DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arrb2 and Arr1

DIOPT Version :9

Sequence 1:	NP_037043.1	Gene:	Arrb2 / 25388	RGDID:	2157	Length:	410	Species:	Rattus norvegicus
Sequence 2:	NP_001246073.1	Gene:	Arr1 / 35078	FlyBaseID:	FBgn0000120	Length:	364	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	151/347 - (43%)
Similarity:	233/347 - (67%)	Gaps:	6/347 - (1%)

- Green bases have known domain annotations that are detailed below.

  Rat     8 RVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLK-DRKVFVTLTCAFRYGREDLDV 71
            :||||.|||..:|:|:.:|||||.:.:|:|:||::::|.:|:: :||:||.|.|.|||||||.::
  Fly     6 KVFKKCSPNNMITLYMNRRDFVDSVTQVEPIDGIIVLDDEYVRQNRKIFVQLVCNFRYGREDDEM 70

  Rat    72 LGLSFRKDLFIATYQAFPPMPNPPRPPTRLQDRLLKKLGQHAHPFFFTIPQNLPCSVTLQPGPED 136
            :||.|:|:|.:.:.|..||.....: .|::|:|||||||.:|:||...:|.:.|.||.||....|
  Fly    71 IGLRFQKELTLVSQQVCPPQKQDIQ-LTKMQERLLKKLGSNAYPFVMQMPPSSPASVVLQQKASD 134

  Rat   137 TGKACGVDFEIRAFCAKSIEEKSHKRNSVRLIIRKVQFAPETPGPQPSAETTRHFLMSDRRSLHL 201
            ..:.|||.:.::.|...|..::||:|:::.|.|||||:||...|.||.....:.||:|. ..|.|
  Fly   135 ESQPCGVQYFVKIFTGDSDCDRSHRRSTINLGIRKVQYAPTKQGIQPCTVVRKDFLLSP-GELEL 198

  Rat   202 EASLDKELYYHGEPLNVNVHVTNNSAKTVKKIRVSVRQYADICLFSTAQYKCPVAQLEQDD--QV 264
            |.:|||:||:|||.::||:.|.|||.|.||||:..|:|..|:.||...|::..:|.:|..:  .:
  Fly   199 EVTLDKQLYHHGEKISVNICVRNNSNKVVKKIKAMVQQGVDVVLFQNGQFRNTIAFMETSEGCPL 263

  Rat   265 SPSSTFCKVYTITPLLSDNREKRGLALDGQLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKL 329
            :|.|:..||..:.|.|..|.::.|:|::|.:|.:||.|||:|::.....::..||:|||.|||||
  Fly   264 NPGSSLQKVMYLVPTLVANCDRAGIAVEGDIKRKDTALASTTLIASQDARDAFGIIVSYAVKVKL 328

  Rat   330 VV-SRGGDVSVELPFVLMHPKP 350
            .: :.||::..||||:||||||
  Fly   329 FLGALGGELCAELPFILMHPKP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arrb2	NP_037043.1	Arrestin_N	19..175	CDD:278754	67/156 (43%)
		Arrestin_C	199..350	CDD:214976	67/153 (44%)
		Interaction with TRAF6. /evidence=ECO:0000250	241..410		45/113 (40%)
		Interaction with AP2B1	378..410
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250	386..396
Arr1	NP_001246073.1	Arrestin_N	17..173	CDD:304627	67/156 (43%)
Arr1	NP_001246073.1	Arrestin_C	192..350	CDD:214976	68/158 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52566
OrthoDB	1	1.010	-	-		D340461at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11792
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930