DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sre2 and Mitf

DIOPT Version :9

Sequence 1:	NP_595229.1	Gene:	sre2 / 2541044	PomBaseID:	SPBC354.05c	Length:	793	Species:	Schizosaccharomyces pombe
Sequence 2:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	174/830 - (20%)
Similarity:	277/830 - (33%)	Gaps:	245/830 - (29%)

- Green bases have known domain annotations that are detailed below.

pombe    58 ISHVPSVGTRGIPRSYSMASAYPYQVNSNSMDASTAFNLNQDVADKPMLARNSID------SSIN 116
            :||..|   |.:....::.|:...:|.......|.|.|::: ....|:|..:..|      ::|.
  Fly    64 MSHNES---RDLVNGPNICSSMDIEVGEEPPTTSFADNIDK-ACPLPVLRSSDCDCVPLCMTNIR 124

pombe   117 TELGPLESNHWFTQAQDHSRQYSSSWDPSIDPFEVKNSLHDSTDLSI--THHPH---LPINHQGN 176
            ..:|           .|...:.....||||         .|..|:||  |..|.   ||....|.
  Fly   125 VSVG-----------IDKDLEMILEMDPSI---------VDLGDISIDETAEPRIVGLPPLSGGP 169

pombe   177 TWKHANES--------LQ---------------------------SNQGPVPNTKFVGLETTQTD 206
            |:|.|..:        ||                           |.|| :..::|:...:|...
  Fly   170 TFKTATPTSRTQLKLQLQREQQQQMMIQQQTLDTAMDPKMHLLFGSGQG-LMESEFIDSGSTSAC 233

pombe   207 SYQQSSVNSVVKIEEADATYALREESGQ-----------------FNTFTGAENPSISPHSLNPN 254
            ....||:..:.::.:.|  ..:...||.                 ....|..|||: ..|.:...
  Fly   234 GSGSSSLEQMSQLVQMD--NLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPT-RYHVIQKQ 295

pombe   255 FPQYTE------KPA--------LTLLQSPKQNSNYDTSNFQNSVSDSSMQFTNEGMPSPV--KG 303
            ..|..:      ||:        :.|..:.....|...|:.|..:.|...:....|..|.|  |.
  Fly   296 KNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKR 360

pombe   304 IMSSDDAVAFN--------FSQYSTVYPQNAPENGNEFETPNKLKRT----VSSPCASISSKRSY 356
            ||.||||:..:        ....:.:.|.....|.:....|....||    :|...:|:||.||.
  Fly   361 IMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSS 425

pombe   357 GDIAQD---CSYISSKTNGGGP-SDSPSSSSTSVRGSVNDSNSPISSSATFAIQSNGVEPVGLST 417
            ..|...   .|..||..:...| |.|.||.:||| ...:|....|..:.:|....|....:.:..
  Fly   426 SGIVNSIRISSTSSSLQSTSAPISPSVSSVATSV-SEPDDIFDDILQNDSFNFDKNFNSELSIKQ 489

pombe   418 QEQNLSPL---------SKRSAHNMIEKRYRSNLNDKIAELRDAVPTLRSGYNSTTADELKGTYV 473
            :.|||:..         .|:..|||||:|.|.|:||:|.||...:|.....:.....|
  Fly   490 EPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRD------- 547

pombe   474 PLSRKLNKATILSKATEYIKSL-----------------QSKNKKLIEENKILQKRLSEYTSVIQ 521
               .:.||.|||..:.:|||.|                 :.:|:||:...|.|:.:...:..::.
  Fly   548 ---IRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLS 609

pombe   522 ----ASLTAPSQPASLSLLGPPGNTPGHRNV--PPILKR--------SSIGTPSQQAYFPDAPHN 572
                .||:||:||...|....|..:...|::  .|:.|:        .::|......:..|
  Fly   610 ENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMED---- 670

pombe   573 CHSVPQNSSYPRPPMQVNRSPIDSMQTIPHA-----------NFNEM-HNAYSSRYPLKYSKSCN 625
            |....|...    ||..:.|.:.|....|.:           ||:|. .:.:..:..|.....|.
  Fly   671 CKYAVQGGD----PMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKSSLASDDCCG 731

pombe   626 AVSHTSMM----------HP--QEYGG-----SLPSSTVPSDYNQ------PQLVSPRAQADQQG 667
            ....||..          ||  ..:.|     ||..|...|::::      |.|.|
  Fly   732 INCSTSCYIQHQLTSREGHPNHSHHTGIREIHSLSDSAQNSEFSRLEHCDDPLLSS--------- 787

pombe   668 LSYKNVGRAVLNGLVGLETVHMLTNPDDAGSSNRFSMSVLPISPSLHSIL 717
             |::::|           ||       |....|...||.:.:..||.|::
  Fly   788 -SHRSLG-----------TV-------DEDQHNSVDMSAVMVHDSLSSLV 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sre2	NP_595229.1	HLH	427..496	CDD:278439	25/85 (29%)
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	8/39 (21%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	25/74 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940