DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lamb2 and LanB1

DIOPT Version :9

Sequence 1:	NP_037106.1	Gene:	Lamb2 / 25473	RGDID:	2988	Length:	1801	Species:	Rattus norvegicus
Sequence 2:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster

Alignment Length:	1802	Identity:	742/1802 - (41%)
Similarity:	996/1802 - (55%)	Gaps:	110/1802 - (6%)

- Green bases have known domain annotations that are detailed below.

  Rat    45 CSRGSCYPATGDLLVGRADRLTASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPNSH 109
            |.|.|||||||:||:||.:|||||||||||||:.:||:||||| |||||||:|.. :..|...:|
  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQD-KKCFLCDTREE-TKHDPYKNH 111

  Rat   110 RIQNVVTSFAPQRR-TAWWQSENGVPMVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGR 173
            ||..::....|... ..|||||||....||||||||||||||||:||.|||||||.:|||.|||:
  Fly   112 RIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQ 176

  Rat   174 TWRVYRYFSYDCGADFPGIPLAPPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSR 238
            ||.:||||:|||...|||:|.. .....||:|.||||.:|||..||||:|||.|.|.:.|||:..
  Fly   177 TWHIYRYFAYDCKESFPGVPTV-LENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEH 240

  Rat   239 IQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYELVIRGNCFCYGHASQCAPAPGAPA 303
            :||.||:||||:.:|:||.|||||||.|.|..|||||.:..:|:||:|.||||||||.|...|.:
  Fly   241 VQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFS 305

  Rat   304 HA---EGMVHGACICKHNTRGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGHSHSCHFDMAV 365
            .|   :|||||.|.|.|||:|:|||:|:||:.||||.||....|:||:|||||.|:.|||||.||
  Fly   306 QADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAV 370

  Rat   366 YLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDMRDPAACRPCDCDPMGSQDGGRCDSHD 430
            :.|||.|||||||.|.|||.|:|||.|.|:|||||.:|:.....|:||||||.||.|.|.|||.:
  Fly   371 FTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLN 435

  Rat   431 DPVLGLVSGQCRCKEHVVGTRCQQCRDGFFGLSASNPRGCQRCQCNSRGTVPGGTPCDSSSGTCF 495
            :...|.|:|.|.||..|.|.||.||:||::.|.:.||.||:.|.||..||: ..:.|...:|.|.
  Fly   436 ELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNSGCVMRTGECK 499

  Rat   496 CKRLVTGDGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEATGQCPCRPHMIGRRCEQVQP 560
            ||:.|||..|::|:|..:|||....||..|:||.||:.|..||..:|||.|||||.||.|.|.:.
  Fly   500 CKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQ 564

  Rat   561 GYFRPFLDHLTWEAE--------GAHGQVLEVVERLVTNRETP--SWTGVGFVRLREGQEVEFLV 615
            .||.|.|..: .|||        ||:|....|.       |||  |:||:||.|:.|..|:.|.|
  Fly   565 NYFIPLLPEV-HEAEVVDECISYGANGNCSLVA-------ETPDGSFTGIGFTRVPENSELVFTV 621

  Rat   616 TSLPRAMDYDLLLRWEPQVPEQWAELELVVQRPGPVSAHSPCGHV---LPRDDRIQGMLHPNTRV 677
            ..:||:|.||.::|::......|....:.:.||..|.....||.:   ...:.||...|...:|.
  Fly   622 GDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQ 686

  Rat   678 LVFPRPVCLEPGLSYKLKLKLTGTGGRAHPETPYSGSGILIDSLVLQPHVLMLEMFSGGDAAALE 742
            :|....||||.|..||.::...    |...:.....:.||:|||.|.|.:.:..:|.|...|.:
  Fly   687 VVALNEVCLEAGKVYKFRIYFE----RKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADI- 746

  Rat   743 RRTTFERYRCHEEGLMPSKTPLSEACVPLLISASSLVYNGALPCQCDPQGSLSSECNPHGGQCRC 807
            |:..:|:|.| :..|..........|..|....|..|::||..|.|:|.||||..|..:||.|:|
  Fly   747 RKKDYEKYNC-KSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQC 810

  Rat   808 KPGVVGRRCDACATGYYGFGPAGCQACQCSPDGALSALCEGTSGQCLCRTGAFGLRCDHCQRGQW 872
            ||.||||:||.||.|.|||||.||:||.|:..|:....|:..:|||.|....:|..|:.||.|.|
  Fly   811 KPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYW 875

