|
Human 1 MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFENFVTI 65
||:||.|.||||||.|:.|:|||:.:||:|||::::|.|..:.|..|:.::||:|::.::.|:..
Fly 1 MFTKKSHADVKKSTAKLQDSKKDSASRLRHLRMILDNVELEESKCLFETNYSHVYFILYDTFIQA 65
Human 66 EASLKQKG------HKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGNSLKI 124
||:||||. ||:.|||||..|::.||||.||||.:.:|||.||:..|:.||||.|||.|:
Fly 66 EANLKQKELPFHIVHKAHREELDGSLWLLEKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPKL 130
Human 125 RREGVRLFLLWLQALQNNCSKEQLWMFSCLIPGFSAPQ-SEHGPRT----LDNLINPPL------ 178
||||||.||||.|.|..|.......|::.||||...|| ...||.| .|.|.:|.:
Fly 131 RREGVRYFLLWYQTLGENAPGYVHAMYADLIPGLIVPQKGVVGPDTEFSASDFLTHPNMKADGGM 195
Human 179 ------NLQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQE--R 235
|.....|...|:..|:||.|.:|.........||.||..:|.....|.|::...|: |
Fly 196 ASVFHDNAFSHPVQSSEVVALLPPSSSEKSAPPDPRDGLEVLLNSMVHTAACLRWRDNRAQKDHR 260
Human 236 GFSFLFSHFKKYYLPYIFPNICKENSLYHPILDIPQMRPKPHYVVIKKDAETNEAIYCTKEPFIK 300
.|:||...|...:||...||.....|:|:|.||:|.||. :.||: |....
Fly 261 AFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMRS-----INKKE-----------EVMAS 309
Human 301 ARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQRAAASLVSREESKNDNADKTDRTTEPEQ 365
..|::|.|:..| |.|...
Fly 310 CVVVLINWVSRF-----------------------------------------------THERLL 327
Human 366 SHSNTSTLTEREPSSSSLCSIDEEHLTDIE-----------IVRRVFSSKRSNVNFVTEIFRQAF 419
||....|| |:.|:: |||.|....|.|:|||.|::||||
Fly 328 SHRLDCTL----------------HIEDVDQVRLHGYQQGLIVRDVLYVNRENINFVHEVYRQAF 376
Human 420 LLPIC---EAAAMRKVVKVYQEWIQQEEKPLFMQEPEEIVITSSDLPCIENVTDHDISMEEGEKR 481
||... :..|:|..:.||::|:..|..|.|:.||.: |.|...|.
Fly 377 LLNFTSKPQIEAIRTAIAVYRDWMTGETPPPFLLEPND------DPPPPSNA------------- 422
Human 482 EEENGTNTADHVRNSSWAKNGSYQGALHNASEEATEQNIRAGTQAVLQVFIINSSNIFLLEPANE 546
.||..:..:|.. ||.||:..:.::.. :|||.|.|||||:.|::|:||:..||
Fly 423 ---GGTPRSQRLRTP------SYVGAIAGSKDQLV---VRAGRQNVLQVFVTNAANVFLVNTAN- 474
Human 547 IKNL-------------LDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTESVLKMPS 598
.|: |:|.|::||::||:||.||:...||.:||||:|:|||:||..||.. :
Fly 475 -LNICFPTRSRSYRSTPLEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQ-N 537
Human 599 QAFLQFQGKKNMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSLTYWEELATEWS 663
|..|.....|:.||.|.|...:||||||.||:|:..|.::..||:..|:||.|||:.|||..||:
Fly 538 QHTLPSGTNKSATLGGILGSAIFQTLIVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWN 602
Human 664 LTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQKVSVDKSFSRGWSRDQPGQA 728
.|::|||:|.:|..|.::|.|||||:::|.:.:|.:..| || |
Fly 603 KTIQTLTRVFSRYTYGINLLDLPLDRVAESRAEKRRRIG--------SV-------W-------- 644
Human 729 PMRQRSATTTGSPGTEKARSIVRQKTVAMRSR-SIGECALPSAYIRSAKSAPVLIHTSKPFLPDI 792
|.|.:.:.:.|...|.:.:.|. |.| |:.|.:
Fly 645 ---QGSGSNSAANGGSAASAAISQN----RQRESLAESS-------------------------- 676
Human 793 VLTPLSDELSDIDDAQILPRSTRVRHFSQSEETGNEVFGALNEEQPLPRSSSTSDILEPFTVERA 857
.|:||||.::| |||
Fly 677 --------------------------SSRSEETSSQV--------PLP----------------- 690
Human 858 KGAVPVIDSSSRHAPSLQSSTEASSITRSTESHITDTHSRESSLEVGDSIYDHLCHLIGPVELAD 922
Fly 691 ----------------------------------------------------------------- 690
Human 923 SAFEQIQYIDLEGDDDLLSTLKEYFKENQENHSKNETGKDPASQEVTIAVNRGERLSLDKLECTD 987
||.:.. .
