DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Il1rap and Dscam2

DIOPT Version :9

Sequence 1:	XP_038943965.1	Gene:	Il1rap / 25466	RGDID:	2893	Length:	697	Species:	Rattus norvegicus
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	661	Identity:	127/661 - (19%)
Similarity:	215/661 - (32%)	Gaps:	242/661 - (36%)

- Green bases have known domain annotations that are detailed below.

  Rat     2 LQKFLVTGCPSSL--ESHLGLQYKGSV-RLAHFPSERCDDWGLDTMRQIQVFEDEPARIKC---- 59
            |.:.:|...|:.|  .||.|:.....| ..||                :||.:||.|.:.|
  Fly   215 LTRQVVVSSPTRLRINSHRGIISPSVVEHTAH----------------VQVSQDEGAVLLCVAQG 263

  Rat    60 ---PLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDT 121
               |      :|::.|.:.:|                |:.. |...|:.....:|........|:
  Fly   264 CPSP------EYSWFTHNGAG----------------PLPV-LSGPRVRLLGPILAIEAVTGEDS 305

  Rat   122 GNYTCM-----------LRNTTYCSKVAFPLEVVQKDSCFNSPMRLPVHRLYIEQGIHNITCPNV 175
            |.|.|.           ||.|     ||.|::|.      .||..|.||.    .|.....|...
  Fly   306 GVYKCTAGNVGGEASAELRLT-----VATPIQVE------ISPNVLSVHM----GGTAEFRCLVT 355

  Rat   176 DGYFPSSVKPSVTWYKGCTEIVNFHNVQPKGMNLSFFIPLVS--NNGNYTCVVTYLENGRLFHLT 238
            ....|..:: ::.|||...::.:...|:.     :..:|.||  |.|.|.|||...| |..|..|
  Fly   356 SNGSPVGMQ-NILWYKDGRQLPSSGRVED-----TLVVPRVSRENRGMYQCVVRRPE-GDTFQAT 413

  Rat   239 RTMTVKVVGSPKDAVPPHIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEIWWTIDG-KKPD 302
            ..:.:      .||.|..:||..::.:   :||..:.:.|    |...:...:|.||:|| ..|.
  Fly   414 AELQL------GDAPPVLLYSFIEQTL---QPGPAVSLKC----SAAGNPTPQISWTLDGFPLPS 465

  Rat   303 D----------VPVDITINESVSYSSTED--------ETRT---------------QILSIKKVT 334
            :          |..|:..:.::|:...||        |.|.               .|..|.|||
  Fly   466 NGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLIPKVT 530

  Rat   335 ------------------------------PEDLKRN--------------------YVCHARNA 349
                                          |:|:::.                    |.|.|||.
  Fly   531 AVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNK 595

  Rat   350 EGEAEQAAKVKQKVIPPRYT------VELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTD 408
            :|.:.:.:.....::||:.:      ::|..|..|::...||      ...|.:.:.:|.
  Fly   596 QGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVV------KGDLPLTINWRK----- 649

  Rat   409 ETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRS 473
                ||:..|.....:....::...:|.:..:..:..|...|:....:..           ::.|
  Fly   650 ----DGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAE-----------VENS 699

  Rat   474 RRMIVVLSPDYVTEKSISMLEFKLGVM--CQNSIATKLIVVEYRPLEQPHPGIMQLKESVSFVSW 536
            :.::|.:.|.::.|...:.:|....:|  ||..             ..|.|.|:          |
  Fly   700 QALLVNVPPRWIVEPVDANVERNRHIMLHCQAQ-------------GVPTPSIV----------W 741

  Rat   537 KGEKSKHSGSK 547
            |    |.:|||
  Fly   742 K----KATGSK 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Il1rap	XP_038943965.1	Ig1_IL1R_like	37..144	CDD:409584	24/124 (19%)
		Ig strand B	55..59	CDD:409584	1/3 (33%)
		Ig strand C	79..83	CDD:409584	0/3 (0%)
		Ig strand E	109..113	CDD:409584	1/3 (33%)
		Ig strand F	123..128	CDD:409584	2/15 (13%)
		Ig strand G	136..139	CDD:409584	1/2 (50%)
		Ig	155..247	CDD:416386	23/93 (25%)
		Ig strand A	157..162	CDD:409353	2/4 (50%)
		Ig strand A	157..162	CDD:409353	2/4 (50%)
		Ig strand B	168..172	CDD:409353	0/3 (0%)
		Ig strand B	168..172	CDD:409353	0/3 (0%)
		Ig strand C	186..191	CDD:409353	1/4 (25%)
		Ig strand C	186..191	CDD:409353	1/4 (25%)
		Ig strand C'	194..196	CDD:409353	0/1 (0%)
		Ig strand C'	194..196	CDD:409353	0/1 (0%)
		Ig strand D	201..205	CDD:409353	1/3 (33%)
		Ig strand D	201..205	CDD:409353	1/3 (33%)
		Ig strand E	207..212	CDD:409353	0/4 (0%)
		Ig strand E	207..212	CDD:409353	0/4 (0%)
		Ig strand F	221..230	CDD:409353	4/8 (50%)
		Ig strand F	221..230	CDD:409353	4/8 (50%)
		Ig strand G	233..246	CDD:409353	2/12 (17%)
		Ig strand G	233..246	CDD:409353	2/12 (17%)
		Ig3_IL1RAP	255..361	CDD:409525	32/189 (17%)
		Ig strand B	274..278	CDD:409525	0/3 (0%)
		Ig strand C	291..295	CDD:409525	1/3 (33%)
		Ig strand E	326..330	CDD:409525	1/3 (33%)
		Ig strand F	341..346	CDD:409525	2/24 (8%)
		Ig strand G	353..356	CDD:409525	0/2 (0%)
		TIR	416..559	CDD:214587	21/134 (16%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	24/132 (18%)
		Ig	247..327	CDD:299845	21/107 (20%)
		I-set	332..418	CDD:254352	26/102 (25%)
		IGc2	344..407	CDD:197706	17/73 (23%)
		IG_like	432..517	CDD:214653	17/91 (19%)
		IGc2	436..507	CDD:197706	17/74 (23%)
		I-set	521..610	CDD:254352	13/88 (15%)
		IGc2	533..597	CDD:197706	7/63 (11%)
		Ig	630..699	CDD:143165	11/94 (12%)
		IG_like	714..802	CDD:214653	13/62 (21%)
		Ig	725..802	CDD:299845	12/51 (24%)
		Ig	823..894	CDD:143165
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910