DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cct8 and CCT8

DIOPT Version :9

Sequence 1:	NP_595406.1	Gene:	cct8 / 2540305	PomBaseID:	SPBC337.05c	Length:	546	Species:	Schizosaccharomyces pombe
Sequence 2:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	257/536 - (47%)
Similarity:	381/536 - (71%)	Gaps:	2/536 - (0%)

- Green bases have known domain annotations that are detailed below.

pombe     1 MALRVPKASG-PQLFREGYRIMQGVEDAVIRNCNAIRELSEITRTSLGPNGKNKIVVNHLQQTFL 64
            |||.||||.| .|:.::|.|:..|:|:||.||.:|.:|.::..|::.||||.||:::||:::.|:
  Fly     1 MALSVPKAPGVSQMLKDGARMYSGLEEAVFRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFV 65

pombe    65 TNDAATIIRELEVIHPAAKLVVDATQQQENELGDAANFVVVFTGELLAKAENMIRMGLTPLEIAK 129
            |:||.||:|||:|.||||||:|.|:|.|:.|:||..|||||..|.||..||.::|:|:|..||:.
  Fly    66 TSDAGTIMRELDVEHPAAKLIVMASQMQDAEVGDGTNFVVVLAGALLESAEELLRLGITTAEISD 130

pombe   130 GYEMALSHTMEVLEEICADKIETVESEKELIKAIRTCISSKQYGNEDFLSDLVAKAILTVLPKDP 194
            |||.||...:|:|..:.:.|||...:.:::.:.:||.|.|||||.||||:|||:||.:::|| |.
  Fly   131 GYEKALEKALEILPNLVSHKIEDYRNVEKVKEVLRTSIMSKQYGQEDFLNDLVSKACVSILP-DE 194

pombe   195 SKFNVDNIRVVKIMGSSLYNSQVVKGMVFPREPEGTVTRSKEAKVAVFSCPLDISQTETKGTVLL 259
            ..|||||||:.||:||.|..|:||:||||.|..||.||.:::||:.:||||:||.|||||||||:
  Fly   195 GTFNVDNIRICKILGSGLTKSEVVRGMVFKRFVEGDVTYAEKAKIVIFSCPVDIIQTETKGTVLI 259

pombe   260 HNAQEMLDFSKGEENLIESHIKEIYDAGVRVVVTSGNVNDLVLHYLNRFEILVIRVPSKFELRRL 324
            .:|.|:|.||.|||:|:||.||.|.||||:|||..|.|.|:.||:||::.::.:|:.|||:||||
  Fly   260 KSADELLSFSSGEESLLESQIKAIADAGVKVVVAGGKVGDMALHFLNKYGLMAVRLNSKFDLRRL 324

pombe   325 CRVVGATPLARMGVPMPEEMGSVDVVETIEIGGDRVTVFRQVEDITRTATIVLRGATKTYLDDLE 389
            .|.|.||.|.|:..|..||:|..|.|...|:|...:..||.....:|.||:|:||||..::||:|
  Fly   325 SRSVNATVLPRITTPSQEELGYCDKVCIEELGDTTIVAFRNEGKDSRIATVVIRGATDNFMDDIE 389

pombe   390 RAIDDGVNIVKALVKDNRLIFGAGASDMQLCIRLISVGEKTPGIYQHAIKQYGEAFEVVPRTISE 454
            ||:||.:|..|.|.:|.|.:.||||::::|..:|.:..:..||:.|:|::::..|.||.|:.::|
  Fly   390 RALDDAINNFKCLTRDGRYLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANALEVFPKALAE 454

pombe   455 NAGLDPTDVISKLYAAHHKENGESIGVDVECENDGTLDAKEAGIFDVLLAKKSAIRLATETVLTV 519
            |:|::.|:::::||.||:.|.|::||.|:|.|...|:|..:|.:||:..:|...::.|.....|:
  Fly   455 NSGINGTEIVNQLYLAHNNEAGKTIGFDIEAEKASTIDTTKAKLFDLYQSKFWGLKYAVGAAATI 519

pombe   520 LNVDQVVMSKPAGGPK 535
            |.|||::|:|.|||||
  Fly   520 LKVDQIIMAKRAGGPK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cct8	NP_595406.1	chap_CCT_theta	9..528	CDD:274087	243/519 (47%)
cct8	NP_595406.1	Cpn60_TCP1	38..527	CDD:278544	231/488 (47%)
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	241/509 (47%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	232/489 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	475	1.000	Domainoid score	I63
eggNOG	1	0.900	-	-		E1_KOG0362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4802
Inparanoid	1	1.050	523	1.000	Inparanoid score	I219
OMA	1	1.010	-	-		QHG53640
OrthoFinder	1	1.000	-	-		FOG0004632
OrthoInspector	1	1.000	-	-		oto101476
orthoMCL	1	0.900	-	-		OOG6_102087
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1490
SonicParanoid	1	1.000	-	-		X3246
TreeFam	1	0.960	-	-
	14	13.860