DRSC/TRiP Functional Genomics Resources

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Protein Alignment BRWD3 and smu-1

DIOPT Version :10

Sequence 1:NP_694984.5 Gene:BRWD3 / 254065 HGNCID:17342 Length:1802 Species:Homo sapiens
Sequence 2:NP_493279.1 Gene:smu-1 / 173175 WormBaseID:WBGene00004895 Length:510 Species:Caenorhabditis elegans


Alignment Length:517 Identity:111/517 - (21%)
Similarity:198/517 - (38%) Gaps:142/517 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    15 LIARFLQSGPCNKSAQVLVQELEEHQLIPRRLD-------WEG--------KEHRRS-FEDLVAA 63
            |:||  |:.|     .:|:::::..:.  .||:       ::|        ||.||| ....:::
 Worm    96 LVAR--QTDP-----MILLKQIDPDRF--ARLESLINRPYFDGQEVYGDVSKEKRRSVIAQTLSS 151

Human    64 NAH-IPPDYLLKICERIGPLLDKEIPQSV--PGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAAL 125
            ..| :.|..||.:   :|..|..::.|.:  ||....|..|:.:.....::              
 Worm   152 EVHVVAPSRLLSL---LGQSLKWQLHQGLLPPGTAIDLFRGKAAQKEQIEE-------------- 199

Human   126 HRGRPPELPVNYVK------PPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHK--------RI 176
               |.|.:....:|      |.:.|....|..|...|:.|.|...: |.:.|:.|        .:
 Worm   200 ---RYPTMMARSIKFSTKSYPESAVFSPDANYLVSGSKDGFIEVWN-YMNGKLRKDLKYQAQDNL 260

Human   177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATL-RGHSAEISDMAVNYENTLIAAG 240
            :...::|.|::|.|....:.|||.|..:|:|..:.|..|... |.|:..:..:..:.:|:.|.:|
 Worm   261 MMMDAAVRCISFSRDSEMLATGSIDGKIKVWKVETGDCLRRFDRAHTKGVCAVRFSKDNSHILSG 325

Human   241 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVKTMKFR 305
            ..|.||||..:::...:..::|||:.||.:::  |.:|  .::.|...||:|..|.         
 Worm   326 GNDHVVRVHGMKSGKCLKEMRGHSSYITDVRY--SDEG--NHIISCSTDGSIRVWH--------- 377

Human   306 DRPVKFTERSRPGVQISC-SSFSSGGMFITTGSTDHVIR--IYYLGSEVPEKIAELESHTDKVVA 367
                        |....| |:|       ..||.|:.|.  |....|:.|:.|....|:|..||.
 Worm   378 ------------GKSGECLSTF-------RVGSEDYPILNVIPIPKSDPPQMIVCNRSNTLYVVN 423

Human   368 VQFCNNGDSLR-FVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAW 431
            :    :|..:| ..||.|         ::.::.:.:|.          |.||            |
 Worm   424 I----SGQVVRTMTSGKR---------EKGDFINCILS----------PKGE------------W 453

Human   432 DRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIW 493
                  ......:.::..:..::|.|..||...:.....|..|| .|.:|.|...||.:.:|
 Worm   454 ------AYAIAEDGVMYCFMVLSGTLETTLPVTERLPIGLAHHP-HQNLIASYAEDGLLKLW 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRWD3NP_694984.5 WD 1 170..209 12/46 (26%)
WD40 <178..496 CDD:441893 73/321 (23%)
WD40 repeat 183..220 CDD:293791 12/37 (32%)
WD 2 213..251 11/38 (29%)
WD40 repeat 226..262 CDD:293791 8/35 (23%)
WD 3 255..297 12/41 (29%)
WD40 repeat 267..313 CDD:293791 9/45 (20%)
WD 4 307..347 9/42 (21%)
WD40 repeat 321..359 CDD:293791 11/40 (28%)
WD 5 353..393 10/40 (25%)
WD40 repeat 365..425 CDD:293791 11/60 (18%)
WD 6 400..452 5/51 (10%)
WD40 repeat 426..462 CDD:293791 4/35 (11%)
WD 7 456..495 12/38 (32%)
WD40 repeat 468..493 CDD:293791 8/24 (33%)
WD 8 502..542
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..910
Bromo_WDR9_I_like 1130..1242 CDD:99958
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1262..1292
Bromodomain 1301..1442 CDD:445827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1326..1361
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1438..1500
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1520..1725
smu-1NP_493279.1 LisH_TPL 8..37 CDD:375350
CTLH 41..92 CDD:128914
WD40 <214..508 CDD:441893 82/368 (22%)
WD40 repeat 219..256 CDD:293791 9/37 (24%)
WD40 repeat 267..303 CDD:293791 12/35 (34%)
WD40 repeat 311..346 CDD:293791 8/34 (24%)
WD40 repeat 352..388 CDD:293791 13/67 (19%)
WD40 repeat 443..487 CDD:293791 9/71 (13%)
Blue background indicates that the domain is not in the aligned region.

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