DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fosl1 and Atf3

DIOPT Version :9

Sequence 1:	NP_037085.1	Gene:	Fosl1 / 25445	RGDID:	2627	Length:	275	Species:	Rattus norvegicus
Sequence 2:	NP_001259125.1	Gene:	Atf3 / 43867	FlyBaseID:	FBgn0028550	Length:	688	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	78/358 - (21%)
Similarity:	135/358 - (37%)	Gaps:	131/358 - (36%)

- Green bases have known domain annotations that are detailed below.

  Rat    11 SSGAGSAYGRPAQPQQAQTQTVQQ--------------QKFHLVPSINAVSGSQELQWMVQPH-- 59
            ||.:||....||  ..|.|.:|||              |....:.:.::.|||:      |||
  Fly    95 SSCSGSPLDSPA--GTATTPSVQQTCSRLIKEGLKLSIQSKRKLSTCDSSSGSE------QPHSK 151

  Rat    60 -------FLGPSGYPRPLTYPQYSPPQPRPGVI------------RALGPPPGVRRRPCEQISPE 105
                   ..|.||     :...||........:            .....|.|        ::||
  Fly   152 YSRRSSNHNGHSG-----SSNNYSGSMSNANDLDDDCEESSDDDSETKSQPKG--------LTPE 203

  Rat   106 EEERRRVRRERNKLAAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQKERLELVLEAH 170
            :|:|||.||||||:||.|||.:::|.|..|..|::.|:.:...|:.::.:|:.::::|..:|::|
  Fly   204 DEDRRRRRRERNKIAATKCRMKKRERTQNLIKESEVLDTQNVELKNQVRQLETERQKLVDMLKSH 268

  Rat   171 ----RPICKIPEE--------------------DKKDTGGT----------------SSTSGAGS 195
                ...|::|.:                    |..::|..                |.|:.|.:
  Fly   269 GCQRAGGCQLPSQLLQSPAQKYLSELELETVSIDGPNSGNNNQRLQSIPSMATFKYGSKTAAAMA 333

  Rat   196 ---PPGPCRPVPCI---------------------SLSP---GPVLEPEALHTPTLMT--TPSLT 231
               |.|.|:|.|..                     ||:|   ..:.:..|..:|:|::  .|:..
  Fly   334 QQLPNGYCKPSPSAQEFEHAGYQQQQQQQQQQQPQSLNPAGNNVIDQQHANPSPSLLSDYVPNCD 398

  Rat   232 PFTPSLVFTYPSTPEPCSSAHRKSSSSSGDPSS 264
            ..|.|      ::..|..:.:..:::|||..|:
  Fly   399 GLTGS------ASNHPSHNNNNNNNNSSGASSN 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fosl1	NP_037085.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..115		11/55 (20%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	109..129		14/19 (74%)
		bZIP_Fos	117..170	CDD:269869	16/52 (31%)
		coiled coil	117..161	CDD:269869	14/43 (33%)
		VirB10_like	128..>247	CDD:421703	31/187 (17%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	135..163		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..275		26/159 (16%)
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	16/52 (31%)
Atf3	NP_001259125.1	coiled coil	215..265	CDD:269870	15/49 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336961
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740