Protein Alignment ZDHHC20 and app

DIOPT Version :10

• Sequence 1: NP_001316988.1
• Gene: ZDHHC20 / 253832
• HGNCID: 20749
• Length: 365
• Species: Homo sapiens
• Sequence 2: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Alignment Length: 297
• Identity: 80/297 - (26%)
• Similarity: 124/297 - (41%)
• Gaps: 55/297 - (18%)

Human     1 MAP-------WTLWR-----CCQRVVGWVP---VLFITFVVVWS----YYAYVVELCVFTIFGNE 46
            |||       |.|:.     .|..::...|   |.::|.:::..    ::|:.   |.|..   :
  Fly    12 MAPNQRVTRKWELFAGRNKFYCDGLLMSAPHTGVFYLTCILITGTSALFFAFD---CPFLA---D 70

Human    47 ENGKTVVYLVAFHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEK--EFSQERQQEILRR 109
            .....:..:.|...||.|.  |...|.||.|....:   .||.|....||  |..........|.
  Fly    71 SINPAIPIVGAVLYFFTMS--SLLRTTFTDPGVIPR---ASNDEAAYIEKQIEVPNSLNSPTYRP 130

Human   110 AARALPIYTTSASKTIRYCEKCQLIKPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLF 174
            ..|...:.....:..::||..|::.:|.||.|||.||:|:.:.|||||||.||||..||:||.||
  Fly   131 PPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLF 195

Human   175 LLYSLLYCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFI-----------SVLSLF 228
            |:......:|:.:..:.:.:.....|        |.:|....:|.|.:           ||:.|.
  Fly   196 LVSLAFLAVFIFSCSVTHLVLLMKKE--------HEVFNVIKAAPFTVIVVFICFFSIWSVIGLA 252

Human   229 SYHCWLVGKNRTTIESFRAPTFSY--GP-DGNGFSLG 262
            .:|.:|...::||.|..:. :||.  || ..|.:|.|
  Fly   253 GFHTYLTTSDQTTNEDLKG-SFSSKGGPRTQNPYSRG 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC20	NP_001316988.1	DHHC	16..301	CDD:418707	74/270 (27%)
app	NP_648561.2	DHHC	146..270	CDD:396215	44/131 (34%)