DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kin1 and par-1

DIOPT Version :9

Sequence 1:	NP_596106.1	Gene:	kin1 / 2540792	PomBaseID:	SPBC4F6.06	Length:	891	Species:	Schizosaccharomyces pombe
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	1008	Identity:	263/1008 - (26%)
Similarity:	403/1008 - (39%)	Gaps:	244/1008 - (24%)

- Green bases have known domain annotations that are detailed below.

pombe     3 YRTNNVPVG---------------NETKSAALNALPKIKISDSPNRHHNLVDAFMQSPSYSTQPK 52
            |.||::...               :::.:|.:.:||.   :.:|..:.|.:...:.|.:.:|...
  Fly    56 YATNSISTSSHSVKDQQQQQQQQQHDSANANIVSLPP---TTTPVANTNTMMPIVTSSNSATSNS 117

pombe    53 SAVEPL------------GLSFSPGYISPSSQSPHHGPVRSP-----------------SSRKPL 88
            :|..|.            .:|..|..:|.|:.:.:|....|.                 ||....
  Fly   118 TAATPTPASGAAATGGVGSVSQGPATVSASAANTNHSHQHSHQHHHHVANNMTTDGARLSSNNSA 182

pombe    89 PASPSRTRDHSLRVPVSG------------HS----------------------YSADEKPRERR 119
            ..:.|....|....|.||            ||                      .||..:.|...
  Fly   183 VVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATE 247

pombe   120 KVIGNYVLGKTIGAGSMGKVKVAHHLKTGEQFAIKIV--TRLHPDITKAKAAASAEATKAAQSEK 182
            :.||.|.|.||||.|:..|||:|.||.||::.||||:  |:|:|...:
  Fly   248 EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQ----------------- 295

pombe   183 NKEIRTVREAALSTLLRHPYICEARDVYITNSHYYMVFEFVDGGQMLDYIISHGKLKEKQARKFV 247
                :..||..:..:|.||.|.:...|..|....|::.|:..||::.||::.||::|||:||...
  Fly   296 ----KLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKF 356

pombe   248 RQIGSALSYLHQNSVVHRDLKIENILISKTGDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELL 312
            |||.||:.|.||..::|||||.||:|:....:|||.|||.||.:...|:|.|||||..:|||||.
  Fly   357 RQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELF 421

pombe   313 NAQPYIGPEVDVWSFGIVLYVLVCGKVPFDDQNMSALHAKIKKGTVEYPSYLSSDCKGLLSRMLV 377
            ..:.|.||||||||.|::||.||.|.:|||...:..|..::.:|....|.|:|:||:.||.:.||
  Fly   422 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLV 486

pombe   378 TDPLKRATLEEVLNHPWM--------IRNYEGPPASFAPERSPITLPLDPEIIREMNGFDFGPPE 434
            .:|.|||:||.::...||        ::.|..|.|..|          ||:.|..:....:...|
  Fly   487 LNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLA----------DPKRIEALVAMGYNRSE 541

pombe   435 KIVRELTKVISSEAYQSLAKTGFYSGPNSADKKKSFFEFRIRHAAHDIENPILPSLSMNTDIYDA 499
             |...|::|...:.:.:....|..|....:|..:|.....:|:.:.:.......|.|:.:..:..
  Fly   542 -IEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRG 605

pombe   500 FHPLISIYYLVSERRVYEKGGNWNRIAKTPVSSVPSSPVQPT-SYNRTLPPMPEVVAYKGDEESP 563
            .|..||.......||.....|..|..|....::.....|.|: :||            .....:.
  Fly   606 VHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYN------------AAGSAAD 658

pombe   564 RVSRNTSLARRKPLPDTESHSPSPSATSSIKKNPSSIFRRFSSRRKQNKSSTSTLQISAPLETSQ 628
            |.|..::..|:..:         .|||  ||:|.:    |.:::.::..|:|..:..:|. .|..
  Fly   659 RASVGSNFKRQNTI---------DSAT--IKENTA----RLAAQNQRPASATQKMLTTAD-TTLN 707

pombe   629 SPPTPRTKPSHKPPVSYKNKLVTQSAI-GRSTSVRE------------------GRYAGISSQMD 674
            ||..|||...:.|....:....|...| .|||::.|                  .|....|:...
  Fly   708 SPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKS 772

pombe   675 SLNMDSTGPSASNMANAPPSVRNNRVLNPRGAS-----LGH-GRMS-----TSTTNRQKQILNET 728
            |.:.....||.|...:.....|||..|...|.|     ..| ||||     :|..:::..|.:|.
  Fly   773 SRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEA 837

pombe   729 MGNPVDKNSTSPSKSTDKLDPIKPVFLKGLFSVSTTSTKSTESIQRDLIRVMGMLDIEYKEIKGG 793
                                 .||..|:..:|:.|||....:.|.:.:..|:...:.:|::
  Fly   838 ---------------------AKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQ---- 877

pombe   794 YACLYKPQGIRTPTKSTSVHTRRKPSYGSNSTTDSYGSVPDTVPLDDNGESPASNLAFEIYIVKV 858
                      |.......||        .:..|||.                   :.:||.:.|:
  Fly   878 ----------RERFVLWCVH--------GDPNTDSL-------------------VQWEIEVCKL 905

pombe   859 PILSLRGVSFHRISGNSWQYKTLASRILNELKL 891
            |.|||.||.|.||||.|..:|.:||||..:|||
  Fly   906 PRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kin1	NP_596106.1	STKc_Kin1_2	123..395	CDD:270979	115/273 (42%)
		S_TKc	125..395	CDD:214567	114/271 (42%)
		MARK_C_like	753..889	CDD:213377	34/135 (25%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	114/272 (42%)
		S_TKc	253..504	CDD:214567	114/271 (42%)
		UBA_MARK_Par1	525..563	CDD:270522	7/38 (18%)
		MARK1-3_C	839..936	CDD:213381	36/137 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	44	1.000	Domainoid score	I3618
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I699
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X401
TreeFam	0	0.000	Not matched by this tool.
	3	3.050