DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fshr and rk

DIOPT Version :9

Sequence 1:	NP_954707.1	Gene:	Fshr / 25449	RGDID:	2632	Length:	692	Species:	Rattus norvegicus
Sequence 2:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster

Alignment Length:	904	Identity:	249/904 - (27%)
Similarity:	371/904 - (41%)	Gaps:	290/904 - (32%)

- Green bases have known domain annotations that are detailed below.

  Rat    18 CHHWL---CHCSNRV----FLCQDSKVTEIPTDLPRNAIELRF---VLTK--------------- 57
            |..||   |||:..:    ..|:...:..:|.:||...:.|..   .|||
  Fly   144 CERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEEL 208

  Rat    58 ------------------------------LRVIPKGSFAGFGDLEKIEISQNDVLEVIEADVFS 92
                                          |:.:|..||.|...|..::::.| .|..::.|...
  Fly   209 TLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGN-ALVSLDGDCLG 272

  Rat    93 NLPKLHEIRIEKANNLLY-------------------------INPEAFQNLPSLRYLL------ 126
            :|.||..:|:|  .||.|                         ||.|.|..:|:|..||
  Fly   273 HLQKLRTLRLE--GNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQI 335

  Rat   127 --ISNTGIKHLPA-----------------VHKIQSLQKV--------------------LLDIQ 152
              ||...:|:|.|                 :.|:..||::                    :||::
  Fly   336 MKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMR 400

  Rat   153 DNINIHIVARNSFMGLS------------------------------------------------ 169
            .| .:..::..:|.|:|
  Fly   401 AN-PLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPR 464

  Rat   170 FESV--------------------ILWLSKNGIEEIHNCAFNG-TQLDELNLSDNNNLEELPNDV 213
            .:|:                    :|.||.|.||:|....||| .||::|.|| .|.::.||.|.
  Fly   465 LKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLS-YNRIKALPQDA 528

  Rat   214 FQGASGPVILDISRTKVH------------------------SLPNHGLENLKKLRARSTYRLKK 254
            |||.....:||:...::.                        .||..||..|..|:..:..:|::
  Fly   529 FQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLRE 593

  Rat   255 LPNLDKFVTLMEASLTYPSHCCAFA---------------------------------------- 279
            .|..|.|..:....|:|..|||||.
  Fly   594 FPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWP 658

  Rat   280 ---NLKRQI-SELHPICNKSILRQDIDDMTQIGDQRVSLIDDE---------PSYGKG------S 325
               ||.:|: :.:|.....:|...:....||.|.|..:...:|         |:.|.|      |
  Fly   659 QMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFS 723

  Rat   326 DMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQ 390
            .|...:|      :...|.|.|.|..|.||.|:..:..||..:|.:.:|::.||.||:.||..|:
  Fly   724 GMSTEDF------QPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSR 782

  Rat   391 YKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELS 455
            .|:.|||||:||||.||..:||||.::|.||..|..::..:||.||....|..:||..|.:||||
  Fly   783 SKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELS 847

  Rat   456 VYTLTAITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSYMKVSICLPMD 520
            ||||..|||||.:.||||:.|..::.|:.|..:|.:||.||...||.|:.|:|.|.|.::|||.:
  Fly   848 VYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFE 912

  Rat   521 IDS-PLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNPTIVSSSSDTKIAKRMATLIFTDFLCM 584
            ..: |.|..||::|:.:|..||:.:.|||..:|..:|. :...:::|::||||||.|:||||||.
  Fly   913 TTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRG-SQAWNTNDSRIAKRMALLVFTDFLCW 976

  Rat   585 APISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKF 643
            :||:||:|:|...:.||::.:|||..|...|:|||.|||||||.||.|::|...|...|
  Fly   977 SPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHF 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fshr	NP_954707.1	LRRNT	23..50	CDD:214470	7/30 (23%)
		LRR 1	49..72		9/70 (13%)
		LRR_8	72..132	CDD:290566	22/92 (24%)
		leucine-rich repeat	72..96	CDD:275380	5/23 (22%)
		LRR 2	73..97		4/23 (17%)
		leucine-rich repeat	97..121	CDD:275380	10/48 (21%)
		LRR 3	98..118		9/44 (20%)
		LRR 4	119..143		10/48 (21%)
		leucine-rich repeat	122..143	CDD:275380	9/45 (20%)
		leucine-rich repeat	144..171	CDD:275380	8/94 (9%)
		LRR 5	144..169		7/44 (16%)
		LRR 6	170..192		9/41 (22%)
		leucine-rich repeat	172..194	CDD:275380	11/42 (26%)
		LRR_8	193..245	CDD:290566	19/75 (25%)
		LRR 7	193..216		10/22 (45%)
		leucine-rich repeat	195..219	CDD:275380	11/23 (48%)
		LRR 8	217..240		6/46 (13%)
		leucine-rich repeat	220..243	CDD:275380	7/46 (15%)
		LRR 9	241..259		4/17 (24%)
		GnHR_trans	282..348	CDD:289164	16/81 (20%)
		7tm_1	378..625	CDD:278431	116/247 (47%)
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/20 (15%)
		LRR_RI	180..>383	CDD:238064	37/205 (18%)
		leucine-rich repeat	183..204	CDD:275380	4/20 (20%)
		LRR_8	203..263	CDD:290566	7/60 (12%)
		leucine-rich repeat	205..228	CDD:275380	0/22 (0%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	12/61 (20%)
		leucine-rich repeat	253..276	CDD:275380	5/23 (22%)
		leucine-rich repeat	277..300	CDD:275380	6/24 (25%)
		LRR_8	299..359	CDD:290566	13/59 (22%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	41/241 (17%)
		leucine-rich repeat	349..371	CDD:275380	1/21 (5%)
		LRR_8	370..425	CDD:290566	8/55 (15%)
		leucine-rich repeat	372..393	CDD:275380	2/20 (10%)
		leucine-rich repeat	394..415	CDD:275380	4/21 (19%)
		leucine-rich repeat	418..486	CDD:275380	1/67 (1%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	24/58 (41%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	11/23 (48%)
		LRR_8	533..589	CDD:290566	8/55 (15%)
		leucine-rich repeat	535..558	CDD:275380	2/22 (9%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tm_4	764..>892	CDD:304433	61/127 (48%)
		7tm_1	770..1017	CDD:278431	116/247 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810