DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk25 and par-1

DIOPT Version :9

Sequence 1:	NP_596657.1	Gene:	ppk25 / 2540267	PomBaseID:	SPBC32C12.03c	Length:	423	Species:	Schizosaccharomyces pombe
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	290	Identity:	110/290 - (37%)
Similarity:	168/290 - (57%)	Gaps:	11/290 - (3%)

- Green bases have known domain annotations that are detailed below.

pombe    17 SIPKRSQNIKINQSTKHQRSISDFVGTAGPGRQVGNWIIKKTIGAGSMGKVKLVVNILTGEKAAL 81
            |..|.|.|:::..|...:...::        ..:|.:.:.||||.|:..||||..::.||::.|:
  Fly   225 SSAKGSPNMQMRSSAPMRWRATE--------EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAI 281

pombe    82 KMIPFTPNNTSQTVRVQREALLGRLLRHPNICRVIDCIRTPACTYILFEYVPGGQLLEYILARGK 146
            |:|..|..|.....::.||..:.::|.||||.::...|.|....|::.||..||::.:|::..|:
  Fly   282 KIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGR 346

pombe   147 LDEDLARSFAMQLINALVYLHKNFIVHRDLKIENVLLTQDSR-QVKLIDFGLSNFYSKDDLLRTY 210
            :.|..||....|:::|:.|.|:..|:|||||.||:||  ||. .:|:.|||.||.::....|.|:
  Fly   347 MKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLL--DSELNIKIADFGFSNEFTPGSKLDTF 409

pombe   211 CGSLYFAAPELLDAKPYIGPEVDVWSLGVVIYVMVCGRVPFDDVSVPMLHSKIKSGKLEFPSYIS 275
            |||..:|||||...|.|.|||||||||||::|.:|.|.:|||..::..|..::..||...|.|:|
  Fly   410 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMS 474

pombe   276 EDCCSLIAAMLNVNPRKRCSLEQAAKFPWL 305
            .||.:|:...|.:||.||.|||......|:
  Fly   475 TDCENLLRKFLVLNPAKRASLETIMGDKWM 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk25	NP_596657.1	STKc_Kin1_2	51..305	CDD:270979	104/254 (41%)
ppk25	NP_596657.1	S_TKc	53..305	CDD:214567	103/252 (41%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	103/253 (41%)
		S_TKc	253..504	CDD:214567	103/252 (41%)
		UBA_MARK_Par1	525..563	CDD:270522
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030