DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcna4 and Shawl

DIOPT Version :9

Sequence 1:	NP_037103.2	Gene:	Kcna4 / 25469	RGDID:	2952	Length:	654	Species:	Rattus norvegicus
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	178/525 - (33%)
Similarity:	249/525 - (47%)	Gaps:	147/525 - (28%)

- Green bases have known domain annotations that are detailed below.

  Rat   178 RVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 242
            |:::||||:|:||...||.:.|.|.|....:....:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

  Rat   243 KRPVNVPFDIFTEEVKFYQLGEE--------------------ALLKFREDEGFVREEE------ 281
            ..|.:|...:|.||::|:.|...                    |:|...:.|.....||
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

  Rat   282 --DRALPENE------FKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRD 338
              :.||...|      .|.:||.:|:.|.||:.|:.:|.:||..|.:|::.|||:|.|.||.|
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVD-- 197

  Rat   339 LIMALSAGGHS-----------------------------------------RLLNDT--SAPHL 360
                |.:|.|.                                         |:.|.|  |:.:.
  Fly   198 ----LPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNF 258

  Rat   361 ENSGH---------------------TIFN--------------------------DPFFIVETV 378
            ..||.                     :|.|                          :.||.||.|
  Fly   259 TASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELV 323

  Rat   379 CIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAI 443
            |.|||..|.::|....|:...|.|:.:||||..:.|.::    ||:.|:.|...|         :
  Fly   324 CNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYTG---------L 375

  Rat   444 LRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAE--ADEPT 506
            |....:||:.|:|||:|||.||:||.||.:||.:||.||:|||.:|::.|:|..|:||  .|.|.
  Fly   376 LEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPD 440

  Rat   507 THFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HR 570
            ..|:|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||||||:.|| |.
  Fly   441 NQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHT 505

  Rat   571 ETENE 575
            :..::
  Fly   506 QARSK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcna4	NP_037103.2	K_channel_TID	1..>37	CDD:400339
		BTB_POZ	177..304	CDD:365784	49/159 (31%)
		Ion_trans	307..571	CDD:395416	127/356 (36%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	463..476		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	525..530		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..654
		PDZ-binding	652..654
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	35/92 (38%)
		BTB_2	7..97	CDD:280393	35/90 (39%)
		Ion_trans	307..506	CDD:278921	102/211 (48%)
		Ion_trans_2	<449..499	CDD:285168	37/49 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810