Protein Alignment Ctse and Bace

DIOPT Version :9

• Sequence 1: XP_006249810.1
• Gene: Ctse / 25424
• RGDID: 2446
• Length: 398
• Species: Rattus norvegicus
• Sequence 2: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Alignment Length: 391
• Identity: 176/391 - (45%)
• Similarity: 240/391 - (61%)
• Gaps: 27/391 - (6%)

  Rat     7 LLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCNVDKGINEP 71
            :.:::||..||.|:  |||||:.:.|:..|  ..|..|::  :|:.....:.....:||:   |.
  Fly     5 IAVVVLLAALASAE--LHRVPILKEQNFVK--TRQNVLAE--KSYLRTKYQLPSLRSVDE---EQ 60

  Rat    72 LINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSSTYMEVGNH 136
            |.|.::|.|:|.:|||:|:|:|.|:||:|||||||||..|.|.||..|..:..|.||||:..|..
  Fly    61 LSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGES 125

  Rat   137 FSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTP 201
            ||||||||||||.:..|.|.|.||:::.|.|.||..|||..|.:|.||||||:.|.||||.||.|
  Fly   126 FSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAP 190

  Rat   202 VFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQGYWQIALDGIQ 266
            .|.||::|.||...:||.||:.|.....|.||.|||.|.|.:||:|.::|:::|||||..:.|..
  Fly   191 PFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSS 255

  Rat   267 VGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEYAVDCATLNMMPNVTFLING 331
            : |....|.: ||||.|||||||..|......|.|.:.... ||  .:||::::.:|:|||.|.|
  Fly   256 I-DGYSLCDD-CQAIADTGTSLIVAPYNAYITLSEILNVGE-DG--YLDCSSVSSLPDVTFNIGG 315

  Rat   332 VSYTLSPTAYILPDLVDGMQFCGSGFQ--GLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVGLA 394
            .::.|.|:|||:..  ||.  |.|.|:  |.|       .||||||||.::|:.||.|||::|.|
  Fly   316 TNFVLKPSAYIIQS--DGN--CMSAFEYMGTD-------FWILGDVFIGQYYTEFDLGNNRIGFA 369

  Rat   395 P 395
            |
  Fly   370 P 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctse	XP_006249810.1	A1_Propeptide	23..51	CDD:285240	9/27 (33%)
		Asp	79..396	CDD:278455	155/319 (49%)
		pepsin_retropepsin_like	80..395	CDD:299705	153/316 (48%)
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	157/325 (48%)
		Asp	68..371	CDD:278455	155/319 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm45782
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860