  Rat   873 GFPNCRPCVCNGRADECDAHTGACLGCRDYTGGEHCERCIAGFHGDPRLPYGGQ--CRPCPCPEG 935
            .||.||.|.|||.|..||...|.|:.|:|.|.|..|:.|:.|::|:|.  :|.:  ||||.|||.
  Fly   876 NFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPL--FGSEIGCRPCRCPET 938

  Rat   936 PGSQRHFATSCHRDGYSQQIVCHCRAGYTGLRCEACAPGHFGDPSKPGGRCQLCECSGNIDPTDP 1000
            ..|....|..|..|..:..::|||:.||:|.|||.||...||:|.. ||.|..||||.|:|..|.
  Fly   939 VASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDN-GGTCSKCECSNNVDLYDT 1002

  Rat  1001 GACDPHTGQCLRCLHHTEGPHCGHCKPGFHGQAARQSCHRCTCNLLGTDPQRCPSTDLCHCDPST 1065
            |.||..||.||:||:.|.|.||..||.||.|.|.:|:|.:|.|:.|||      :..:.|||..|
  Fly  1003 GNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGT------NNTIAHCDRFT 1061

  Rat  1066 GQCPCLPHVQGLSCDRCAPNFWNFTSGRGCQPCACHPSRARGPTCNEFTGQCHCHAGFGGRTCSE 1130
            |||||||:|||:.||:||.|.|...||.||:.|.|.|..|....||.:||||.|..|||||.|::
  Fly  1062 GQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQ 1126

  Rat  1131 CQELHWGDPGLQCRACDCDPRGIDKPQCHRSTGHCSCRPGVSGVRCDQCARGFSGVFPACHPCHA 1195
            ||..:||:|..:|:.|:||..|....||.|.||:|.|..|:.|.:|::||||:.|.||.|.||..
  Fly  1127 CQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGE 1191

  Rat  1196 CFGDWDRVVQDLAARTRRLEQWAQELQQTGVLGAFESSFLNLQGKLGMVQAIVAARNTSAASTAK 1260
            ||.:||.::..|...|......|:|::|.|..||:.|.|..|..||..::.::...:.|.....|
  Fly  1192 CFNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEK 1256

  Rat  1261 LVEATEGLRHEIGKTTERLTQLEAELTDVQDENFNANHALSGLERDGLALNLTL-RQLDQHLD-- 1322
            |...|:.||.::..:..||::.|..|.|:.:     :.:|||:|.:.|..:..| :||.:.|.
  Fly  1257 LDYETQSLRDQLQASHGRLSETEQNLDDIYN-----SLSLSGVELESLQNHSRLVQQLSKELKEN 1316

  Rat  1323 --ILKHSNFLGAYDSIRHAHSQSTEAERRANASTFAIPSP--VSNSADTRRRAEVLMGAQRENFN 1383
              .|:.||..||.:..|||:      ||.:|.||....:.  .||:....:|.|.|  :.:....
  Fly  1317 GIQLQESNIEGALNLTRHAY------ERVSNLSTLKDEANELASNTDRNCKRVENL--SNKIQAE 1373

  Rat  1384 RQHLANQQAL---GRLSTHTHTLSLTGVNELVCGAPGDAPCATSPCGGAGCRDEDGQPRCGG-LG 1444
            ...|||...|   .|....:.|..:..:|..|||.||| || .|.||||||      ..||| |.
  Fly  1374 ADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGD-PC-DSLCGGAGC------GHCGGFLS 1430

  Rat  1445 CSGAAATADLALGRARHTQAELQRALVEGGGILSR---VSETRRQAEEAQQRAQAALDKANASRG 1506
            |...|.|         |::..|:.|......|.|:   ..:|.|...:|:..|..|.:|  |.||
  Fly  1431 CEHGAKT---------HSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEK--AKRG 1484

  Rat  1507 QVEQANQELRELIQNVK----------DFLSQEGADPDSIEMVATRVLDISIPASPEQIQRLASE 1561
             .||:.:.|.:...|:|          :|...:.|.|...:.:|.:.||:.:...||:|:.|..:
  Fly  1485 -FEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQ 1548