Fly 691 ------------------------------NHPRPH----------------------------H 697
Human 988 QETESENITSFVGTPENLQFQKEPNSAVFMSNIAPNQSDSFFRTQTSEKSKQLNTDKQPSEPSLD 1052
|.|:|:..|.
Fly 698 QHTQSQGGTG------------------------------------------------------- 707
Human 1053 SPCDKEKRKHLYRQAATELDACVDVTLVEKLKSVQINEKITVPHVMRAKKATLKAPVNRRMPHVT 1117
|.|
Fly 708 --------------------------------------------------------------HGT 710
Human 1118 STSKLSPTKRSLSETVTHRAKIMKIATKKRNSVHVTFRPSTESVQFYNPLENKEAPWKMRLRKLG 1182
....|:| .||.:
Fly 711 RPIPLTP---MLSRS-------------------------------------------------- 722
Human 1183 GFSSGSSNSSTSNTHTSTNSATELVKPGVYRPLDTLGTASVSSKTVKESTEIPTTILQKEGIASS 1247
:|.|| :||:
Fly 723 -YSEGS-------------------------------------------------------LASA 731
Human 1248 QLGSRSTLRSSSHEAGLQQGSLGGVYKTVVHALSKPKANVSPQR--QNRMPPEAPLRDLYSHVMG 1310
...||...|.: |..|||| :.|.: :||:.|:
Fly 732 ARSSRIRRRRA--------------------ATPKPKA-LQPSQLAENRINPQ------------ 763
Human 1311 YFGRKAAVNKEDMSQKLPPLNSDIGGSSANVPDLMDEFIAERLRSGNASTMTRRGSSPGSLEIPK 1375
|| ||..|..||
Fly 764 --------------------------------DL------------------RRAMSLDSL---- 774
Human 1376 DLPDILNKQNQMRPIDDPGVPSEWTSPASAGSSDLISSDSHSDSFSAFQYDGRKFDNFGFGTDTG 1440
|...|...:||:.:
Fly 775 -----------------------------ARKGDAEETDSYQE---------------------- 788
Human 1441 VTSSADVDSGSGHHQSAEEQEVASLTTLHIDSETSSLNQQAFSAEVATITGSESASPVHSPLGSR 1505
.|.:||: |||
Fly 789 ----GDNESGA---------------------------------------------------GSR 798
Human 1506 SQTPSPSTLNIDHMEQKD--LQLDEKLHHSVLQTPDDLEISEFPSECCS--------VMAGGTLT 1560
|.:|:.|: .|:....|| ||:|..| ||.....:.|...| ::.||:..
Fly 799 SPSPTASS-GIEGGSIKDAQLQIDASL--------DDANSGSYGSGSNSGSISGRRCIILGGSAE 854
Human 1561 GWHADVATVMWRRMLGILGDVNSIMDPEIHAQVFDYLCELWQNLAKIRDNLGISTDNL-TSPSPP 1624
|||.|..::||:||||.|||||.|...::|||||.:|.|:.|||.||:.|.||||||. |.|.||
Fly 855 GWHPDSTSIMWKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGISTDNQNTQPMPP 919
Human 1625 VLIPPLRILTPWLFKATMLTDKYKQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHI 1689
|:||:.|:.||.:.:..|...:|:|||.|.:|:|:...:. :.|...|..||:.:|..|...
Fly 920 -LVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLAIQG---AVNMQQLPLFYHALHQLLTGE 980
Human 1690 DQDIVNTIIKHC-SPQFFSLGLPGATMLIMDFIVAAGRVASSAFL--NAPRVEAQVLLGSLVCFP 1751
|:|::..|:||. .|:..||.|||.|:|::|.:.|:..:.:|..: :.||.|...|||||:|:|
Fly 981 DRDLIYAILKHLEGPRLLSLLLPGHTLLLLDLVHASAILLTSLEVSRSTPRAEVAALLGSLLCYP 1045
Human 1752 NLYCELPSLHPNIPDVAVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEEL----- 1811
:.......|.|......:.:.:|:::.|:..||..||.|||..|||:||..||.|:...|
Fly 1046 SSLLTRSVLQPTPQKFELMECSDLQDHILNIVLRCARREPSAKARCIALSQLGQWLLMRLSQPLP 1110
Human 1812 -------------------VHES----HHPQIKEALNVICVSLKFTNKTVAHVACNMLHMLVHYV 1853
||.. ::|:|||.|.|:..:|:|.:.|:|.||.:.|.:.....
