DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cnga2 and CG42260

DIOPT Version :9

Sequence 1:	NP_037060.2	Gene:	Cnga2 / 25411	RGDID:	2367	Length:	664	Species:	Rattus norvegicus
Sequence 2:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	229/483 - (47%)
Similarity:	312/483 - (64%)	Gaps:	26/483 - (5%)

- Green bases have known domain annotations that are detailed below.

  Rat   111 HQGDDKGGKDGEGK--------------------GTKKKFELFVLDPAGDWYYRWLFVIAMPVLY 155
            |.|...||..|.|.                    .|..:...||.||||...|.|..|::|..||
  Fly   529 HGGAGSGGGSGPGSHGGQPHHQKPRRTASQRIRAATAARKLHFVFDPAGRLCYYWSMVVSMAFLY 593

  Rat   156 NWCLLVARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLLVKDPKKLRDNYIHT 220
            |:.:::.|..|.::.|....:|..|||.||.:|:.|::...|||:||.|:|..|..|||.:|:::
  Fly   594 NFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDGVLQTDALKLRTHYMNS 658

  Rat   221 LQFKLDVASIIPTDLIYFAVGIHSPEVRFNRLLHFARMFEFFDRTETRTSYPNIFRISNLVLYIL 285
            ..|.:|...::|.|.:|.::|.:| .:|..||:...|.:.|.||||..|:|||:||.:.|:.|:|
  Fly   659 TIFYIDCLCLLPLDFLYLSIGFNS-ILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTALIHYLL 722

  Rat   286 VIIHWNACIYYVISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDE 350
            ||.|||.|:|::|.|:.|||...|||   .|.|...:.::|:...||.||.|||||:.|.|....
  Fly   723 VIFHWNGCLYHIIHKNNGFGSRNWVY---HDSESADVVKQYLQSYYWCTLALTTIGDLPKPRSKG 784

  Rat   351 EYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKDMEAKVIKWF 415
            ||:|||...|.|:::|||::|:|.:::::::|.|.|||||:|.||.||:.|:|...::.||||||
  Fly   785 EYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWF 849

  Rat   416 DYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPG 480
            ||||..:|..||...:..||.||:|||||||||.|||:|.|||:.|||.|.||||:|||.:||||
  Fly   850 DYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVLRLRPVLFSPG 914

  Rat   481 DYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSL 545
            |||||||::||||||:..|:|.||||:|.|..|.|.|||.||||||||:  ...||||||::||:
  Fly   915 DYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNM--GTAGNRRTASVRSV 977

  Rat   546 GYSDLFCLSKDDLMEAVTEYPDAKKVLE 573
            ||||||.|||.|:.:.:.|||.|:..||
  Fly   978 GYSDLFVLSKKDMWDVLKEYPAARVRLE 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cnga2	NP_037060.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Ion_trans	142..384	CDD:395416	97/241 (40%)
		Radical_SAM	417..>470	CDD:418514	32/52 (62%)
		CAP_ED	456..572	CDD:237999	74/115 (64%)
		CLZ	572..639	CDD:406832	2/2 (100%)
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	97/241 (40%)
		CAP_ED	890..1004	CDD:237999	74/115 (64%)
		DUF4655	1084..>1154	CDD:317882
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5370
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920