DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lhcgr and rk

DIOPT Version :9

Sequence 1:	NP_037110.1	Gene:	Lhcgr / 25477	RGDID:	3007	Length:	700	Species:	Rattus norvegicus
Sequence 2:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster

Alignment Length:	724	Identity:	242/724 - (33%)
Similarity:	367/724 - (50%)	Gaps:	115/724 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat     7 ALRQLLVLAVL-------------LLKPSQLQSRELSGSRCPEPCDCAPDGALRCPG----PRAG 54
            ||:.|..|.||             |.|.||||...::.:|            ||...    ||:
  Fly   342 ALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNR------------LRWINDTELPRS- 393

  Rat    55 LARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLE---RIEANAFDNLLNLSELLIQNTKNLL 116
            :..|.:...|:..|...||||::::.|:.:|...:|.   .:||.....:|.|....||.
  Fly   394 MQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQE----- 453

  Rat   117 YIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESV 181
             :........||||.|.:....::.:|:   :||.....:|::..| .|..|.|..|.|:...:.
  Fly   454 -VPANLCRQTPRLKSLELKTNSLKRIPN---LSSCRDLRLLDLSSN-QIEKIQGKPFNGLKQLND 513

  Rat   182 TLKLYGNGFEEVQSHAFNG---TTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPS 243
            .|..| |..:.:...||.|   ..|:.||..|..|:   |..||.|.|....|::.:.....||.
  Fly   514 LLLSY-NRIKALPQDAFQGIPKLQLLDLEGNEISYI---HKEAFSGFTALEDLNLGNNIFPELPE 574

  Rat   244 HGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLP-------KK--------- 292
            .||.::..|...::..|:..|..:.|..:....|:|..|||||  ||       ||
  Fly   575 SGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAF--LPLVAMSSQKKTSQVQEAVL 637

  Rat   293 ---EQNFSFSIF-----------ENFSKQC--------ESTVRKADNE----------TLY-SAI 324
               :..|..:::           .|.|||.        |:.:...:.:          |.| ...
  Fly   638 FPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEY 702

  Rat   325 FEENELSGWDYDYGF------------CSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILA 377
            |||:::||....|||            ..|.::||.|.|..|.||.|:..:..||..:|::.:|:
  Fly   703 FEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLS 767

  Rat   378 IFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSG 442
            :.||.||:||||.||.|:.|||||:|||:.|||.||:||.::|.||:.|.|::...||.||....
  Fly   768 LLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVL 832

  Rat   443 CGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLV 507
            |..:||..|.:||||||||.||||||.:.||:|:.|:::|.|:.|..||..||:|:.::|.||||
  Fly   833 CQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLV 897

  Rat   508 GISNYMKVSICLPMDVES-TLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKI 571
            |:|:|.|.::|||.:..: ..|..|::|::.:|..||:.:..||:::|:|::..:....| |::|
  Fly   898 GVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTN-DSRI 961

  Rat   572 AKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQR 636
            ||:||:|:||||.|.:||:||:|:|.|.:.||::..:||..|...|:|||.|||||||.||.|::
  Fly   962 AKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKK 1026

  Rat   637 DFLLLLSRF 645
            |.:.|...|
  Fly  1027 DCVTLCKHF 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lhcgr	NP_037110.1	leucine-rich repeat	55..78	CDD:275380	7/22 (32%)
		LRR_5	66..204	CDD:404228	35/143 (24%)
		leucine-rich repeat	79..103	CDD:275380	5/26 (19%)
		leucine-rich repeat	104..128	CDD:275380	3/23 (13%)
		LRR 1	126..150		6/23 (26%)
		leucine-rich repeat	129..150	CDD:275380	4/20 (20%)
		LRR 2	152..175		6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		LRR 3	176..200		5/23 (22%)
		leucine-rich repeat	179..202	CDD:275380	6/25 (24%)
		LRR 4	202..224		8/21 (38%)
		leucine-rich repeat	203..227	CDD:275380	9/23 (39%)
		LRR 5	225..248		6/22 (27%)
		leucine-rich repeat	228..248	CDD:275380	5/19 (26%)
		LRR 6	250..271		4/20 (20%)
		7tmA_LHCGR	365..638	CDD:320481	130/273 (48%)
		TM helix 1	366..390	CDD:320481	11/23 (48%)
		TM helix 2	399..420	CDD:320481	13/20 (65%)
		TM helix 3	444..466	CDD:320481	13/21 (62%)
		TM helix 4	489..505	CDD:320481	6/15 (40%)
		TM helix 5	529..552	CDD:320481	7/22 (32%)
		TM helix 6	572..594	CDD:320481	14/21 (67%)
		TM helix 7	606..631	CDD:320481	14/24 (58%)
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	13/52 (25%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	6/16 (38%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380	3/5 (60%)
		LRR_RI	327..567	CDD:238064	65/251 (26%)
		leucine-rich repeat	349..371	CDD:275380	5/21 (24%)
		LRR_8	370..425	CDD:290566	17/67 (25%)
		leucine-rich repeat	372..393	CDD:275380	6/32 (19%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	17/76 (22%)
		leucine-rich repeat	441..464	CDD:275378	4/28 (14%)
		LRR_8	487..545	CDD:290566	16/59 (27%)
		leucine-rich repeat	487..510	CDD:275380	7/23 (30%)
		leucine-rich repeat	511..534	CDD:275380	6/23 (26%)
		LRR_8	533..589	CDD:290566	16/58 (28%)
		leucine-rich repeat	535..558	CDD:275380	9/25 (36%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	66/127 (52%)
		7tm_1	770..1017	CDD:278431	119/247 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810