DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcna5 and Shab

DIOPT Version :9

Sequence 1:	NP_037104.1	Gene:	Kcna5 / 25470	RGDID:	2953	Length:	602	Species:	Rattus norvegicus
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	644	Identity:	195/644 - (30%)
Similarity:	300/644 - (46%)	Gaps:	168/644 - (26%)

- Green bases have known domain annotations that are detailed below.

  Rat    18 GGGEAGASC------VQTPRGECGCPPTS----------GLNNQSKETLLRGRTTLEDANQGG-- 64
            |.|.||...      |.:|..  ..|.||          |:...|.:::..|..|...:|..|
  Fly   218 GSGAAGKEVRYAPFPVASPTH--SIPTTSQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGAL 280

  Rat    65 --------RPLPPMAQELPQPRRLSAEDEEGEGDPGLGTVEEDQAPQDAGSLHHQRVLINISGLR 121
                    ..:||     |:|..::                :.:|.       :.||.||:.|:|
  Fly   281 QRTHSRSMSSIPP-----PEPFMIA----------------QSKAV-------NSRVSINVGGVR 317

  Rat   122 FETQLGTLAQFPNTLLGDPAKRLHY-------------FDPLRNEYFFDRNRPSFDGILYYYQSG 173
            .|....||.:.|:|.||    ||..             :....|||||||:..||..||.:|::
  Fly   318 HEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT- 377

  Rat   174 GRLRRPVNVSLDVFADEI----------------RFYQLGDEAMERFR-EDEGFIKEEEKPLPRN 221
            |:|.....:.:..|:|::                :::|..:...|..| |.|...:.:|:.....
  Fly   378 GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEG 442

  Rat   222 ---EFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPP 283
               |:|:.:|.:.|.|.:|.:||.||::|:|.|::|.|...|.|||:       |:|..
  Fly   443 KCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQ-------LQHID------ 494

  Rat   284 APAPGINGSVSGALSSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIM 348
                      :|.....|.:|            :||..|:.|||.|.::||.|.|.|.:|.:..:
  Fly   495 ----------NGTPQDNPQLA------------MVEAVCITWFTLEYILRFSASPDKWKFFKGGL 537

  Rat   349 NIIDVVAIFPYFITLGTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG 413
            ||||::||.|||::|......:......|:.::     :::|.|::|:.||.||:|||.|||.||
  Fly   538 NIIDLLAILPYFVSLFLLETNKNATDQFQDVRR-----VVQVFRIMRILRILKLARHSTGLQSLG 597

  Rat   414 KTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNHGSHFSSIPDAFWWAVVTMTTVGYGDMRPI 478
            .||:.|.:|||||:.||.:||::|||..||||.|...:.|.|||:.||||.:|||||||||:.|.
  Fly   598 FTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPT 662

  Rat   479 TVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGNQRRESGLDTGGQR 543
            |..||::|::|.|.|||.||||:|:||:||..||..:        ::.|:..:|||: ||.
  Fly   663 TALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQ--------MRREKALKRREA-LDR---- 714

  Rat   544 KVSCSKASFCKTGGSLESSDSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRETDL 602
                     .|..||:.|...|.     |:....|:...:|       :.:||.::|::
  Fly   715 ---------AKREGSIVSFHHIN-----LKDAFAKSMDLID-------VIVDTGKQTNV 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcna5	NP_037104.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..107		7/58 (12%)
		BTB	113..207	CDD:197585	33/123 (27%)
		BTB_2	113..204	CDD:280393	32/119 (27%)
		Ion_trans	305..515	CDD:278921	97/209 (46%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	407..420		7/12 (58%)
		Ion_trans_2	429..506	CDD:285168	45/76 (59%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	469..474		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..543		6/19 (32%)
		PDZ-binding	600..602		1/1 (100%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585	30/111 (27%)
		BTB_2	309..408	CDD:280393	30/103 (29%)
		Ion_trans	501..700	CDD:278921	99/223 (44%)
		Ion_trans_2	613..696	CDD:285168	48/82 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810