DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPBC25B2.01 and eEF1alpha1

DIOPT Version :9

Sequence 1:	NP_001342767.1	Gene:	SPBC25B2.01 / 2540430	PomBaseID:	SPBC25B2.01	Length:	592	Species:	Schizosaccharomyces pombe
Sequence 2:	NP_001286321.1	Gene:	eEF1alpha1 / 36271	FlyBaseID:	FBgn0284245	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	439	Identity:	167/439 - (38%)
Similarity:	242/439 - (55%)	Gaps:	34/439 - (7%)

- Green bases have known domain annotations that are detailed below.

pombe   178 VHLVVTGHVDSGKSTMLGRIMFELGEINSRSMQKLHNEAANSGKGSFSYAWLLDTTEEERARGVT 242
            :::||.|||||||||..|.::::.|.|:.|:::|...||...|||||.|||:||..:.||.||:|
  Fly     8 INIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGIT 72

pombe   243 MDVASTTFESDKKIYEIGDAPGHRDFISGMIAGASSADFAVLVVDSSQNNFERGFLENGQTREHA 307
            :|:|...||:.|....|.|||||||||..||.|.|.||.|||:|.:....||.|..:||||||||
  Fly    73 IDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHA 137

pombe   308 YLLRALGISEIVVSVNKLDLMS--WSEDRFQEIKNIVSDFLIKMVGFKTSNVHFVPISAISGTNL 370
            .|...||:.:::|.|||:|...  :||.|::|||..||.: ||.:|:..:.|.|||||...|.|:
  Fly   138 LLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSY-IKKIGYNPAAVAFVPISGWHGDNM 201

pombe   371 IQKDSSDLYKWYK------------GPTLLSALDQLVPPEKPYRKPLRLSIDDVYRSPRSVTV-T 422
            ::..::  ..|:|            |.||:.|||.::||.:|..|.|||.:.|||:.....|| .
  Fly   202 LEPSTN--MPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGTVPV 264

pombe   423 GRVEAGNVQVNQVLYDVSSQEDAYVKNVIRNSDPSSTWAVAGDTVTLQLADIEVNQLRPGDILSN 487
            ||||.|.::...|:....:.....||:|..:.:.... ||.||.|...:.::.|.:||.|.:..:
  Fly   265 GRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQE-AVPGDNVGFNVKNVSVKELRRGYVAGD 328

pombe   488 YE-NPVRRVRSFVAEIQTFDIHGPILSGSTLVL-----HLGRTVTSVSLKIVTVNNKRS----RH 542
            .: ||.:....|.|::...:..|.|.:|.|.||     |:......:..|:...:.|.:    :.
  Fly   329 SKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKF 393

pombe   543 IASRKRALVRISFLDGLFPLCLA--EECPALGRFILRRSGDTVAAGIVK 589
            |.|...|:|.   |....|||:.  :|.|.||||.:|....|||.|::|
  Fly   394 IKSGDAAIVN---LVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIK 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPBC25B2.01	NP_001342767.1	HBS1_N	<34..80	CDD:312481
SPBC25B2.01	NP_001342767.1	TEF1	171..592	CDD:227581	167/439 (38%)
eEF1alpha1	NP_001286321.1	PTZ00141	1..457	CDD:185474	167/439 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
TreeFam	0	0.000	Not matched by this tool.
	4	3.810