Protein Alignment Camk2a and CASK

DIOPT Version :10

• Sequence 1: XP_038952520.1
• Gene: Camk2a / 25400
• RGDID: 2261
• Length: 489
• Species: Rattus norvegicus
• Sequence 2: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Alignment Length: 307
• Identity: 131/307 - (42%)
• Similarity: 189/307 - (61%)
• Gaps: 17/307 - (5%)

  Rat     9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK------LSARDHQKLEREARICRLL 67
            |.:.|:|.|.:|||.||:||||:...:.|::|.||::..|      ||..|   |:|||.||.:|
  Fly     8 FDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTAD---LKREATICHML 69

  Rat    68 KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVARE----YYSEADASHCIQQILEAVLHCHQ 128
            |||:||.|.::.|.||..|::|:.:.|.:|..::|.|.    .||||.|.|.::|||||:.:||:
  Fly    70 KHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHE 134

  Rat   129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQA--WFGFAGTPGYLSPEVLRKDPYG 191
            ..::|||::|...|||:....|.|||..||.||::.|.::.  ..|..|.|.|::|||:.:..||
  Fly   135 NDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199

  Rat   192 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 256
            |..|:|..||:|::||.|..||..... ||.|.:..|...|.:|||.:::..||||:.|||..||
  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANP 263

  Rat   257 SKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAI 303
            ..|::..|.|.||||..|..:.. .|..:||:.||::|||||||||:
  Fly   264 HHRLSITEVLDHPWIRDRDKLQR-THLADTVEELKRYNARRKLKGAV 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Camk2a	XP_038952520.1	STKc_CaMKII	11..302	CDD:270988	128/302 (42%)
		CaMKII_AD	357..484	CDD:285524
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	129/304 (42%)
		L27	347..396	CDD:460717
		L27	406..462	CDD:460717
		PDZ_CASK-like	494..574	CDD:467267
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:395500