Protein Alignment BRWD3 and brwd3

DIOPT Version :10

• Sequence 1: NP_694984.5
• Gene: BRWD3 / 254065
• HGNCID: 17342
• Length: 1802
• Species: Homo sapiens
• Sequence 2: XP_021327269.2
• Gene: brwd3 / 553209
• ZFINID: ZDB-GENE-100921-43
• Length: 1741
• Species: Danio rerio
• Alignment Length: 1881
• Identity: 1110/1881 - (59%)
• Similarity: 1314/1881 - (69%)
• Gaps: 219/1881 - (11%)

Human     1 MAAAP-TQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAAN 64
            |||.| :|||||||||||||||||||.||||:|:|||.|:::||:|...:|::.:|||:|.|..|
Zfish     1 MAAEPCSQIEAELYYLIARFLQSGPCQKSAQMLLQELHEYEIIPKRWSCDGEQFKRSFDDWVLLN 65

Human    65 AHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGR 129
            .|||.||||::|:::|||:||.||.|||||.:|||.|||||||.||....|||:|||.|||||||
Zfish    66 QHIPADYLLRVCKQVGPLIDKHIPPSVPGVHSLLGTGRQSLLRTAKSSSHTLWSGSAVAALHRGR 130

Human   130 PPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRR 194
            |||.|::..|.||:|:|..|||.||.:||||.|||.||||:|||:||||||||||||||||:|||
Zfish   131 PPEPPISCAKSPNIVSIIGARQKTGVARFGHAFPSCAYQHMKMHRRILGHLSSVYCVAFDRTGRR 195

Human   195 IFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAV 259
            ||||||||||||||||:||||||||||:||||||.||:||||:|:.||||:||||||||||||||
Zfish   196 IFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCLRTCAPVAV 260

Human   260 LQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCS 324
            ||||:||||||||.||..|::|:|.:|||||.:|||||:..:|||.|:||||.||||||||||||
Zfish   261 LQGHTASITSIQFSPSALGSSRFLATTGADGMVCFWQWNSFSMKFVDKPVKFMERSRPGVQISCS 325

Human   325 SFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTAR 389
            ||||||:|:.||.|||:||:||||:|:|.|.::|:||||||||:|||||.|||||||||||||||
Zfish   326 SFSSGGLFLATGGTDHMIRVYYLGTEMPVKFSDLDSHTDKVVAIQFCNNTDSLRFVSGSRDGTAR 390

Human   390 IWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSIT 454
            ||.||||||||.||||.|::.|:.:.||:||.|||.||||||||.|.::||||:|.|||||||..
Zfish   391 IWHYQQQEWKSTVLDMTTRLPGSAVISGDDKSTKLVVTMVAWDRCDRSIITAVSNCLLKVWNSTN 455

Human   455 GQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDC 519
            |||||.|.|||||||||||||||.||:|||||||||::|||.:|.||||:|||||||||||||||
Zfish   456 GQLLHVLLGHDDEVFVLEAHPFDSRILLSAGHDGNIYVWDLSKGQKIRNFFNMIEGQGHGAVFDC 520

Human   520 KFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLM 584
            |||.||.||||||||||||:||||||:.||.||||||||||:||||||:||:|||||||||||||
Zfish   521 KFSVDGQHFACTDSHGHLLIFGFGCSQPYEMIPDQMFFHTDFRPLIRDSNNFVLDEQTQQAPHLM 585

Human   585 PPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTND--QDESIL 647
            ||||||||||||||.:.|||||||||||:|||:|||||:||||||||||||||||.|  |:||.|
Zfish   586 PPPFLVDVDGNPHPPRCQRLVPGRENCKEEQLVPQLGYMANGDGEVVEQVIGQQTADESQEESPL 650

Human   648 DGIIRELQREQDLRLINEGDVPHLPVNRA----YSVNGALRSPNMDISSSPNIRLRRHSSQIEGV 708
            |.:||:||.:||.|           ||:|    ..|.|...||       ||:.||| |.|:|||
Zfish   651 DDLIRQLQNQQDER-----------VNQANPAGAEVAGGPLSP-------PNVGLRR-SGQVEGV 696

Human   709 RQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKK--PSY 771
            ||||||||||||||||||:||||||||||:..|:.||.|:||.|||::|.|.|.:|||:|  ||.
Zfish   697 RQMHNNAPRSQMATERDLLAWSRRVVVNEVQAGIFRVMEDCRLAKGEVERSYYIIEKKRKSVPST 761

Human   772 TTQRNDYEPSCGRSLRRTQRKRQ---HTYQTRSNIEHNSQASCQ----NSGVQEDSDSSSEEDET 829
            .:|..|..    |:|||.|||.|   |.|||||........|.|    |...:.:|:|.:|::|.
Zfish   762 GSQPGDNV----RTLRRPQRKAQQKRHAYQTRSTRTRRRSGSVQSFSRNEETEVESESEAEQEED 822

Human   830 VGTSDASVEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSS--DEENLK 892
            ...:.....:...:|:::||||||||||||||||||||||||||.||:..|...|||  |||...
Zfish   823 QNENSDGTSEGETQWENDSSSSDSSSEYSDWTADAGINLQPPKRTTRRPARVAVSSSSEDEEGTG 887

Human   893 SLE----------ERQKKPKQTRKKKGGLVSIAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELI 947
            ..|          |::|||||.....|.|        |||..|.||::|||||||||||||||||
Zfish   888 QGEGEAAQTTKQAEKKKKPKQRSVPAGEL--------EEWLPPSWIMETIPRRSPFVPQMGDELI 944

