DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vps41 and lt

DIOPT Version :9

Sequence 1:	NP_593409.2	Gene:	vps41 / 2542058	PomBaseID:	SPAP27G11.05c	Length:	871	Species:	Schizosaccharomyces pombe
Sequence 2:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	801	Identity:	221/801 - (27%)
Similarity:	377/801 - (47%)	Gaps:	83/801 - (10%)

- Green bases have known domain annotations that are detailed below.

pombe     9 DSEIDSISSSDEDEEPKLIYERITEKFQGCFMNDTISACAISKEHFFFGSHNGAIYIYQKNG--- 70
            ||..|||  ::||.|||..|.|:....:.....|.|:..|:..:...||:..|.:.|:...|
  Fly    11 DSWADSI--NEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSV 73

pombe    71 ---ILLRKMILHSASVVDLSVDLESENLASCSMDGKMIISNITTRETTVH--DFKRPLLSVAIDP 130
               :...:...|..:|.::.||.:.|.:|:||.|||:.|:.:.:.:.. |  .|.:.:..|:::|
  Fly    74 YSNLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNN-HSLSFGKFIKVVSLEP 137

pombe   131 YYSTRSSRQVLSGGRAGKVVLSEKGWLGN-KDTVLQADCGAVYKISWYTTYIAWASDLGITVYS- 193
            .......|.|:..   .|::|.|:..|.. |...|.:..|:|..|.|:..:|||||.:|:.||.
  Fly   138 DSKAHIKRFVVGD---DKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDL 199

pombe   194 ---TEFGKVLGRLEPPKRLPNDEIFPYQLFWQSESRLVIGWSDQIMIVSIQRSNVANELPKISLQ 255
               ...|.:...:.|.:||.|   |...|.|.::..|:|||.|.|.:..|::.|        |::
  Fly   200 NERCSLGLIKWEVPPQERLEN---FRCHLRWSNKHTLLIGWVDTIRVCVIRKRN--------SIE 253

pombe   256 A------LLEIDSI--------VSG--------VLMLGFNILTLAYIANVEDFTSAIPSQRIEGC 298
            |      :..:|.|        |.|        :::|||.          ::.:|...:.|...|
  Fly   254 ASTGNLPVYIVDPISTFQTTFYVCGLAPLSAKQLVVLGFR----------KEKSSCFKALRPVLC 308

pombe   299 RPELRLIDSSFKELCGDAIGLANYSRLQPSDYHLLPDPSSNSHSFVISPNDIVYVRERNQIDHVK 363
            ..|.::.:|  :|:|.|::.|..:.....:||.|......| ..::::|.|||........|.::
  Fly   309 VIEYKMNNS--EEICTDSLTLRGFEEYTVNDYSLGGIIEEN-RFYIVAPKDIVVASLIETDDRIE 370

pombe   364 YLVSKEMYAEAIDAVKKLPEIPPSLQISELAKKYIFHLLGKGQYKEAGMVIPSLYNDNLAEWEQW 428
            :|:....:.||::.:.......|.|.:   ||.||.|||...:|.:|..:...:..::...||:.
  Fly   371 WLIKHSKFEEAMELISANGGNVPVLSV---AKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEE 432

pombe   429 VFVFAENDHLEDIADFLPTG-ENHLSPLVYEMILAQYLATDERTFNKKLHEWPTMLYSVSTIRNA 492
            ||.|.:...|..::.:|||. |..|.|.||||:|.::|..|...|...:.|||:.||....:.||
  Fly   433 VFKFVKCQQLRSVSAYLPTSDECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINA 497

pombe   493 TLKKFKENQKSSTLTESLAFLYLEDNMPIDAFHLYLKLHSELCIDLILQHNLYDEARASVLLLML 557
            ....|:::. ::.|.||||.||........|..:||||.::....||.::.|||.  .|.|::.|
  Fly   498 IHDNFRKHY-ANQLLESLALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDV--ISKLIIPL 559

pombe   558 ISSKGKSSDTKSAMSSMLVQHVHSFPPQEVIMQIHSVPQFLYEYFCEFELMYPNSLMEYGDLKLD 622
            |     ..|...|...:|.:  .....:.|:.|:....::||.|........|:::.:  ...:.
  Fly   560 I-----QLDRDCAFEILLDK--KKIKTEIVVHQLEHNQEYLYWYLDSLLKKDPSNVFQ--KKLIS 615

pombe   623 VFAEFDRKRFFDFLVNTQCYSLDHAAQICKQYNYLDELVYILGRMG--NNKEALMLIINELLDIG 685
            ::|.|||.:...||..::.|.:..|..||||.|:..|:||:||.||  ...|||.:||:.:.||.
  Fly   616 LYAIFDRNKLLPFLKRSKDYDIQEALVICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIE 680

pombe   686 RAIRYVKEQADRELWDDLISYSLDKPEFICTLLENIGTDENARNLLSKIPPGTKLPHMKKSISKL 750
            .||.:.||..|.:||:.||:.....||.:..:|:.|....:...::.||..|..:|::::|:.|:
  Fly   681 MAIEFCKEHDDSDLWNALINEFSKHPEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKM 745

pombe   751 LADHQSQVQLYQSCYKLFKNE 771
            |..:..|.::..|..::..|:
  Fly   746 LRHYNLQGEILSSAQQIQLND 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vps41	NP_593409.2	WD40	<29..254	CDD:225201	61/237 (26%)
		WD40	44..>204	CDD:295369	44/172 (26%)
		WD40 repeat	44..78	CDD:293791	7/39 (18%)
		WD40 repeat	84..118	CDD:293791	11/35 (31%)
		WD40 repeat	123..167	CDD:293791	10/44 (23%)
		WD40 repeat	172..204	CDD:293791	11/35 (31%)
		CLH	<625..712	CDD:128594	36/88 (41%)
		Clathrin	<628..714	CDD:279031	36/87 (41%)
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	8/47 (17%)
		WD40	<42..204	CDD:295369	44/165 (27%)
		WD40 repeat	90..123	CDD:293791	10/33 (30%)
		WD40 repeat	130..168	CDD:293791	9/40 (23%)
		CLH	570..707	CDD:128594	43/140 (31%)
		Clathrin	580..708	CDD:279031	43/129 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	188	1.000	Domainoid score	I751
eggNOG	1	0.900	-	-		E1_KOG2066
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I716
OMA	1	1.010	-	-		QHG54432
OrthoFinder	1	1.000	-	-		FOG0004492
OrthoInspector	1	1.000	-	-		oto100992
orthoMCL	1	0.900	-	-		OOG6_103391
Panther	1	1.100	-	-	LDO	PTHR12616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1654
SonicParanoid	1	1.000	-	-		X3779
TreeFam	1	0.960	-	-
	13	12.860