DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdr2 and par-1

DIOPT Version :9

Sequence 1:	NP_593307.1	Gene:	cdr2 / 2541590	PomBaseID:	SPAC57A10.02	Length:	775	Species:	Schizosaccharomyces pombe
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	199/798 - (24%)
Similarity:	353/798 - (44%)	Gaps:	132/798 - (16%)

- Green bases have known domain annotations that are detailed below.

pombe     2 STISEVGPWELGLSLGSGGPNSSRLAKHRETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIE 66
            :|...:|.::|..::|.|.....:||||..||:...:| |:..::|......::..|:.::::::
  Fly   245 ATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIK-IIDKTQLNPGSLQKLFREVRIMKMLD 308

pombe    67 HPNVLQLIDVISAQEQLFVVVEYMPGGELFDCMLRKGSFTEQDTAKFLWQILCGLEYCHKLHICH 131
            |||:::|..||..::.|::::||..|||:||.::..|...|::......||:..::|||:..|.|
  Fly   309 HPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIH 373

pombe   132 RDLKPENLYLDAHGSIKIGEFGMASIQQPGKLLQTSCGSPHYASPEIIMGRSYDGCASDIWSCGI 196
            ||||.|||.||:..:|||.:||.::...||..|.|.||||.||:||:..|:.|||...|:||.|:
  Fly   374 RDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGV 438

pombe   197 IFFALLTGKLPFDDDNIRSLLLKVCQGQFEMPSNISPQAQHLLYRMLDVDSSTRITMEQIREHPF 261
            |.:.|::|.||||...:|.|..:|.:|::.:|..:|...::||.:.|.::.:.|.::|.|....:
  Fly   439 ILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKW 503

pombe   262 LSCFVHPNISIPIISAPIQPIDPLIVQHL-SLVFRCSDDPMPL----YEKLASQSPLVEKTLYTL 321
            ::.....:...|.|.......||..::.| ::.:..|:....|    |:.:.:        .|.|
  Fly   504 MNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFA--------TYLL 560

pombe   322 LSRHLHPPSSAAVDRNRAVVDDLLGTAAS----NGQQMDEEEIEQAINIPTLAPYPISYAAESVP 382
            |.|....|.|   |.:|:      |::.|    :|..........::..||......|.:|.|.
  Fly   561 LGRKSTDPES---DGSRS------GSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASST- 615

pombe   383 RPATSASPFLTPVTTSGTF---NYSFNATNPQSILQRPATTSSAVPQLPKSVTPGLAYPHDSSML 444
            :|:..||..:.|...:.|.   ..:..|.||.:  ...|..|:|                |.:.:
  Fly   616 KPSRRASSGVGPTNAAATVAAATGAVGAVNPSN--NYNAAGSAA----------------DRASV 662

pombe   445 SSNYRPPSALSPRNFNVSINDPEVQLSRRATSLDMSNDFRMNENDPSIVGNLAASNFPTGMGPPR 509
            .||::..:.:.    :.:|.:...:|:.:            |:...|....:..:...|...|.:
  Fly   663 GSNFKRQNTID----SATIKENTARLAAQ------------NQRPASATQKMLTTADTTLNSPAK 711

pombe   510 KRVTSRMSEHTGNRVVSFPRGSAFNPRVTRFNVGNEQFSNNI---DNNNYNQPYANATMNNSR-- 569
            .|..::.....|||.||...|.......|.:...:.....|:   :.|.:::....:.:.:||
  Fly   712 PRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHF 776

pombe   570 ------RLRTPSGERSMRADLS-----QSPASYDSLNVPKHRRRQSLFSPSSTK--KKLSGSPFQ 621
                  |....||:...|.:.:     .|.||.||    .|..|.|.||..|::  |:.:.:...
  Fly   777 PRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDS----SHPGRMSFFSKLSSRFSKRPTIADEA 837

pombe   622 PKRSFLRRLFSSEPSCKCVYASLVASELEHEILEVLRR-------------WQLLGIGIADIIYD 673
            .|...||..:|.:.:     :.|:..::..:|.|||.:             |.:.|    |...|
  Fly   838 AKPRVLRFTWSMKTT-----SPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHG----DPNTD 893

pombe   674 SVSASISARIKRQNSLNLKPVRF-RISVLAEFFGSQAVFVLESGSSTTFDHLATEFQLIFEDKGF 737
            |: ......:.:...|:|..||| ||                ||:|..|.::|:  ::.|:.|..
  Fly   894 SL-VQWEIEVCKLPRLSLNGVRFKRI----------------SGTSIGFKNIAS--RIAFDLKLX 939

pombe   738 LD--NLELSYFQASASRP 753
            |:  |.| ....|:||||
  Fly   940 LNQTNNE-GNAAATASRP 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdr2	NP_593307.1	STKc_BRSK1_2	8..262	CDD:270983	90/253 (36%)
		S_TKc	10..262	CDD:214567	89/251 (35%)
		Fungal_KA1	627..739	CDD:293402	27/125 (22%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	89/252 (35%)
		S_TKc	253..504	CDD:214567	89/251 (35%)
		UBA_MARK_Par1	525..563	CDD:270522	9/45 (20%)
		MARK1-3_C	839..936	CDD:213381	27/124 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910