Human   948 YFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPIS 1012
            ||||||:||||||.::|.||:|.||||||:::||:||.||:||||||||||||||||||.||..|
Zfish   945 YFRQGHQAYVRAVSRAKAYSINPQKQPWNRLNLRDQESVKVVGIKYEVGPPTLCCLKLAILDLTS 1009

Human  1013 GKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEY 1077
            ||||.||||:||||||||||||||.||||||||||||.|.|||||||||||||::|.|:||:.||
Zfish  1010 GKMTNESFSLKYHDMPDVIDFLVLQQFYNEAKERNWQPGQRFRSIIDDAWWFGSLECQEPFESEY 1074

Human  1078 PDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHS 1142
            |||.||||.|.|||.|||||||||:|||||....|:|.|..|||:::||.||||.|||||||.|:
Zfish  1075 PDSLFQCYIVRWDNGEREKMSPWDIEPIPEEAPLPEEDGDSVPVTEDELQALLYSPQEGEWGLHT 1139

Human  1143 RDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALM 1207
            |||||||||..|:.||:||.|..|:.||:|..||||||||||.|||:|||.||.:||||||||||
Zfish  1140 RDEECERVITAIDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALM 1204

Human  1208 WEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEERNSTDAEEDTE 1272
            ||||||||||||||||.||||.|||.|:|||||||.||:||||||.|||:|:|   .:..|::.|
Zfish  1205 WEVRYIEHNARTFNEPQSPIVTAAKTVSDVLLRFIRDQNCTDILDLYNKMKSE---FSSEEDEEE 1266

Human  1273 IVDLDSDGPGTSSG-RKVKCRGRRQSLKCNPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPG 1336
            .||:|||.||||:| |:.....:::.:..:.:||.||||:|:..:....||||||||.||.:||
Zfish  1267 TVDVDSDTPGTSTGQRRSNSTPQKRGVVLDINAWHKQCKDLVRRMIVSSDSEPFRQPVDLFTYP- 1330

Human  1337 HQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNS 1401
                                    ||:|:||||:|..||.|||..|||.:|:||.||||.||:||
Zfish  1331 ------------------------DYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNS 1371

Human  1402 KAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQSQKRRRPRY--RKRLRSSSSSLSSSGA 1464
            ||||.|||||||||.|.|||.||:.|..|||:||||:|:|:|.:.|.  .|||:|||.:
Zfish  1372 KAYTPNKKSRIYSMTLSLSAFFENQIIPIISDYKSAVQNQRRSQQRLMCSKRLQSSSPN------ 1430

Human  1465 PSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSR 1529
             |||||||..|   |..|.::.:..|.||. .|.|:...|       |.:|....||||....|.
Zfish  1431 -SPKGKQKSGK---KTLQMSAKARTRKSSQ-DSNVAQVDE-------DSQPSSSSSSSSSSSSSS 1483

Human  1530 SGNSHDPGKAKSFRNRVLPVKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKE 1594
            |.:|...|..:..|::|...|.....   |.|| ||..|    |:....:||     ||..|.:.
Zfish  1484 SFSSEQAGANRVTRSQVTSSKSSGVF---LPNG-GRSSR----RRRAVLTEE-----GEVSECES 1535

Human  1595 TKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRTDQDYVD-GDHDYSKFIQTRPKRKL---- 1654
            |       :|.|....:|.||.:|..|.|:|:.:|.....:.| |||||||..|.:.|.|.
Zfish  1536 T-------SSSSSSTSASSSSSATSSSSSESDDSSAEVSGFADGGDHDYSKAPQHKQKGKAPAPP 1593

Human  1655 ----------------RKQHGNGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGG 1703
                            ||:.|..:::
Zfish  1594 PPPSPPPPAPTIDNPKRKRKGEEEQS--------------------------------------- 1619

Human  1704 TRGRGRGRGGRGASRGATRAKRARIADDEFD---------------------------TMFSGRF 1741
              .....|..|.:||.....:.....|||.:                           ...:.|.
Zfish  1620 --AEPEKRPRRTSSREEEEEEEEEEVDDEPEEEEEPDEEEEPEEEEEESDDENVISPSKRSNQRT 1682

Human  1742 SRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY 1802
            .:..|:.|||||||||||||||:.:.  .|.||||||.|||||||:|||:|||||||||.:
Zfish  1683 PKSGRVNTRNQGRRTVLYNDDSEEEG--PTSDPLNLGMSRSGRVRRMTERARVSHLMGWTH 1741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_694984.5	WD 1	170..209		35/38 (92%)
		WD40	<178..496	CDD:441893	248/317 (78%)
		WD40 repeat	183..220	CDD:293791	34/36 (94%)
		WD 2	213..251		30/37 (81%)
		WD40 repeat	226..262	CDD:293791	29/35 (83%)
		WD 3	255..297		30/41 (73%)
		WD40 repeat	267..313	CDD:293791	29/45 (64%)
		WD 4	307..347		31/39 (79%)
		WD40 repeat	321..359	CDD:293791	25/37 (68%)
		WD 5	353..393		32/39 (82%)
		WD40 repeat	365..425	CDD:293791	45/59 (76%)
		WD 6	400..452		33/51 (65%)
		WD40 repeat	426..462	CDD:293791	26/35 (74%)
		WD 7	456..495		32/38 (84%)
		WD40 repeat	468..493	CDD:293791	21/24 (88%)
		WD 8	502..542		35/39 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..910		69/162 (43%)
		Bromo_WDR9_I_like	1130..1242	CDD:99958	86/111 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1262..1292		13/30 (43%)
		Bromodomain	1301..1442	CDD:445827	74/140 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1326..1361		7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1438..1500		24/63 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1520..1725		52/225 (23%)
brwd3	XP_021327269.2	None