9/30 (30%)
		leucine-rich repeat	104..128	CDD:275380	4/23 (17%)
		LRR 1	126..150		3/23 (13%)
		leucine-rich repeat	129..150	CDD:275380	1/20 (5%)
		LRR 2	152..175		5/22 (23%)
		leucine-rich repeat	155..178	CDD:275380	5/22 (23%)
		LRR 3	176..200		6/24 (25%)
		leucine-rich repeat	179..202	CDD:275380	5/23 (22%)
		LRR 4	202..224		6/21 (29%)
		leucine-rich repeat	203..227	CDD:275380	6/23 (26%)
		LRR 5	225..248		1/22 (5%)
		leucine-rich repeat	228..248	CDD:275380	1/19 (5%)
		LRR 6	250..271		5/20 (25%)
		7tmA_LHCGR	365..638	CDD:320481	80/292 (27%)
		TM helix 1	366..390	CDD:320481	9/23 (39%)
		TM helix 2	399..420	CDD:320481	9/21 (43%)
		TM helix 3	444..466	CDD:320481	7/21 (33%)
		TM helix 4	489..505	CDD:320481	4/15 (27%)
		TM helix 5	529..552	CDD:320481	4/25 (16%)
		TM helix 6	572..594	CDD:320481	8/21 (38%)
		TM helix 7	606..631	CDD:320481	12/31 (39%)
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	55/277 (20%)
		LRR_8	188..248	CDD:290566	19/74 (26%)
		leucine-rich repeat	188..211	CDD:275380	8/30 (27%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	238..261	CDD:275380	5/33 (15%)
		LRR_8	261..320	CDD:290566	17/72 (24%)
		leucine-rich repeat	262..285	CDD:275380	7/31 (23%)
		LRR_4	284..325	CDD:289563	11/45 (24%)
		leucine-rich repeat	286..309	CDD:275380	6/24 (25%)
		LRR_4	308..348	CDD:289563	11/67 (16%)
		leucine-rich repeat	310..334	CDD:275380	8/47 (17%)
		leucine-rich repeat	335..357	CDD:275380	4/25 (16%)
		LRR_8	356..416	CDD:290566	11/62 (18%)
		leucine-rich repeat	358..381	CDD:275380	3/22 (14%)
		LRR_4	381..421	CDD:289563	9/42 (21%)
		leucine-rich repeat	382..405	CDD:275380	3/22 (14%)
		leucine-rich repeat	406..427	CDD:275380	5/25 (20%)
		7tm_1	483..741	CDD:278431	71/266 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810