Protein Alignment BRWD3 and BDF1

DIOPT Version :10

• Sequence 1: NP_694984.5
• Gene: BRWD3 / 254065
• HGNCID: 17342
• Length: 1802
• Species: Homo sapiens
• Sequence 2: NP_013503.1
• Gene: BDF1 / 851115
• SGDID: S000004391
• Length: 686
• Species: Saccharomyces cerevisiae
• Alignment Length: 661
• Identity: 140/661 - (21%)
• Similarity: 232/661 - (35%)
• Gaps: 208/661 - (31%)

Human  1090 DNNEREKMSPWDM--EPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQ 1152
            |.|.:::: |.::  ||.|            .|..:.::..|...|.......|:        :.
Yeast   116 DENSKQEL-PMEVPKEPAP------------APPPEPDMNNLPQNPIPKHQQKHA--------LL 159

Human  1153 GINHLLSLDFASPFAVPVD--LSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEH 1215
            .|..:..|..|.||..|||  ....|.|...:..|.||:||.|:|....|.....:..:...:.:
Yeast   160 AIKAVKRLKDARPFLQPVDPVKLDIPFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVN 224

Human  1216 NARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEERNSTDAEEDTEIVDLDSDG 1280
            |:..||.|::.|.:.|:.:.....:.:.:....|.    ..:.|:.|.|: |:||..||...:.
Yeast   225 NSIKFNGPNAGISQMARNIQASFEKHMLNMPAKDA----PPVIAKGRRSS-AQEDAPIVIRRAQ- 283

Human  1281 PGTSSGR-------------------KVKCRGRRQSLKCNPDAWKKQCKELLSLIYEREDSE--- 1323
              |.:||                   |.|.:..:|::|.        |:.:|..:..::.:.
Yeast   284 --THNGRPKRTIHPPKSKDIYPYESKKPKSKRLQQAMKF--------CQSVLKELMAKKHASYNY 338

Human  1324 PFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKETLEAGNYGSPL 1388
            ||.:|.|.:|..             :|          .|.|.:..|:|..|:.:.|....|.:..
Yeast   339 PFLEPVDPVSMN-------------LP----------TYFDYVKEPMDLGTIAKKLNDWQYQTME 380

Human  1389 EFYKDVRQIFNNSKAYTSNKKSRIYSMM-LRLSALF-----------------ESHIKNIISEYK 1435
            :|.:|||.:|.|  .||.|....|.:|| .||..:|                 :|..:....:|:
Yeast   381 DFERDVRLVFKN--CYTFNPDGTIVNMMGHRLEEVFNSKWADRPNLDDYDSDEDSRTQGDYDDYE 443

Human  1436 S---------------AIQ-----------------SQKRRRPRYRKRL-------------RSS 1455
            |               |||                 .|:..:.|..:||             ||.
Yeast   444 SEYSESDIDETIITNPAIQYLEEQLARMKVELQQLKKQELEKIRKERRLARGSKKRGKRSKGRSG 508

Human  1456 SSSLSSSGAPSPKGK--------QKQMKLQPKNDQNTS-----VSHARTSSPFSSPVSDAAEGLS 1507
            |.:.||.|....|.|        .|::..:..||..||     :...:.|.|..|. .|..| |.
Yeast   509 SKNASSKGRRDKKNKLKTVVTYDMKRIITERINDLPTSKLERAIDIIKKSMPNISE-DDEVE-LD 571

Human  1508 LYLLDDEPDGPFSSSSFGGY-SRSGNSHDPGKAKSFRNRVLPVKQDHSLDGPLTNGDGRE----- 1566
            |..||:.......::.|..| |.||.|                   :.|||  |:|..|:
Yeast   572 LDTLDNHTILTLYNTFFRQYESSSGAS-------------------NGLDG--TSGVTRDASSLS 615

Human  1567 PRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSES----------GELGSSLSSESTCGS 1621
            |.:...||..|.:     :..|::.::..|.|:.|:..:|          |::.|:..:..:..|
Yeast   616 PTSAGSRKRRSKA-----LSQEEQSRQIEKIKNKLAILDSASPLSQNGSPGQIQSAAHNGFSSSS 675

Human  1622 DSDSESTSRTD 1632
            |.|..|.|..:
Yeast   676 DDDVSSESEEE 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_694984.5	WD 1	170..209
		WD40	<178..496	CDD:441893
		WD40 repeat	183..220	CDD:293791
		WD 2	213..251
		WD40 repeat	226..262	CDD:293791
		WD 3	255..297
		WD40 repeat	267..313	CDD:293791
		WD 4	307..347
		WD40 repeat	321..359	CDD:293791
		WD 5	353..393
		WD40 repeat	365..425	CDD:293791
		WD 6	400..452
		WD40 repeat	426..462	CDD:293791
		WD 7	456..495
		WD40 repeat	468..493	CDD:293791
		WD 8	502..542
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..910
		Bromo_WDR9_I_like	1130..1242	CDD:99958	26/113 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1262..1292		12/48 (25%)
		Bromodomain	1301..1442	CDD:445827	36/193 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1326..1361		4/34 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1438..1500		22/104 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1520..1725		28/129 (22%)
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	64/316 (20%)
		Bromodomain	<339..417	CDD:445827	28/102 (27%)
		PTZ00108	<386..647	CDD:240271	65/290 (22%)
		BET	527..589	CDD:435704	14/63 (22%)