  Rat  1562 IAERVRSLADVDTILAHTMGDVRRAEQLLQDAQRARSRAEGERQKAETVQAALEEAQRAQGAAQG 1626
            |...|.||.:|:.|:..|..|:.|...|...|...:.:|:.....|.:|..:|..|..:||.|:.
  Fly  1549 INRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKD 1613

  Rat  1627 AIRGAVVDTKNTEQTLQQVQERMAGTEQSLNSASERARQLHALLEALKLKRAGNSLAASTAEETA 1691
            ||:.|..:.:...|.|:::.|.....|...|:.:::..:|...::.|:.....|...|....:.|
  Fly  1614 AIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEA 1678

  Rat  1692 GSAQ---SRAREAEKQLREQVGDQYQTVRALAERKAEGVLAAQARAEQLRDEARGLLQAAQDKLQ 1753
            ||.:   .|||.....|:.......||:...|.|...    |:.||:||...|..|......||:
  Fly  1679 GSVKLEAMRARGEANNLQSATSATNQTLTDRASRSEN----ARERAKQLLQRASKLTVDTNAKLK 1739

  Rat  1754 RLQELEGTYEENERELEVKAAQLDGLEARMRSVLQAINLQVQIYNTC 1800
            .|.:|:..|....::|....|::..|...:...|..|..:...|..|
  Fly  1740 DLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lamb2	NP_037106.1	Laminin_N	60..284	CDD:278484	134/224 (60%)
		EGF_Lam	286..338	CDD:238012	33/54 (61%)
		EGF_Lam	350..402	CDD:238012	37/51 (73%)
		Laminin_EGF	413..470	CDD:278482	29/56 (52%)
		EGF_Lam	472..523	CDD:238012	20/50 (40%)
		EGF_Lam	524..565	CDD:238012	22/40 (55%)
		EGF_Lam	786..831	CDD:214543	28/44 (64%)
		Laminin_EGF	834..882	CDD:278482	19/47 (40%)
		Laminin_EGF	880..927	CDD:278482	19/48 (40%)
		EGF_Lam	929..987	CDD:238012	25/57 (44%)
		Laminin_EGF	989..>1031	CDD:278482	24/41 (59%)
		Laminin_EGF	1041..1095	CDD:278482	27/53 (51%)
		Laminin_EGF	1098..1146	CDD:278482	23/47 (49%)
		Laminin_EGF	1146..>1185	CDD:278482	18/38 (47%)
		Domain II	1193..1412		63/228 (28%)
		Domain alpha	1413..1445		18/32 (56%)
		Domain I	1446..1801		92/371 (25%)
		DUF4398	<1446..1516	CDD:291044	18/72 (25%)
		flagell_FliJ	1477..1617	CDD:131526	40/152 (26%)
		HrpJ	1485..1673	CDD:301626	51/197 (26%)
		MscS_porin	1582..1776	CDD:289559	49/196 (25%)
		ATP-synt_B	<1684..1795	CDD:304375	29/113 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1684..1703		7/21 (33%)
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484	134/225 (60%)
		EGF_Lam	287..343	CDD:238012	33/55 (60%)
		Laminin_EGF	355..415	CDD:278482	38/59 (64%)
		Laminin_EGF	418..475	CDD:278482	29/56 (52%)
		EGF_Lam	477..526	CDD:238012	19/49 (39%)
		EGF_Lam	529..567	CDD:214543	20/37 (54%)
		EGF_Lam	789..834	CDD:214543	28/44 (64%)
		Laminin_EGF	837..885	CDD:278482	19/47 (40%)
		Laminin_EGF	883..930	CDD:278482	19/48 (40%)
		Laminin_EGF	933..988	CDD:278482	24/55 (44%)
		Laminin_EGF	991..1043	CDD:278482	28/51 (55%)
		Laminin_EGF	1043..1091	CDD:278482	27/53 (51%)
		Laminin_EGF	1094..1142	CDD:278482	23/47 (49%)
		Laminin_EGF	1142..1190	CDD:278482	23/47 (49%)
		COG6	1212..>1398	CDD:303003	55/198 (28%)
		TelA	1439..1782	CDD:226371	87/349 (25%)
		ApoLp-III_like	1545..1702	CDD:304399	39/156 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1319
eggNOG	1	0.900	-	-		E1_KOG0994
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1723
Inparanoid	1	1.050	1462	1.000	Inparanoid score	I103
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D42471at33208
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		otm45315
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880