DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZDHHC20 and app

DIOPT Version :9

Sequence 1:NP_001316988.1 Gene:ZDHHC20 / 253832 HGNCID:20749 Length:365 Species:Homo sapiens
Sequence 2:NP_648561.2 Gene:app / 39399 FlyBaseID:FBgn0260941 Length:755 Species:Drosophila melanogaster


Alignment Length:297 Identity:80/297 - (26%)
Similarity:124/297 - (41%) Gaps:55/297 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAP-------WTLWR-----CCQRVVGWVP---VLFITFVVVWS----YYAYVVELCVFTIFGNE 46
            |||       |.|:.     .|..::...|   |.::|.:::..    ::|:.   |.|..   :
  Fly    12 MAPNQRVTRKWELFAGRNKFYCDGLLMSAPHTGVFYLTCILITGTSALFFAFD---CPFLA---D 70

Human    47 ENGKTVVYLVAFHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEK--EFSQERQQEILRR 109
            .....:..:.|...||.|.  |...|.||.|....:   .||.|....||  |..........|.
  Fly    71 SINPAIPIVGAVLYFFTMS--SLLRTTFTDPGVIPR---ASNDEAAYIEKQIEVPNSLNSPTYRP 130

Human   110 AARALPIYTTSASKTIRYCEKCQLIKPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLF 174
            ..|...:.....:..::||..|::.:|.||.|||.||:|:.:.|||||||.||||..||:||.||
  Fly   131 PPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLF 195

Human   175 LLYSLLYCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFI-----------SVLSLF 228
            |:......:|:.:..:.:.:.....|        |.:|....:|.|.:           ||:.|.
  Fly   196 LVSLAFLAVFIFSCSVTHLVLLMKKE--------HEVFNVIKAAPFTVIVVFICFFSIWSVIGLA 252

Human   229 SYHCWLVGKNRTTIESFRAPTFSY--GP-DGNGFSLG 262
            .:|.:|...::||.|..:. :||.  || ..|.:|.|
  Fly   253 GFHTYLTTSDQTTNEDLKG-SFSSKGGPRTQNPYSRG 288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZDHHC20NP_001316988.1 zf-DHHC 16..301 CDD:327686 74/270 (27%)
Substrate binding. /evidence=ECO:0000305|PubMed:29326245 140..143 1/2 (50%)
appNP_648561.2 zf-DHHC 146..270 CDD:279823 44/131 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5273
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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