DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fosl1 and kay

DIOPT Version :9

Sequence 1:NP_037085.1 Gene:Fosl1 / 25445 RGDID:2627 Length:275 Species:Rattus norvegicus
Sequence 2:NP_001027577.2 Gene:kay / 3772082 FlyBaseID:FBgn0001297 Length:755 Species:Drosophila melanogaster


Alignment Length:266 Identity:69/266 - (25%)
Similarity:100/266 - (37%) Gaps:91/266 - (34%)


- Green bases have known domain annotations that are detailed below.


  Rat    93 GVRRRP--CEQISPEEEERRRVRRERNKLAAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEE 155
            |..|||  ...::||||::|.|||||||.|||:||.||.:.|:.|..|.::||.....:::|||.
  Fly   402 GGGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEV 466

  Rat   156 LQKQKERLELVLEAHRPICKIPEED----------------------------------KKDTGG 186
            |...|.:||.:|..||..|:....|                                  ...:.|
  Fly   467 LTNSKNQLEYLLATHRATCQKIRSDMLSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNG 531

  Rat   187 T--------SSTSGAGSP-----------------------------------PGPCRPVPCISL 208
            |        :||..:.||                                   |.|.:.:....:
  Fly   532 TITGMDATLNSTGRSNSPLDLKPAANIDSLLMHIKDEPLDGAIDSGSSLDQDGPPPSKRITLPPM 596

  Rat   209 SPGPVLEPEALHTPTLMTTPSL-TPFTPSLVFTYPSTPEPCSSAHRKSSSSSGDPSSDPLG---- 268
            |..|.:....:.|||..::.|| ||.|       .:.|....||...:|:.|...:.:.:|    
  Fly   597 STMPHVHLSTILTPTGASSGSLQTPIT-------STAPGGFGSAFPVTSNGSSINNINSIGNNMN 654

  Rat   269 SPTLLA 274
            ||||.|
  Fly   655 SPTLNA 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fosl1NP_037085.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 71..115 11/23 (48%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 109..129 14/19 (74%)
bZIP_Fos 117..170 CDD:269869 22/52 (42%)
coiled coil 117..161 CDD:269869 18/43 (42%)
VirB10_like 128..>247 CDD:421703 37/196 (19%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 135..163 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 171..275 32/186 (17%)
kayNP_001027577.2 bZIP_Fos 420..481 CDD:269869 28/60 (47%)
coiled coil 421..480 CDD:269869 28/58 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1414
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002314
OrthoInspector 1 1.000 - - otm46432
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23351
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
65.960

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