Fly 1111 ASNSGRANLFQQAVPHHKDVHPKASSVYNPRIKEVLQVLLQALQFKHHTIAIVAVDSLKLCAERG 1175
Human 1854 PRLQIYQPDSPLKIIQILIATITHLLP-STEASSYEMDKRLVVSLLLCLLDWIMALPLKTLLQPF 1917
.:|...: ::.|::|..|...|. .:.....:.||.::.||:|||.::.||:|...:|.||
Fly 1176 RQLAAIE-----RVPQLIITAICKALEIQSVTKPKDSDKVVLTSLMLCLGEFCMAIPAPIMLTPF 1235
Human 1918 HATGAESDKTEKSVLNCIYKVLHGCVYGAQCFSNPRYFPMSLSDLASVDYDPFMHL--ESLKEPE 1980
:..| |.....||..:.:|..|. ||:..:.|: |..|:| ||: :.|:...
Fly 1236 NEQG---DTLVLQVLRVLLQVASGA---------PRHERVKLT--ADDDFD--MHIAHDDLQGDG 1284
Human 1981 PLHSPDSERSSKLQP-VTEVKTQMQHGLISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHD 2044
.|.....:.|..:|. :|.:| :.|:.|..|||.|:||:||..|.:.|:|.|.|..|
Fly 1285 RLPEATYQTSETIQKCITAIK---------LCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDD 1340
Human 2045 ----------NHYSESTELSPELFESPNIQFFVLNNTTLVSCIQIRSEENMPGGGLSAGLASANS 2099
....:|.|| |.:..:.|:|.|:||:..:.|.|::.:.: :||||::|||.:|:.
Fly 1341 IGNAAYGGQVETRRDSVEL-PSVVSAQNMQLFMLNSGLVASFIELPTLK-LPGGGITAGLVTADK 1403
Human 2100 NVRIIVRDLSGKYSWDSAILYGPPPVSGLSEPTSFMLSLSHQEKPEEPPTSNECLEDITVKDGLS 2164
.||:::|||:||..||::||| ||| ...||||.:...::.....|.::
Fly 1404 QVRVLMRDLNGKACWDASILY--------SEP----------RNAEEPPKTTPKIQHSQPLDSMA 1450
Human 2165 LQF------------KRFRETVPTWDTIRDEEDVLDELLQYLGVTSPECLQRTGISLNIPAPQPV 2217
... .|....:|....:..:.|.||::|.|:|.|||||:..|...||.|...|
Fly 1451 TSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASP- 1514
Human 2218 CISEKQENDVINAILKQHTEEKEFVE----------KHFNDLNMKAVEQD-----------EPIP 2261
:|..||...|:.||.|...|:|||. :|.:. |....:.| :.:|
Fly 1515 -LSGNQEAQAISVILNQRLLEQEFVTHSTQAPSPALRHASS-NSSLQQPDQRSLHSTTASFDSLP 1577
Human 2262 QKPQSAFYYCRLLLSILGMNSWDKRRSFHLLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQE 2326
.:.:..|.|||||.|.||:..|::|...|||:::|||:|||||:|.::||||||:||.|||.|||
Fly 1578 TRTEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQE 1642
Human 2327 DKHSILTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQKNKSTGLTTPYFATSTVEVIFHVSTR 2391
||.|||.||.||..||.||:.||||::|..|.||:|||.: :..|.|.||:||..:||::||:||
Fly 1643 DKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPR-QGCGATAPYYATPFLEVVYHVATR 1706
Human 2392 MPSDSDDSLTKKLRHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPE 2456
|||||.:::..|.|||||||||||||||.|||||.|:||||.|||||:||::|.:|.:.:.:|||
Fly 1707 MPSDSSEAMLLKTRHLGNDEVHIVWSEHNRDYRRDILPTEFCDVLIVVYPLRNGLFRVTVNRKPE 1771
Human 2457 VPFFGPLFDGAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2521
||:||||.:.::|:|..|..::|||||||||..::.:||||.|||||.|.|.::...:.|.||||
Fly 1772 VPWFGPLANESVVSGACLATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFE 1836
Human 2522 DFAAQVFSPAPYHHL----PSDA--------------------------------VGSYPEILPS 2550
|||:::::|.|...| .|:| :|..|.....
Fly 1837 DFASRIYNPMPLSTLGTLRESNASSSAAPLASALLDHNRASVKGWVQASIDSGPIMGIAPSASAG 1901
Human 2551 ETPTATQVDGADLASPMSPR 2570
.|.......|...|||..||
Fly 1902 STAAMEAATGMSSASPRGPR 1921
| 
