DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pex6 and Pex6

DIOPT Version :9

Sequence 1:	NP_593468.1	Gene:	pex6 / 2542437	PomBaseID:	SPAC17A5.01	Length:	948	Species:	Schizosaccharomyces pombe
Sequence 2:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	1007	Identity:	288/1007 - (28%)
Similarity:	460/1007 - (45%)	Gaps:	239/1007 - (23%)

- Green bases have known domain annotations that are detailed below.

pombe    19 KQAWVSYLWLKKALPGFEEHSAY---------VYMTTNPTIAGRIF-LPINNEDLEDGTVEISGY 73
            |..|..|       ||:..::.|         .::.|  .|..|:: |.|.||.::...:..:..
  Fly    54 KWPWFLY-------PGYLTYAVYWRYAKYYKGKFLLT--PIPNRLYDLLIKNEQIKSEHLVFASQ 109

pombe    74 DNLLADALYISTIAPVKLDFVQLIVIDDNSQDQDAIIERIKGRNAILMESDFINQNILVQVCQPV 138
            :      :|.:......::||.|:               |:||.              |::.:|
  Fly   110 E------VYENYAESPDVNFVNLV---------------IRGRR--------------VRIGKP- 138

pombe   139 RHGVVDSETKFVIERKDSFTFLASNEKNISSFKRGKTETDAELVIR--PSKVHTEI---QWCLQN 198
                                 |||:|.|:       |:|..:.:::  |..:..:|   ..|..|
  Fly   139 ---------------------LASDEGNM-------TQTVIKQMLQEAPHTIVAQILPAAQCQPN 175

pombe   199 CSLIHVPF--ELLFNVGKKNGCPISL-RLSDGKNVYGIASIKSDTEHDSVQLSPSLHYFD-EFNE 259
            |..:...|  .:|.....::.|.:.: ..:|.:.:.|||:    ..|  |.|....|... |..|
  Fly   176 CLYVQENFYGNILDRFQIRSNCWVQVEHFADEQTIPGIAT----KAH--VYLVADPHELPAELTE 234

pombe   260 SVISEEGTEAFLVARGPSVGIASRISLRTIPTQSCFSEKLLKAANLCVVQQVKQKVFLQSKQIFC 324
            .::|.......|:.||.:..|  .::...:.|.:.....|:.|             .|:...:.|
  Fly   235 VILSNYFNTPRLMHRGHTYRI--EVNAELVGTATYAHYYLIFA-------------HLRHVHLKC 284

pombe   325 VPINSLMANSDSVDILELTRNTDAYIWYSVEEIDPLNTYNIYYTNEDTSI----VLDTQLSHRLL 385
            :.:.              |:.::    :.::.|...|..|:.......|.    |||:.......
  Fly   285 IHLE--------------TKGSE----FELQAIVAKNFSNLVQVPASHSFLPRQVLDSMAIVENY 331

pombe   386 PS-LRKPLLNFVKVHPPSQKLLRFCRAFFDPQQVPGFN-----PFFLLHGNPFTGKTKAVEEVAS 444
            || ||||           .||||.....|.|::....:     |.|||.|...:||:|.|..||.
  Fly   332 PSGLRKP-----------YKLLRSSVDAFLPKKSACLSSKHIFPVFLLQGERGSGKSKLVSAVAQ 385

pombe   445 LFSAPVFTISSYEFADATADHLEAKLD-MFVQNVVKSPCAIIF------------VKDLDVLS-- 494
            .....::.....|.......|.|.||. :|.::.|..|..|.|            .:||.:||
  Fly   386 ELGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFEIFGIDNEGNEDLRLLSAF 450

pombe   495 --------------------ISSDEGNIVPGSKSIQILLSKIDLVKSPQGRYIVIGTCHSIEKIP 539
                                ::||. ::.|..:.:.:.:..||: .|.:.|:.::...|
  Fly   451 HVQVQELFNRDRKHPIVVVALTSDR-HLKPMIQGLFLEIINIDM-PSKEERFEILRWMH------ 507

pombe   540 YEILSESFFELKFSELEMDERLELLKIYA--NNVIIDKRIS---------LKDVALKTNSMSFGE 593
               :.|:|.::.:::    :.:|.|.:::  |......|||         |:|||.|:.....|:
  Fly   508 ---VRETFNDIIYNQ----KAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVAAKSQGFLLGD 565

pombe   594 LECLPDHMTKAAV-DRIKRTGYDNDSIILSGPIITEQDVDVSINRIRKEKSNTIFTVPKVNWDDI 657
            |:.|.|:..:..: :|:.||..|......:   :|:.....: :.:...|      ||||.|.||
  Fly   566 LQLLYDNAVRMKIRNRLGRTTLDMSHFAKN---LTDMQSSFA-DSLGAPK------VPKVYWSDI 620

pombe   658 GGLEEAKTVLRDTLQLPLQFPELFSQGLKPRSGVLLYGPPGTGKTLLAKAVATELSLEFVSIKGP 722
            |||.:.|..::.::.|||:...|..:.|: |||:||||||||||||:|||||||.:|.|:|::||
  Fly   621 GGLAKLKDEIQSSIGLPLKHVHLMGKNLR-RSGILLYGPPGTGKTLVAKAVATECNLSFLSVQGP 684

pombe   723 ELLNMYVGESEANVRNVFEKARNSSPCVIFFDELDSIAPHRGNSSDSGNVMDRVVSQLLAELDSI 787
            ||||||||:||.|||.||.:||:::|||:|.|||||:||:||.:.|||.||||||||||||:|.:
  Fly   685 ELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVAGDSGGVMDRVVSQLLAEMDGM 749

pombe   788 SK-DNNKYVFVIGATNRPDLLDPSLLRPGRFDKLVYLGINKSEESKASMLRALTKTFKLDETIDL 851
            |. |.:|.:|::.|||||||:||:||||||||||.|:|...:.|.||::|||.|:.|.||..:|:
  Fly   750 SDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAEDKAAVLRAQTQRFALDAGVDM 814

pombe   852 NEIAKNCHPNFTGADMYALCSDAVLSAIKRKTNEIDLLIQASGTDLSTEEFFKRNENQDSLELRI 916
            .:||:......:|||:|::||:|.|||::|..:.     ..||| :|.:|....|       :.:
  Fly   815 EQIAERLKSEMSGADLYSICSNAWLSAVRRTIDG-----HLSGT-ISEKELVPEN-------VIV 866

pombe   917 TKEDFLTSLKKLRPSISEQELHRYEMVRHQFS 948
            .:|||..|..|..||||.::|..:..::..:|
  Fly   867 QEEDFTKSFNKFVPSISAKDLEYFNNLKASYS 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pex6	NP_593468.1	SpoVK	426..937	CDD:223540	207/558 (37%)
		AAA	426..544	CDD:278434	31/152 (20%)
		P-loop_NTPase	646..>719	CDD:304359	40/72 (56%)
		AAA	691..824	CDD:278434	94/133 (71%)
		Vps4_C	<912..941	CDD:286426	10/28 (36%)
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	192/505 (38%)
		P-loop_NTPase	367..492	CDD:304359	26/125 (21%)
		AAA	653..787	CDD:278434	94/133 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	199	1.000	Domainoid score	I667
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I566
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004626
OrthoInspector	1	1.000	-	-		oto101190
orthoMCL	1	0.900	-	-		OOG6_103617
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R903
SonicParanoid	1	1.000	-	-		X3235
TreeFam	0	0.000	Not matched by this tool.
	10	9.990